Rational design of nanocarriers based on gellan gum/retrograded starch exploiting polyelectrolyte complexation and ionic cross-linking processes: A potential technological platform for oral delivery of bevacizumab

The structural fragility of monoclonal antibodies (mAbs), such as bevacizumab (BVZ), is a critical parameter for oral administration and can limit the use of several technologies to produce oral nanocarriers for these biomolecules. Nanoparticles (NPs) based on gellan gum (GG) and retrograded starch...

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Bibliographic Details

Published in:	Journal of drug delivery science and technology Vol. 66; p. 102765
Main Authors:	Cardoso, Valéria Maria de Oliveira, Kiraly, Vanessa Thomaz Rodrigues, Boni, Fernanda Isadora, Ferreira, Natália Noronha, Ferreira, Leonardo M.B., Pereira, Fabíola Manhas Verbi, Borges, Júlio César, Cury, Beatriz Stringhetti Ferreira, Gremião, Maria Palmira Daflon
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-12-2021
Subjects:	ATR-FTIR Circular dichroism DSC Fluorescence Ionic cross-linking Polyelectrolyte complexation Polyelectrolyte complexation Fluorescence DSC ATR-FTIR Ionic cross-linking Circular dichroism
Online Access:	Get full text
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