ENPP1 enzyme replacement therapy improves ectopic calcification but does not rescue skeletal phenotype in a mouse model for craniometaphyseal dysplasia

Craniometaphyseal dysplasia (CMD) is a rare genetic bone disorder, characterized by progressive thickening of craniofacial bones and flared metaphyses of long bones. Craniofacial hyperostosis leads to the obstruction of neural foramina and neurological symptoms such as facial palsy, blindness, deafn...

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Bibliographic Details

Published in:	JBMR plus Vol. 8; no. 9; p. ziae103
Main Authors:	Reichenberger, Ernst J, O'Brien, Kevin, Hatori, Ayano, Carpenter, Thomas O, van de Wetering, Koen, Flaman, Lisa, Howe, Jennifer, Ortiz, Daniel, Sabbagh, Yves, Chen, I-Ping
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01-09-2024
Subjects:	genetic animal models bone QCT/μCT osteoblasts osteoclasts
Online Access:	Get full text
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