A-186253, a specific antagonist of the α4β2 nAChRs: its properties and potential to study brain nicotinic acetylcholine receptors
Imaging the living brain and the distribution of the ligand gated channels that participate in the neurotransmission is one of the challenges that is hoped to bring new insights for the treatment of neurological diseases. Herein, we probed a new nicotinic derivative, A-186253 as a potential molecule...
Saved in:
| Published in: | Neuropharmacology Vol. 47; no. 4; pp. 538 - 557 |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier Ltd
01-09-2004
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Imaging the living brain and the distribution of the ligand gated channels that participate in the neurotransmission is one of the challenges that is hoped to bring new insights for the treatment of neurological diseases. Herein, we probed a new nicotinic derivative, A-186253 as a potential molecule to discriminate with high resolution the different neuronal nicotinic receptor subtypes that are expressed in distinct brain areas. Binding with a high affinity of 440 pM at the major brain α4β2 receptor subtype and presenting an excellent safety margin, properties of the A-186253 were thoroughly evaluated. While autoradiography confirmed its specificity for the α4β2 subtype, functional investigations revealed for short exposures a broader spectrum of action at receptors including the ganglionic α3β4 and the homomeric α7 subtypes. Specificity was, however, observed at α4β2 when receptors were exposed for several minutes with low concentration of the A-186253. In view of these promising results, the A-186253 was radiolabeled and tested in positron emission tomography on rats and pigs. Despite the high selectivity observed in vitro, the A-186253 displayed a complex binding profile and little displacement by the agonist cytisine. While the A-186253 can be valuable to discriminate receptor subtypes, improvements of this molecule must be brought for in vivo measurements. |
|---|---|
| AbstractList | Imaging the living brain and the distribution of the ligand gated channels that participate in the neurotransmission is one of the challenges that is hoped to bring new insights for the treatment of neurological diseases. Herein, we probed a new nicotinic derivative, A-186253 as a potential molecule to discriminate with high resolution the different neuronal nicotinic receptor subtypes that are expressed in distinct brain areas. Binding with a high affinity of 440 pM at the major brain α4β2 receptor subtype and presenting an excellent safety margin, properties of the A-186253 were thoroughly evaluated. While autoradiography confirmed its specificity for the α4β2 subtype, functional investigations revealed for short exposures a broader spectrum of action at receptors including the ganglionic α3β4 and the homomeric α7 subtypes. Specificity was, however, observed at α4β2 when receptors were exposed for several minutes with low concentration of the A-186253. In view of these promising results, the A-186253 was radiolabeled and tested in positron emission tomography on rats and pigs. Despite the high selectivity observed in vitro, the A-186253 displayed a complex binding profile and little displacement by the agonist cytisine. While the A-186253 can be valuable to discriminate receptor subtypes, improvements of this molecule must be brought for in vivo measurements. |
| Author | Prinz, Katja Schubiger, P.August Bertrand, Sonia Itier, Valérie Marguerat, Anouk Honer, Michael Westera, Gerrit Schönbächler, Roland Bunnelle, William H. Sullivan, James P. Bertrand, Daniel Meyer, Michael D. Tribollet, Eliane |
