Alterações respiratórias, auditivas e citogenéticas em trabalhadores de um estaleiro no Rio de Janeiro: estudo de caso

• Published in: Cadernos saúde coletiva Vol. 25; no. 4; pp. 394 - 404
• Main Authors: Murata, Marcos Massao, Isabele Campos Costa-Amaral, Leandro Vargas Barreto de Carvalho, Rodrigues de Souza, Gabriela, Helena Ramirez Domingos Mainenti, Márcia Aparecida Ribeiro de Carvalho, Valente, Daniel, Gilvania Barreto Feitosa Coutinho, Diane Francis Ribeiro do Vale, Camila do Nascimento Rodrigues, Patrícia Canto Ribeiro, Monica Stuck de Oliveira, Marco Antônio Carneiro Menezes, Liliane Reis Teixeira, Ariane Leites Larentis, Maria de Fátima Ramos Moreira, Márcia Soalheiro de Almeida, Hermano Albuquerque de Castro, Rita de Cássia Oliveira da Costa Mattos
• Format: Journal Article
• Language: English; Portuguese
• Published: Rio de Janeiro Instituto de Estudos em Saúde Coletiva da Universidade Federal do Rio de Janeiro 01-12-2017
• Subjects: aberrações cromossômicas; função pulmonar; metais; Perda Auditiva Induzida pelo Ruído (PAIR); Saúde do Trabalhador; Testes; Brazil; Rio de Janeiro Brazil
• ISSN: 1414-462X; 2358-291X
• DOI: 10.1590/1414-462X201700040324

IntroductionThis study evaluated respiratory, audiological and cytogenetic alterations in shipyard workers in Angra dos Reis, state of Rio de Janeiro/Brazil, and their correlation to the occupational exposure of painters to solvents, metals and noise present.MethodsWe evaluated pulmonary function, hearing loss and speech recognition, as well as cytogenetic alterations. Indicators of exposure to lead and manganese in blood were evaluated by atomic absorption spectrometry. The determination of ALAD and ALA-U was performed by spectrophotometry and liquid chromatography, respectively.ResultsSix of the 9 workers evaluated for lung function had respiratory functional impairment. Almost 70% of the 18 evaluated workers had reduced hearing, with association between PAIR and values of lead in blood. The average percentage of recovery of ALAD was 32.9%; average was 1.7 mg g-1 creatinine for ALA-U, 4.65 µg dL-1 for Pb-B and 10 µg L-1 for Mn-B. We observed associations between activated ALA-D with Mn-B and the presence of chromosomal aberrations. Furthermore, we identified cytogenetic alterations as aneuploidy, premature centromere separation; as well as ring formation, breakage, and sister chromatid union.ConclusionShipyard workers presented alterations that can be associated with occupational exposure.