Кlotho protein level in patients with myocardial infarction and chronic obstructive pulmonary disease in relation to the number of stenosis

• Published in: Medicinskij sovet no. 14; pp. 54 - 60
• Main Authors: Voronina, L. P., Kespleri, E. V., Akhmineeva, A. Kh, Polunina, O. S., Kuzmichev, B. Yu, Polunina, E. A.
• Format: Journal Article
• Language: English; Russian
• Published: Remedium Group LLC 18-10-2021
• Subjects: chronic obstructive pulmonary disease; comorbid pathology; coronary angiography; klotho protein; myocardial infarction
• ISSN: 2079-701X; 2658-5790
• DOI: 10.21518/2079-701X-2021-14-54-60

Introduction.
The clinical course and outcome in patients with comorbid pathology has a number of features that require further investigation. The investigation of biomarkers is important in this area as any change in their levels reflects the severity of pathogenetic changes and has prognostic value. Cardiovascular disease (CVD) and chronic obstructive pulmonary disease (COPD) are one of the most frequently reported comorbid pathologies. This is due to a large number of common interrelated links of pathogenesis and risk factors.
The aim of the study.
To study and analyze, in a comparative aspect, the level of Klotho protein in patients with MI and patients with MI and COPD, in relation to the number of stenosis of coronary arteries (CA) according to coronary angiography.
Materials and methods
. 110 patients were examined, divided into two groups: the main group - patients with MI on the background of COPD (n = 60) and the comparison group – patients with MI (n = 50). Somatically healthy individuals (n = 30) were examined as a control group. Determination of Klotho protein level in plasma samples was carried out by enzyme-linked immunosorbent assay
Results
. It was found that in patients with MI and COPD, the level of Klotho protein was statistically significantly lower than in the control group and in patients with MI. The relationship between the Klotho protein level and lipid profile parameters was revealed in both patients with MI and patients with MI and COPD, with a greater strength of relationships in patients with comorbid pathology. It was also found that in the group of patients with comorbid pathology in individuals with lesions of one, two, three or more CA, the Klotho level was statistically significantly lower than in patients with MI with the corresponding number of affected CA.
Conclusions.
The results obtained prove the promise and the need for further study of the pathogenetic role of the Klotho protein level in patients with comorbid pathology.