| Author_xml | – sequence: 1 givenname: Valérie surname: Itier fullname: Itier, Valérie organization: Department of Physiology, Medical Faculty, CMU, University of Geneva, 1, rue Michel Servet, CH-1211 Geneva 4, Switzerland – sequence: 2 givenname: Roland surname: Schönbächler fullname: Schönbächler, Roland organization: Center for Radiopharmaceutical Science, Swiss Federal Institute of Technology, Zurich, Switzerland – sequence: 3 givenname: Eliane surname: Tribollet fullname: Tribollet, Eliane organization: Department of Physiology, Medical Faculty, CMU, University of Geneva, 1, rue Michel Servet, CH-1211 Geneva 4, Switzerland – sequence: 4 givenname: Michael surname: Honer fullname: Honer, Michael organization: Center for Radiopharmaceutical Science, Swiss Federal Institute of Technology, Zurich, Switzerland – sequence: 5 givenname: Katja surname: Prinz fullname: Prinz, Katja organization: Center for Radiopharmaceutical Science, Swiss Federal Institute of Technology, Zurich, Switzerland – sequence: 6 givenname: Anouk surname: Marguerat fullname: Marguerat, Anouk organization: Department of Physiology, Medical Faculty, CMU, University of Geneva, 1, rue Michel Servet, CH-1211 Geneva 4, Switzerland – sequence: 7 givenname: Sonia surname: Bertrand fullname: Bertrand, Sonia organization: Department of Physiology, Medical Faculty, CMU, University of Geneva, 1, rue Michel Servet, CH-1211 Geneva 4, Switzerland – sequence: 8 givenname: William H. surname: Bunnelle fullname: Bunnelle, William H. organization: Abbott laboratories, USA – sequence: 9 givenname: P.August surname: Schubiger fullname: Schubiger, P.August organization: Center for Radiopharmaceutical Science, Swiss Federal Institute of Technology, Zurich, Switzerland – sequence: 10 givenname: Michael D. surname: Meyer fullname: Meyer, Michael D. organization: Abbott laboratories, USA – sequence: 11 givenname: James P. surname: Sullivan fullname: Sullivan, James P. organization: Abbott laboratories, USA – sequence: 12 givenname: Daniel surname: Bertrand fullname: Bertrand, Daniel email: daniel.bertrand@medecine.unige.ch organization: Department of Physiology, Medical Faculty, CMU, University of Geneva, 1, rue Michel Servet, CH-1211 Geneva 4, Switzerland – sequence: 13 givenname: Gerrit surname: Westera fullname: Westera, Gerrit organization: Center for Radiopharmaceutical Science, Swiss Federal Institute of Technology, Zurich, Switzerland |
| BookMark | eNqFkN1KAzEQhYNUsFbfIQ_grvnZbrLe1eIfFATR65DNTmxKmyxJKvTaJ9IH6TO5pYKXXg0M55yZ852jkQ8eEMKUlJTQ-npVetjG0C913JSMkKok05KQ-gSNqRS8EKSuRmhMCJMFb4g8Q-cprcgglFSO0eesoLJmU36FNU49GGedwdpn_R68SxkHi_MS8P6r2n8z7Gfz5Uu6wS4n3A9XIWYHadB3uA8ZfHZ6jXPAKW-7HW6jdh57Z0J2_hBrIO_WZhnWzgOOYKDPIaYLdGr1OsHl75ygt_u71_ljsXh-eJrPFoVhnObCmtYIxnWlqdWiMY1sGedMSGFrUYmWtbSz2nBqZU07wSmYhg9byRmvwHZ8guQx18SQUgSr-ug2Ou4UJeoAU63UH0x1gKnIVA0wB-vt0QrDfx8OokrGgTfQuaFGVl1w_4f8APfPh_w |
| CitedBy_id | crossref_primary_10_1021_ja8055326 crossref_primary_10_1111_j_1476_5381_2009_00613_x crossref_primary_10_1124_mol_105_021782 crossref_primary_10_1021_jm040219e crossref_primary_10_1111_j_1460_9568_2005_04150_x |
| Cites_doi | 10.1046/j.1471-4159.2003.01578.x 10.1016/0024-3205(96)00212-3 10.1007/BF00879673 10.1016/S0969-8051(01)00225-6 10.1016/S0968-0004(01)01921-1 10.1016/S0960-894X(98)00019-5 10.1016/S0065-3233(08)60652-X 10.1016/S0896-6273(00)80616-9 10.1007/s00259-001-0695-z 10.1038/sj.bjp.0702154 10.1016/0014-2999(93)90043-H 10.1523/JNEUROSCI.21-06-01819.2001 10.1002/syn.10087 10.1046/j.1528-1157.43.s.5.16.x 10.1016/S0301-0082(97)00034-8 10.1021/jm00398a028 10.1016/S0969-8051(98)00070-5 10.1002/syn.10180 10.1002/neu.10153 10.1016/S0024-3205(98)00240-9 10.1016/j.bmc.2003.09.042 10.1021/bi00407a015 10.1021/bi00004a026 10.1523/JNEUROSCI.18-12-04461.1998 10.1002/jps.2600830915 10.1007/BF02505755 10.1038/35077011 10.1046/j.1471-4159.1996.67010145.x 10.1016/0028-3908(93)90139-T 10.1523/JNEUROSCI.18-02-00648.1998 10.1016/S0306-4522(99)00160-8 10.1046/j.1471-4159.2002.00951.x 10.1523/JNEUROSCI.05-05-01307.1985 10.1016/S0969-8051(00)00080-9 10.1007/BF02996300 10.1146/annurev.ph.57.030195.002513 10.1034/j.1600-0404.2000.00304.x 10.1111/j.1432-1033.1995.tb20733.x 10.1016/S0021-9673(00)95610-3 10.1016/S0969-8051(97)00040-1 10.1016/S0987-7053(02)00294-0 |
