Noscapine shows antimalarial activity against Plasmodium falciparum 3D7, its clinical isolate Pf140/SS, and Plasmodium berghei ANKA
Objective: To evaluate the antimalarial activity of noscapine against Plasmodium falciparum 3D7 strain (Pf3D7), its clinical isolate (Pf140/SS), and Plasmodium berghei ANKA (PbA). Methods: Using ring-stage survival assay, phenotypic assessments, and SYBR-green-based fluorescence assay, the antimalar...
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| Published in: | Asian Pacific journal of tropical biomedicine Vol. 14; no. 8; pp. 350 - 358 |
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| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
01-08-2024
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| Abstract | Objective: To evaluate the antimalarial activity of noscapine against Plasmodium falciparum 3D7 strain (Pf3D7), its clinical isolate (Pf140/SS), and Plasmodium berghei ANKA (PbA). Methods: Using ring-stage survival assay, phenotypic assessments, and SYBR-green-based fluorescence assay, the antimalarial activities of noscapine were assessed compared with dihydroartemisinin (DHA) in in vivo and in vitro studies. In addition, hemolysis and cytotoxicity tests were carried out to evaluate its safety. RT-PCR assay was also conducted to determine the effect of noscapine on papain-like cysteine protease Plasmodium falciparum falcipain-2 (PfFP-2). Results: The antimalarial efficacy of noscapine against Pf3D7 and Pf140/SS was comparable to DHA, with IC50 values of (7.68±0.88) and (5.57±0.74) nM/mL, respectively, and >95% inhibition of PbA infected rats. Noscapine also showed a safe profile, as evidenced by low hemolysis and cytotoxicity even at high concentrations. Moreover, PfFP-2 expression was significantly inhibited in both noscapine-treated Pf3D7 and Pf140/SS (P<0.01). Conclusions: Noscapine has antimalarial properties comparable to standard antimalarial DHA with better safety profiles, which may be further explored as a therapeutic candidate for the treatment of malaria. |
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| AbstractList | Objective: To evaluate the antimalarial activity of noscapine against Plasmodium falciparum 3D7 strain (Pf3D7), its clinical isolate (Pf140/SS), and Plasmodium berghei ANKA (PbA). Methods: Using ring-stage survival assay, phenotypic assessments, and SYBR-green-based fluorescence assay, the antimalarial activities of noscapine were assessed compared with dihydroartemisinin (DHA) in in vivo and in vitro studies. In addition, hemolysis and cytotoxicity tests were carried out to evaluate its safety. RT-PCR assay was also conducted to determine the effect of noscapine on papain-like cysteine protease Plasmodium falciparum falcipain-2 (PfFP-2). Results: The antimalarial efficacy of noscapine against Pf3D7 and Pf140/SS was comparable to DHA, with IC50 values of (7.68±0.88) and (5.57±0.74) nM/mL, respectively, and >95% inhibition of PbA infected rats. Noscapine also showed a safe profile, as evidenced by low hemolysis and cytotoxicity even at high concentrations. Moreover, PfFP-2 expression was significantly inhibited in both noscapine-treated Pf3D7 and Pf140/SS (P<0.01). Conclusions: Noscapine has antimalarial properties comparable to standard antimalarial DHA with better safety profiles, which may be further explored as a therapeutic candidate for the treatment of malaria. |
| Author | Chhatria, Satyaranjan Behera, Prativa K. Kanhar, Satish Sahu, Praveen Kishore Nanda, Ashirbad Naik, Pradeep Kumar Babu, Swaraj Kumar Sahoo, Dibya Ranjan Maharana, Sameer Mohanty, Sanjib |
| Author_xml | – sequence: 1 givenname: Swaraj Kumar surname: Babu fullname: Babu, Swaraj Kumar organization: Centre of Excellence in Natural Products and Therapeutics, Department of Biotechnology and Bioinformatics, Sambalpur University, Jyoti Vihar, Sambalpur Odisha, India, Department of Molecular Biology and Infectious Diseases, Community Welfare Society Hospital, Rourkela, Odisha, India, Molecular & Immunology Laboratory, Infectious Disease Biology Unit, Ispat General Hospital, Rourkela, Odisha, India – sequence: 2 givenname: Sameer surname: Maharana fullname: Maharana, Sameer organization: Molecular & Immunology Laboratory, Infectious Disease Biology Unit, Ispat General Hospital, Rourkela, Odisha, India – sequence: 3 givenname: Satyaranjan surname: Chhatria fullname: Chhatria, Satyaranjan organization: Department of Molecular Biology and Infectious Diseases, Community Welfare Society Hospital, Rourkela, Odisha, India – sequence: 4 givenname: Dibya Ranjan surname: Sahoo fullname: Sahoo, Dibya Ranjan organization: Centre of Excellence in Natural Products and Therapeutics, Department of Biotechnology and Bioinformatics, Sambalpur University, Jyoti Vihar, Sambalpur Odisha, India – sequence: 5 givenname: Ashirbad surname: Nanda fullname: Nanda, Ashirbad organization: Department of Pharmacy, Centurion University of Technology and Management, Bhubaneswar, Odisha, India – sequence: 6 givenname: Satish surname: Kanhar fullname: Kanhar, Satish organization: Department of Pharmacy, Centurion University of Technology and Management, Bhubaneswar, Odisha, India – sequence: 7 givenname: Prativa K. surname: Behera fullname: Behera, Prativa K. organization: Molecular & Immunology Laboratory, Infectious Disease Biology Unit, Ispat General Hospital, Rourkela, Odisha, India – sequence: 8 givenname: Sanjib surname: Mohanty fullname: Mohanty, Sanjib organization: Department of Molecular Biology and Infectious Diseases, Community Welfare Society Hospital, Rourkela, Odisha, India, Molecular & Immunology Laboratory, Infectious Disease Biology Unit, Ispat General Hospital, Rourkela, Odisha, India – sequence: 9 givenname: Pradeep Kumar surname: Naik fullname: Naik, Pradeep Kumar organization: Centre of Excellence in Natural Products and Therapeutics, Department of Biotechnology and Bioinformatics, Sambalpur University, Jyoti Vihar, Sambalpur Odisha, India – sequence: 10 givenname: Praveen Kishore surname: Sahu fullname: Sahu, Praveen Kishore organization: Centre of Excellence in Natural Products and Therapeutics, Department of Biotechnology and Bioinformatics, Sambalpur University, Jyoti Vihar, Sambalpur Odisha, India, Department of Molecular Biology and Infectious Diseases, Community Welfare Society Hospital, Rourkela, Odisha, India, Molecular & Immunology Laboratory, Infectious Disease Biology Unit, Ispat General Hospital, Rourkela, Odisha, India |
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| SubjectTerms | antimalarial cytotoxicity dihydroartemisinin falcipain-2 malaria noscapine plasmodium berghei plasmodium falciparum |
| Title | Noscapine shows antimalarial activity against Plasmodium falciparum 3D7, its clinical isolate Pf140/SS, and Plasmodium berghei ANKA |
| URI | https://doaj.org/article/0a6f21f5bb4d4356b5362a2383390550 |
| Volume | 14 |
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