STIMULATION OF PULMONARY ARTERIAL ENDOTHELIUM IN DIASTOLIC HEART FAILURE INDUCED PULMONARY HYPERTENSION SIMILAR TO PULMONARY ARTERIAL HYPERTENSION

STIMULATION OF PULMONARY ARTERIAL ENDOTHELIUM IN DIASTOLIC HEART FAILURE INDUCED PULMONARY HYPERTENSION SIMILAR TO PULMONARY ARTERIAL HYPERTENSION

Methods Prior to the initiation of treatment, PA levels of vWF Ag and F8 were measured during right heart cath (RHC) in consecutive patients with PAH (mPAP>25mmHg, PCWP<15mmHg, gradient diastolic PA-PCWP >5mmHg and, transpulmonary gradient [TPG] >12mmHg) and DHF-PH (clinical symptoms of...

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Bibliographic Details
Published in:Journal of the American College of Cardiology Vol. 61; no. 10; p. E675
Main Authors: Salamon, Jason N, Mazurek, Jeremy, Iqbal, Muhammad, Wartak, Siddharth, Zolty, Ronald
Format: Journal Article
Language:English
Published: New York Elsevier Inc 12-03-2013
Elsevier Limited
Subjects:
Cardiology
Cardiovascular
Drug therapy
Endothelium
Heart failure
Hemophilia
Internal Medicine
Pulmonary hypertension
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Summary:Methods Prior to the initiation of treatment, PA levels of vWF Ag and F8 were measured during right heart cath (RHC) in consecutive patients with PAH (mPAP>25mmHg, PCWP<15mmHg, gradient diastolic PA-PCWP >5mmHg and, transpulmonary gradient [TPG] >12mmHg) and DHF-PH (clinical symptoms of CHF, echo parameters consistent with diastolic dysfunction, left ventricular ejection fraction >=50% and PASP>35mmHg on TTE, RHC mPAP>25mmHg, gradient PA-diastolic PCWP <5mmHg and TPG <=12mmHg).
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(13)60675-0