| ContentType | Journal Article |
| Copyright | 2004 Elsevier Ltd |
| Copyright_xml | – notice: 2004 Elsevier Ltd |
| DBID | AAYXX CITATION |
| DOI | 10.1016/j.neuropharm.2004.05.006 |
| DatabaseName | CrossRef |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1873-7064 |
| EndPage | 557 |
| ExternalDocumentID | 10_1016_j_neuropharm_2004_05_006 S002839080400139X |
| GroupedDBID | --- --K --M -~X .55 .GJ .~1 0R~ 123 1B1 1RT 1~. 1~5 29N 3O- 4.4 41~ 457 4G. 53G 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AADPK AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATCM AAXLA AAXUO ABCQJ ABFNM ABFRF ABIVO ABJNI ABMAC ABXDB ABYKQ ABZDS ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADIYS ADMUD AEBSH AEFWE AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGUBO AGWIK AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AKRWK ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AQVPL ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC C45 CS3 DU5 EBS EFJIC EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMQ HMT HVGLF HZ~ IHE J1W K-O KOM L7B M2V M34 M41 MO0 MOBAO N9A O-L O9- OAUVE OGGZJ OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SCC SDF SDG SDP SES SEW SNS SPCBC SPT SSN SSP SSZ T5K TEORI WUQ X7M XOL ZGI ZXP ~G- AAXKI AAYXX AFJKZ CITATION |
| ID | FETCH-LOGICAL-c231t-fcbc723a4a1fa79c98b2332787f6747b2b1dfac31f861d731ec93b2b83234efd3 |
| ISSN | 0028-3908 |
| IngestDate | Thu Sep 26 15:17:49 EDT 2024 Tue Apr 02 10:07:20 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | Radiolabeling Electrophysiology Brain Autoradiography Neuronal nicotinic receptors Imaging |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c231t-fcbc723a4a1fa79c98b2332787f6747b2b1dfac31f861d731ec93b2b83234efd3 |
| PageCount | 20 |
| ParticipantIDs | crossref_primary_10_1016_j_neuropharm_2004_05_006 elsevier_sciencedirect_doi_10_1016_j_neuropharm_2004_05_006 |
| PublicationCentury | 2000 |
| PublicationDate | 2004-09-00 |
| PublicationDateYYYYMMDD | 2004-09-01 |
| PublicationDate_xml | – month: 09 year: 2004 text: 2004-09-00 |
| PublicationDecade | 2000 |
| PublicationTitle | Neuropharmacology |
| PublicationYear | 2004 |
| Publisher | Elsevier Ltd |
| Publisher_xml | – name: Elsevier Ltd |
| References | Quik, Choremis, Komourian, Lukas, Puchacz (BIB40) 1996; 67 Grutter, Changeux (BIB23) 2001; 26 Lin, Gunn, Li, He, Bai, Ryther, Kuntzweiler, Donnelly-Roberts, Anderson, Campbell, Sullivan, Arnesic, Holladay (BIB52) 1998; 8 Sullivan, Decker, Brioni, Donnelly-Roberts, Anderson, Bannon, Kang, Adams, Piattoni-Kaplan, Buckley (BIB48) 1994; 271 Spang, Patt, Westera, Schubiger (BIB46) 2000; 27 Langenbuch-Cachat, Bon, Mulle, Goeldner, Hirth, Changeux (BIB27) 1988; 27 Ding, Molina, Fowler, Logan, Volkow, Kuhar, Carroll (BIB17) 1999; 26 Breton, Pezzi, Molinari, Bonomini, Lansen, Gonzalez De Buitrago, Prieto (BIB7) 1995; 231 Bertrand, Picard, Le Hellard, Weiland, Favre, Phillips, Bertrand, Berkovic, Malafosse, Mulley (BIB3) 2002; 43 Young, Mitchell, Brown, Ganellin, Griffiths, Jones, Rana, Saunders, Smith, Sore (BIB49) 1988; 31 Perry, Xiao, Nguyen, Musachio, Davila-Garcia, Kellar (BIB38) 2002; 82 Burger, Buck (BIB9) 1997; 38 Itier, Bertrand (BIB24) 2002; 32 Brejc, van Dijk, Klaassen, Schuurmans, van Der Oost, Smit, Sixma (BIB6) 2001; 411 Zoli, Lena, Picciotto, Changeux (BIB50) 1998; 18 Fujita, Tamagnan, Zoghbi, Al-Tikriti, Baldwin, Seibyl, Innis (BIB19) 2000; 41 Blower, Clark, Link (BIB5) 1997; 24 Roger, Lagnel, Rouden, Besret, Valette, Demphel, Gopisetti, Coulon, Ottaviani, Wrenn, Letchworth, Bohme, Benavides, Lasne, Bottlaender, Dolle (BIB41) 2003; 11 Abraham, Chadha, Mitchell (BIB1) 1994; 83 Strijckmans, Coulon, Kassiou, Loc’h, Maziere (BIB47) 1996; 58 McGehee, Role (BIB33) 1995; 57 Devillers-Thiery, Galzi, Eisele, Bertrand, Bertrand, Changeux (BIB16) 1993; 136 Skok, Voitenko, Voitenko, Lykhmus, Kalashnik, Litvin, Tzartos, Skok (BIB45) 1999; 93 