1, 8-Naphthalimide-based fluorescent sensor with highly selective and sensitive detection of Zn2+ in aqueous solution and living cells

• Published in: Inorganic chemistry communications Vol. 106; pp. 43 - 47
• Main Authors: Liu, Daying, Yin, Xin, Deng, Xinxin, Shi, Jun, Zhu, Hualing, Shang, Zhiqiang, Chen, Jiatong, Yang, Guangming, He, Huarui
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-08-2019
• Subjects: Fluorescent sensor; Iminoethoxyacetic acid; Iminopicolinic acid; Naphthalimide; Zinc; Iminoethoxyacetic acid; Fluorescent sensor; Naphthalimide; Iminopicolinic acid; Zinc
• ISSN: 1387-7003; 1879-0259
• DOI: 10.1016/j.inoche.2019.05.026

A new 4-amino-1, 8-naphthalimide-based fluorescent sensor, with iminoethoxyacetic acid and iminopicolinic acid as receptor, was developed and applied successfully to image Zn2+ in living cells. Under physiological pH conditions, it demonstrates high selectivity and sensitivity for sensing Zn2+ with about 30-fold enhancement in aqueous solution, with a characteristic emission band of 4-amino-1,8-naphthalimide with a green color centered at 550 nm.
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•1, 8-Naphthalimide-based fluorescent Zn2+ sensor with a new receptor contained two different arms was synthesized.•It demonstrates high selectivity and sensitivity for sensing Zn2+ with about 41-fold enhancement.•It was applied successfully to detection of Zn2+ in aqueous solution and image Zn2+ in living cells.