Evaluation of the Effects of Propolis and Xylitol Chewable Tablets on the Salivary Concentrations of Oral Micro-organisms in Orthodontic Patients: A Pilot Study

• Published in: Journal of young pharmacists Vol. 13; no. 1; pp. 68 - 71
• Main Authors: Siqueira, Erica Cardoso, Teofilo Campos, Fernanda Maria, Mendes, Jerlyson Coelho, Lima, Larisse Nogueira De, Araujo, Ruth Sousa, Sousa Gomes, Nara Karoliny, Silva Lima, Luiza Rayanne da, Nogueira, Rodrigo Freires, Silva Rocha, Maria Celia da, Viana Barros, Raimundo Juarez, Marques Bandeira, Carlos Eduardo, Sales, Jair Paulino de, Siqueira Fraga, Edmir Geraldo de, Nogueira, Lara da Silva, Oliveira Meneses, Carlos Augusto, Albuquerque, Roberto Lima de, Barbosa Calcia, Thayanne Brasil, Dantas Lobo, Patricia Leal, Rodrigues Neto, Edilson Martins
• Format: Journal Article
• Language: English
• Published: Bangalore InPharm 01-01-2021
• Subjects: Antimicrobial agents; Body fluids; Herbal medicine; Microbiota; Mouth; Orthodontics; Streptococcus infections
• DOI: 10.5530/jyp.2021.13.15
• EISSN: 0975-1505
• ISSN: 0975-1483

Objectives: This study sought to evaluate the effectiveness of red propolis and xylitol chewable tablets in reducing concentrations of micro-organisms such as Streptococcus mutans (SM) and gram-negative bacteria (GNB). Methods: A total of 12 volunteers of both sexes presenting no caries (ICDAS II 0), users of fixed orthodontic appliances and with visible plaque index were randomly assigned to one of two groups. Was to determine the variations in the concentrations of SM and GNB in the saliva before and after the administration of the chewable tablets. The appearance of adverse reactions and side effects was analyzed. The Mann-Whitney (parametric) test was used for pairwise comparisons of means. The Wilxocon test was also used. Results: The study revealed that the propolis and xylitol chewable tablets had antimicrobial activity, reducing the concentration of GNB by -1.39 log10 CFU/mL (p = 0.036) and compared to placebo (p = 0.004698). There was a significant reduction of SM of -0.22 log10 CFU/mL (p = 0.031) and compared to placebo (p = 0.002165). Conclusion: Thus, in addition to the good safety profile, with a low rate of adverse effects, red propolis and xylitol tablets proved to be an effective potential low-cost alternative to combat dental caries and other periodontal diseases.