Jia, Flotildes, Li, Cohen (BIB51) 2003; 84 Papke, Heinemann (BIB35) 1994; 45 Qian, Li, Shen, Libertine-Garahan, Eckman, Biftu, Ip (BIB39) 1993; 250 Lundqvist, Langstrom, Nordberg (BIB31) 1997; 24 Clarke, Schwartz, Paul, Pert, Pert (BIB13) 1985; 5 Edelstein, Changeux (BIB18) 1998; 51 Lentz (BIB29) 1995; 34 Chavez-Noriega, Crona, Washburn, Urrutia, Elliott, Johnson (BIB11) 1997; 280 Fujita, Seibyl, Vaupel, Tamagnan, Early, Zoghbi, Baldwin, Horti, Kore, Mukhin, Khan, Bozkurt, Kimes, London, Innis (BIB20) 2002; 29 Gerzanich, Peng, Wang, Wells, Anand, Fletcher, Lindstrom (BIB21) 1995; 48 Seiler, Knodgen (BIB43) 1974; 97 Gotti, Fornasari, Clementi (BIB22) 1997; 53 Marks, Smith, Collins (BIB32) 1998; 285 Changeux, Edelstein (BIB10) 1998; 21 Saji, Ogawa, Ueda, Iida, Magata, Tominaga, Kawashima, Kitamura, Nakagawa, Kiyono, Mukai (BIB42) 2002; 16 Sihver, Langstrom, Nordberg (BIB44) 2000; 176 Chefer, London, Koren, Pavlova, Kurian, Kimes, Horti, Mukhin (BIB12) 2003; 48 Corringer, Bertrand, Galzi, Devillers-Thiery, Changeux, Bertrand (BIB15) 1999; 225 Le Novere, Corringer, Changeux (BIB28) 2002; 53 Loiacono, Stephenson, Stevenson, Mitchelson (BIB30) 1993; 32 Badio, Daly (BIB2) 1994; 45 Perry, Kellar (BIB37) 1995; 275 Corringer, Bertrand, Bohler, Edelstein, Changeux, Bertrand (BIB14) 1998; 18 Kassiou, Scheffel, Ravert, Mathews, Musachio, London, Dannals (BIB25) 1998; 63 Bertrand, Weiland, Berkovic, Steinlein, Bertrand (BIB4) 1998; 125 Buisson, Bertrand (BIB8) 2001; 21 Patt, Spang, Buck, Cristina, Arras, Schubiger, Westera (BIB36) 2001; 28 Kassiou, Bottlaender, Loc’h, Dolle, Musachio, Coulon, Ottaviani, Dannals, Maziere (BIB26) 2002; 45 Pabreza, Dhawan, Kellar (BIB34) 1991; 39 Brejc (10.1016/j.neuropharm.2004.05.006_BIB6) 2001; 411 Blower (10.1016/j.neuropharm.2004.05.006_BIB5) 1997; 24 Abraham (10.1016/j.neuropharm.2004.05.006_BIB1) 1994; 83 Roger (10.1016/j.neuropharm.2004.05.006_BIB41) 2003; 11 Clarke (10.1016/j.neuropharm.2004.05.006_BIB13) 1985; 5 Ding (10.1016/j.neuropharm.2004.05.006_BIB17) 1999; 26 Marks (10.1016/j.neuropharm.2004.05.006_BIB32) 1998; 285 Grutter (10.1016/j.neuropharm.2004.05.006_BIB23) 2001; 26 Pabreza (10.1016/j.neuropharm.2004.05.006_BIB34) 1991; 39 McGehee (10.1016/j.neuropharm.2004.05.006_BIB33) 1995; 57 Papke (10.1016/j.neuropharm.2004.05.006_BIB35) 1994; 45 Perry (10.1016/j.neuropharm.2004.05.006_BIB38) 2002; 82 Chavez-Noriega (10.1016/j.neuropharm.2004.05.006_BIB11) 1997; 280 Sullivan (10.1016/j.neuropharm.2004.05.006_BIB48) 1994; 271 Changeux (10.1016/j.neuropharm.2004.05.006_BIB10) 1998; 21 Chefer (10.1016/j.neuropharm.2004.05.006_BIB12) 2003; 48 Patt (10.1016/j.neuropharm.2004.05.006_BIB36) 2001; 28 Strijckmans (10.1016/j.neuropharm.2004.05.006_BIB47) 1996; 58 Bertrand (10.1016/j.neuropharm.2004.05.006_BIB4) 1998; 125 Fujita (10.1016/j.neuropharm.2004.05.006_BIB20) 2002; 29 Corringer (10.1016/j.neuropharm.2004.05.006_BIB14) 1998; 18 Skok (10.1016/j.neuropharm.2004.05.006_BIB45) 1999; 93 Jia (10.1016/j.neuropharm.2004.05.006_BIB51) 2003; 84 Kassiou (10.1016/j.neuropharm.2004.05.006_BIB26) 2002; 45 Perry (10.1016/j.neuropharm.2004.05.006_BIB37) 1995; 275 Le Novere (10.1016/j.neuropharm.2004.05.006_BIB28) 2002; 53 Kassiou (10.1016/j.neuropharm.2004.05.006_BIB25) 1998; 63 Spang (10.1016/j.neuropharm.2004.05.006_BIB46) 2000; 27 Qian (10.1016/j.neuropharm.2004.05.006_BIB39) 1993; 250 Corringer (10.1016/j.neuropharm.2004.05.006_BIB15) 1999; 225 Gerzanich (10.1016/j.neuropharm.2004.05.006_BIB21) 1995; 48 Bertrand (10.1016/j.neuropharm.2004.05.006_BIB3) 2002; 43 Quik (10.1016/j.neuropharm.2004.05.006_BIB40) 1996; 67 Breton (10.1016/j.neuropharm.2004.05.006_BIB7) 1995; 231 Seiler (10.1016/j.neuropharm.2004.05.006_BIB43) 1974; 97 Young (10.1016/j.neuropharm.2004.05.006_BIB49) 1988; 31 Edelstein (10.1016/j.neuropharm.2004.05.006_BIB18) 1998; 51 Lundqvist (10.1016/j.neuropharm.2004.05.006_BIB31) 1997; 24 Gotti (10.1016/j.neuropharm.2004.05.006_BIB22) 1997; 53 Saji (10.1016/j.neuropharm.2004.05.006_BIB42) 2002; 16 Burger (10.1016/j.neuropharm.2004.05.006_BIB9) 1997; 38 Itier (10.1016/j.neuropharm.2004.05.006_BIB24) 2002; 32 Zoli (10.1016/j.neuropharm.2004.05.006_BIB50) 1998; 18 Loiacono (10.1016/j.neuropharm.2004.05.006_BIB30) 1993; 32 Devillers-Thiery (10.1016/j.neuropharm.2004.05.006_BIB16) 1993; 136 Lentz (10.1016/j.neuropharm.2004.05.006_BIB29) 1995; 34 Langenbuch-Cachat (10.1016/j.neuropharm.2004.05.006_BIB27) 1988; 27 Badio (10.1016/j.neuropharm.2004.05.006_BIB2) 1994; 45 Buisson (10.1016/j.neuropharm.2004.05.006_BIB8) 2001; 21 Lin (10.1016/j.neuropharm.2004.05.006_BIB52) 1998; 8 Fujita (10.1016/j.neuropharm.2004.05.006_BIB19) 2000; 41 Sihver (10.1016/j.neuropharm.2004.05.006_BIB44) 2000; 176 |
| References_xml | – volume: 82 start-page: 468 year: 2002 end-page: 481 ident: BIB38 article-title: Measuring nicotinic receptors with characteristics of alpha4beta2, alpha3beta2 and alpha3beta4 subtypes in rat tissues by autoradiography publication-title: Journal of Neurochemistry contributor: fullname: Kellar – volume: 84 start-page: 753 year: 2003 end-page: 766 ident: BIB51 article-title: Nicotine trapping causes the persistant desensitization of alpha 4 beta 2 nicotinic receptors expressed in oocytes publication-title: Journal of Neurochemistry contributor: fullname: Cohen – volume: 32 start-page: 99 year: 2002 end-page: 107 ident: BIB24 article-title: Mutations of the neuronal nicotinic acetylcholine receptors and their association with ADNFLE publication-title: Neurophysiologie Clinique contributor: fullname: Bertrand – volume: 41 start-page: 1552 year: 2000 end-page: 1560 ident: BIB19 article-title: Measurement of alpha4beta2 nicotinic acetylcholine receptors with [123I]5-I-A-85380 SPECT publication-title: Journal of Nuclear Medicine contributor: fullname: Innis – volume: 58 start-page: L337 year: 1996 end-page: 344 ident: BIB47 article-title: In vitro pharmacological properties of 4-bromodexetimide for muscarinic receptors publication-title: Life Science contributor: fullname: Maziere – volume: 271 start-page: 624 year: 1994 end-page: 631 ident: BIB48 article-title: (+/−)-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors publication-title: Journal of Pharmacology and Experimental Therapeutics contributor: fullname: Buckley – volume: 93 start-page: 1427 year: 1999 end-page: 1436 ident: BIB45 article-title: Alpha subunit composition of nicotinic acetylcholine receptors in the rat autonomic ganglia neurons as determined with subunit-specific anti-alpha(181–192) peptide antibodies publication-title: Neuroscience contributor: fullname: Skok – volume: 18 start-page: 648 year: 1998 end-page: 657 ident: BIB14 article-title: Critical elements determining diversity in agonist binding and desensitization of neuronal nicotinic acetylcholine receptors publication-title: Journal of Neuroscience contributor: fullname: Bertrand – volume: 26 start-page: 139 year: 1999 end-page: 148 ident: BIB17 article-title: Comparative studies of epibatidine derivatives [18F]NFEP and [18F] publication-title: Nuclear Medicine Biology contributor: fullname: Carroll – volume: 176 start-page: 27 year: 2000 end-page: 33 ident: BIB44 article-title: Ligands for in vivo imaging of nicotinic receptor subtypes in Alzheimer brain publication-title: Acta Neurologica Scandinavica Supplementum contributor: fullname: Nordberg – volume: 48 start-page: 25 year: 2003 end-page: 34 ident: BIB12 article-title: Graphical analysis of 2-[18F]FA binding to nicotinic acetylcholine receptors in rhesus monkey brain publication-title: Synapse contributor: fullname: Mukhin – volume: 125 start-page: 751 year: 1998 end-page: 760 ident: BIB4 article-title: Properties of neuronal nicotinic acetylcholine receptor mutants from humans suffering from autosomal dominant nocturnal frontal lobe epilepsy publication-title: British Journal of Pharmacology contributor: fullname: Bertrand – volume: 97 start-page: 386 year: 