Apolipoprotein C-III, familial chylomicronemia syndrome, and olezarsen
Reducing the synthesis of apoC-III reduces fasting triglycerides in individuals lacking lipoprotein lipase activity. Recently, Stroes et al. published a phase 3 trial on the effects of olezarsen, a third-generation antisense oligonucleotide that blocks apoC-III mRNA, on triglycerides and risk of acu...
Saved in:
| Published in: | Med (New York, N.Y. : Online) Vol. 5; no. 6; p. 493 |
|---|---|
| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
14-06-2024
|
| Subjects: | |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Reducing the synthesis of apoC-III reduces fasting triglycerides in individuals lacking lipoprotein lipase activity. Recently, Stroes et al.
published a phase 3 trial on the effects of olezarsen, a third-generation antisense oligonucleotide that blocks apoC-III mRNA, on triglycerides and risk of acute pancreatitis. |
|---|---|
| AbstractList | Reducing the synthesis of apoC-III reduces fasting triglycerides in individuals lacking lipoprotein lipase activity. Recently, Stroes et al.
published a phase 3 trial on the effects of olezarsen, a third-generation antisense oligonucleotide that blocks apoC-III mRNA, on triglycerides and risk of acute pancreatitis. |
| Author | Valdivielso, Pedro Coca Prieto, Inmaculada |
| Author_xml | – sequence: 1 givenname: Pedro surname: Valdivielso fullname: Valdivielso, Pedro email: valdivielso@uma.es organization: Lipid Unit, Servicio de Medicina Interna, Hospital Universitario Virgen de la Victoria, Departamento de Medicina y Dermatología, Instituto de Investigación Biomédica (IBIMA-Plataforma BIONAND), Universidad de Málaga, Málaga, Spain. Electronic address: valdivielso@uma.es – sequence: 2 givenname: Inmaculada surname: Coca Prieto fullname: Coca Prieto, Inmaculada organization: Lipid Unit, Servicio de Medicina Interna, Hospital Universitario Virgen de la Victoria, Departamento de Medicina y Dermatología, Instituto de Investigación Biomédica (IBIMA-Plataforma BIONAND), Universidad de Málaga, Málaga, Spain |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38878767$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1j0tOwzAARC0EoqX0AiyQD9AE2_F3WUUUIlViA-vKvwhXsR05ZRFOTyRgMZrdvHl34Drl5AF4wKjGCPOncx29O9cEEVojViNEr8CacM4r3lC0AttpOiOECMMNVuQWrBophRRcrMFhP-YhjHks-eJDgm3Vdd0O9jqGIegB2s95yDHYshBj0HCakys5-h3UycE8-G9dJp_uwU2vh8lv_3oDPg7P7-1rdXx76dr9sbKkEZeKSW0dV7QxkijqeoYlUlYoiVWPl9jlk2e95EZjyYhhVAmDDVW94Yw7Tzbg8Xd3_DKL82ksIeoyn_6FyA_8gk6V |
| ContentType | Journal Article |
| Copyright | Copyright © 2024 Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: Copyright © 2024 Elsevier Inc. All rights reserved. |
| DBID | CGR CUY CVF ECM EIF NPM |
| DOI | 10.1016/j.medj.2024.05.004 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
| DatabaseTitleList | MEDLINE |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2666-6340 |
| ExternalDocumentID | 38878767 |
| Genre | Journal Article |
| GroupedDBID | 0R~ 53G AALRI AAMRU AAXUO AKRWK ALMA_UNASSIGNED_HOLDINGS CGR CUY CVF EBS ECM EIF FDB M41 NPM |
| ID | FETCH-LOGICAL-c237t-58acd6943b8294df51809c79819f119fc767e5f86ba1852b5497b1b49fb656de2 |
| IngestDate | Sat Nov 02 12:13:38 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Language | English |
| License | Copyright © 2024 Elsevier Inc. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c237t-58acd6943b8294df51809c79819f119fc767e5f86ba1852b5497b1b49fb656de2 |
| PMID | 38878767 |
| ParticipantIDs | pubmed_primary_38878767 |
| PublicationCentury | 2000 |
| PublicationDate | 2024-06-14 |
| PublicationDateYYYYMMDD | 2024-06-14 |
| PublicationDate_xml | – month: 06 year: 2024 text: 2024-06-14 day: 14 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Med (New York, N.Y. : Online) |
| PublicationTitleAlternate | Med |
| PublicationYear | 2024 |
| SSID | ssj0002513192 |
| Score | 2.3104198 |
| Snippet | Reducing the synthesis of apoC-III reduces fasting triglycerides in individuals lacking lipoprotein lipase activity. Recently, Stroes et al.
published a phase... |
| SourceID | pubmed |
| SourceType | Index Database |
| StartPage | 493 |
| SubjectTerms | Apolipoprotein C-III - blood Apolipoprotein C-III - genetics Benzimidazoles Humans Hyperlipoproteinemia Type I - blood Hyperlipoproteinemia Type I - genetics Oligonucleotides - pharmacology Oligonucleotides - therapeutic use Oligonucleotides, Antisense - pharmacology Oligonucleotides, Antisense - therapeutic use Pancreatitis - genetics Triglycerides - blood |
| Title | Apolipoprotein C-III, familial chylomicronemia syndrome, and olezarsen |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/38878767 |
| Volume | 5 |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3NS8MwFA9OYewifn9LDt5cx5amTXscc2M7TAQneBtJm6DDbgP14l_vS9J0tSrqwcNKSSAteb-9vPf63vshdMHBJJCkIz3BSeJRTuBOU4YxFoRJmyilhA64DW_Z9X101af91RfT1di_ShrGQNa6cvYP0i4WhQG4B5nDFaQO11_JvatpF5YL039BV_R5o9FI76OJZOjwePIAPnqm8_DmMnvkRc8Cl8e5eJJv4O3mJWKO7EmmX_H2mIBCuVtpTt71pKu84NRd2BRgWL_41gFn5-UN-OeGvgnUU8Z1JmweF8jDD4TqNClb9tmSRk3BCR96oW-bLjmdGpSgU9aP1NIhftLbNoQwa4EFMGvpx5h2qpaYuCS0ZWak5oNmBC3Ofp6t9NJ2UzVUA8tIG8-9cRGRA0sP9BHJK6tsEmD1fRqo7tao-CHGHplsoc3ckcBdi4BttCbnO6g-zlMldtHgIxCwAUITOxjgCgywg0ETAwhwAYI9dDfoT3pDLyfN8BLisxcviHiShjH1RURimqpAN2hLWAyWn-rAL4FXl4GKQsF13bwIaMxER9BYCTDtU0n20focnnyIsIJ5KlI_5YJSJVSkuxuythC-Tzgj7SN0YHdgurSdUaZub46_nTlBjRWKTtGGgr-dPEO15_T13IjjHYP6Sf4 |
| link.rule.ids | 782 |
| linkProvider | EBSCOhost |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Apolipoprotein+C-III%2C+familial+chylomicronemia+syndrome%2C+and+olezarsen&rft.jtitle=Med+%28New+York%2C+N.Y.+%3A+Online%29&rft.au=Valdivielso%2C+Pedro&rft.au=Coca+Prieto%2C+Inmaculada&rft.date=2024-06-14&rft.eissn=2666-6340&rft.volume=5&rft.issue=6&rft.spage=493&rft_id=info:doi/10.1016%2Fj.medj.2024.05.004&rft_id=info%3Apmid%2F38878767&rft_id=info%3Apmid%2F38878767&rft.externalDocID=38878767 |