1974 end-page: 388 ident: BIB43 article-title: Identification of amino acids in picomole amounts as their 5-dibutylaminonaphthalene-1-sulphonyl derivatives publication-title: Journal of Chromatography contributor: fullname: Knodgen – volume: 280 start-page: 346 year: 1997 end-page: 356 ident: BIB11 article-title: Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in publication-title: Journal of Pharmacology and Experimental Therapeutics contributor: fullname: Johnson – volume: 411 start-page: 269 year: 2001 end-page: 276 ident: BIB6 article-title: Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors publication-title: Nature contributor: fullname: Sixma – volume: 231 start-page: 563 year: 1995 end-page: 569 ident: BIB7 article-title: Prolonged half-life in the circulation of a chemical conjugate between a pro-urokinase derivative and human serum albumin publication-title: European Journal of Biochemistry contributor: fullname: Prieto – volume: 53 start-page: 447 year: 2002 end-page: 456 ident: BIB28 article-title: The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences publication-title: Journal of Neurobiology contributor: fullname: Changeux – volume: 45 start-page: 563 year: 1994 end-page: 569 ident: BIB2 article-title: Epibatidine, a potent analgetic and nicotinic agonist publication-title: Molecular Pharmacology contributor: fullname: Daly – volume: 29 start-page: 183 year: 2002 end-page: 190 ident: BIB20 article-title: Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123i]5-i-A-85380 in healthy human subjects publication-title: European Journal of Nuclear Medicine Molecular Imaging contributor: fullname: Innis – volume: 63 start-page: PL13, 18 year: 1998 ident: BIB25 article-title: Pharmacological evaluation of [11C]A-84543: an enantioselective ligand for in vivo studies of neuronal nicotinic acetylcholine receptors publication-title: Life Science contributor: fullname: Dannals – volume: 57 start-page: 521 year: 1995 end-page: 546 ident: BIB33 article-title: Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons publication-title: Annual Revue Physiology contributor: fullname: Role – volume: 48 start-page: 774 year: 1995 end-page: 782 ident: BIB21 article-title: Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors publication-title: Molecular Pharmacology contributor: fullname: Lindstrom – volume: 43 start-page: 112 year: 2002 end-page: 122 ident: BIB3 article-title: How mutations in the nAChRs can cause ADNFLE epilepsy publication-title: Epilepsia contributor: fullname: Mulley – volume: 39 start-page: 9 year: 1991 end-page: 12 ident: BIB34 article-title: [3H]cytisine binding to nicotinic cholinergic receptors in brain publication-title: Molecular Pharmacology contributor: fullname: Kellar – volume: 34 start-page: 1316 year: 1995 end-page: 1322 ident: BIB29 article-title: Differential binding of nicotine and alpha-bungarotoxin to residues 173–204 of the nicotinic acetylcholine receptor alpha 1 subunit publication-title: Biochemistry contributor: fullname: Lentz – volume: 24 start-page: 305 year: 1997 end-page: 310 ident: BIB5 article-title: Radioiodinated methylene blue for melanoma targeting: chemical characterisation and tumour selectivity of labelled components publication-title: Nuclear Medicine Biology contributor: fullname: Link – volume: 225 start-page: 215 year: 1999 end-page: 224 ident: BIB15 article-title: Molecular basis of the charge selectivity of nicotinic acetylcholine receptor and related ligand-gated ion channels publication-title: Novartis Foundation Symposium contributor: fullname: Bertrand – volume: 21 start-page: 1819 year: 2001 end-page: 1829 ident: BIB8 article-title: Chronic exposure to nicotine upregulates the human (alpha)4(beta)2 nicotinic acetylcholine receptor function publication-title: Journal of Neuroscience contributor: fullname: Bertrand – volume: 275 start-page: 1030 year: 1995 end-page: 1034 ident: BIB37 article-title: [3H]epibatidine labels nicotinic receptors in rat brain: an autoradiographic study publication-title: Journal of Pharmacology and Experimental Therapeutics contributor: fullname: Kellar – volume: 136 start-page: 97 year: 1993 end-page: 112 ident: BIB16 article-title: Functional architecture of the nicotinic acetylcholine receptor: a prototype of ligand-gated ion channels publication-title: Journal of Membrane Biology contributor: fullname: Changeux – volume: 250 start-page: R13 year: 1993 end-page: 14 ident: BIB39 article-title: Epibatidine is a nicotinic analgesic publication-title: European Journal of Pharmacology contributor: fullname: Ip – volume: 11 start-page: 5333 year: 2003 end-page: 5343 ident: BIB41 article-title: Synthesis of a [2-Pyridinyl-18F]-labelled fluoro derivative of (−)-Cytisine as a candidate radioligand for brain nicotinic alpha4beta2 receptor imaging with PET publication-title: Bioorganical Medicine Chemistry contributor: fullname: Dolle – volume: 285 start-page: 377 year: 1998 end-page: 386 ident: BIB32 article-title: Differential agonist inhibition identifies multiple epibatidine binding sites in mouse brain publication-title: Journal of Pharmacology and Experimental Therapeutics contributor: fullname: Collins – volume: 8 start-page: 249 year: 1998 end-page: 254 ident: BIB52 article-title: Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy] pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist publication-title: Bioorganic & Medicinal Chemistry Letters contributor: fullname: Holladay – volume: 26 start-page: 459 year: 2001 end-page: 463 ident: BIB23 article-title: Nicotinic receptors in wonderland publication-title: Trends Biochemistry Science contributor: fullname: Changeux – volume: 5 start-page: 1307 year: 1985 end-page: 1315 ident: BIB13 article-title: Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-alpha-bungarotoxin publication-title: Journal of Neuroscience contributor: fullname: Pert – volume: 67 start-page: 145 year: 1996 end-page: 154 ident: BIB40 article-title: Similarity between rat brain nicotinic alpha-bungarotoxin receptors and stably expressed alpha-bungarotoxin binding sites publication-title: Journal of Neurochemistry contributor: fullname: Puchacz – volume: 28 start-page: 645 year: 2001 end-page: 655 ident: BIB36 article-title: Synthesis and in vivo studies of the stereoisomers of publication-title: Nuclear Medicine Biology contributor: fullname: Westera – volume: 24 start-page: 825 year: 1997 end-page: 826 ident: BIB31 article-title: Use of carbon-11 nicotine in PET studies publication-title: European Journal of Nuclear Medicine Molecular Imaging contributor: fullname: Nordberg – volume: 45 start-page: 142 year: 1994 end-page: 149 ident: BIB35 article-title: Partial agonist properties of cytisine on neuronal nicotinic receptors containing the beta 2 subunit publication-title: Molecular Pharmacology contributor: fullname: Heinemann – volume: 38 start-page: 1818 year: 1997 end-page: 1823 ident: BIB9 article-title: Requirements and implementation of a flexible kinetic modeling tool publication-title: Journal of Nuclear Medicine contributor: fullname: Buck – volume: 45 start-page: 95 year: 2002 end-page: 104 ident: BIB26 article-title: Pharmacological evaluation of a Br-76 analog of epibatidine: a potent ligand for studying brain nicotinic acetylcholine receptors publication-title: Synapse contributor: fullname: Maziere – volume: 27 start-page: 239 year: 2000 end-page: 247 ident: BIB46 article-title: Comparison of publication-title: Nuclear Medicine Biology contributor: fullname: Schubiger – volume: 21 start-page: 959 year: 1998 end-page: 980 ident: BIB10 article-title: Allosteric receptors after 30 years publication-title: Neuron contributor: fullname: Edelstein – volume: 83 start-page: 1257 year: 1994 end-page: 1268 ident: BIB1 article-title: Hydrogen bonding. 33. Factors that influence the distribution of solutes between blood and brain publication-title: Journal of Pharmacological Science contributor: fullname: Mitchell – volume: 32 start-page: 847 year: 1993 end-page: 853 ident: BIB30 article-title: Multiple binding sites for nicotine receptor antagonists in inhibiting [3H](−)-nicotine binding in rat cortex publication-title: Neuropharmacology contributor: fullname: Mitchelson – volume: 27 start-page: 2337 year: 1988 end-page: 2345 ident: BIB27 article-title: Photoaffinity labeling of the acetylcholine binding sites on the nicotinic receptor by an aryldiazonium derivative publication-title: Biochemistry contributor: fullname: Changeux – volume: 16 start-page: 189 year: 2002 end-page: 200 ident: BIB42 article-title: Evaluation of radioiodinated 5-iodo-3-(2( publication-title: Annual Nuclear Medicine contributor: fullname: Mukai – volume: 18 start-page: 4461 year: 1998 end-page: 4472 ident: BIB50 article-title: Identification of four classes of brain nicotinic receptors using beta2 mutant mice publication-title: Journal of Neuroscience contributor: fullname: Changeux – volume: 31 start-page: 656 year: 1988 end-page: 671 ident: BIB49 article-title: Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists publication-title: Journal of Medicine Chemistry contributor: fullname: Sore – volume: 51 start-page: 121 year: 1998 end-page: 184 ident: BIB18 article-title: Allosteric transitions of the acetylcholine receptor publication-title: Advance Proteine Chemistry contributor: fullname: Changeux – volume: 53 start-page: 199 year: 1997 end-page: 237 ident: BIB22 article-title: Human neuronal nicotinic receptors publication-title: Progress in Neurobiology contributor: fullname: Clementi – volume: 84 start-page: 753 year: 2003 ident: 10.1016/j.neuropharm.2004.05.006_BIB51 article-title: Nicotine trapping causes the persistant desensitization of alpha 4 beta 2 nicotinic receptors expressed in oocytes publication-title: Journal of Neurochemistry doi: 10.1046/j.1471-4159.2003.01578.x contributor: fullname: Jia – volume: 58 start-page: L337 year: 1996 ident: 10.1016/j.neuropharm.2004.05.006_BIB47 article-title: In vitro pharmacological properties of 4-bromodexetimide for muscarinic receptors publication-title: Life Science doi: 10.1016/0024-3205(96)00212-3 contributor: fullname: Strijckmans – volume: 24 start-page: 825 year: 1997 ident: 10.1016/j.neuropharm.2004.05.006_BIB31 article-title: Use of carbon-11 nicotine in PET studies publication-title: European Journal of Nuclear Medicine Molecular Imaging doi: 10.1007/BF00879673 contributor: fullname: Lundqvist – volume: 39 start-page: 9 year: 1991 ident: 10.1016/j.neuropharm.2004.05.006_BIB34 article-title: [3H]cytisine binding to nicotinic cholinergic receptors in brain publication-title: Molecular Pharmacology contributor: fullname: Pabreza – volume: 28 start-page: 645 year: 2001 ident: 10.1016/j.neuropharm.2004.05.006_BIB36 article-title: Synthesis and in vivo studies of the stereoisomers of N-[11C]methyl-homoepibatidine publication-title: Nuclear Medicine Biology doi: 10.1016/S0969-8051(01)00225-6 contributor: fullname: Patt – volume: 26 start-page: 459 year: 2001 ident: 10.1016/j.neuropharm.2004.05.006_BIB23 article-title: Nicotinic receptors in wonderland publication-title: Trends Biochemistry Science doi: 10.1016/S0968-0004(01)01921-1 contributor: fullname: Grutter – volume: 8 start-page: 249 year: 1998 ident: 10.1016/j.neuropharm.2004.05.006_BIB52 article-title: Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy] pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist publication-title: Bioorganic & Medicinal Chemistry Letters doi: 10.1016/S0960-894X(98)00019-5 contributor: fullname: Lin – volume: 38 start-page: 1818 year: 1997 ident: 10.1016/j.neuropharm.2004.05.006_BIB9 article-title: Requirements and implementation of a flexible kinetic modeling tool publication-title: Journal of Nuclear Medicine contributor: fullname: Burger – volume: 51 start-page: 121 year: 1998 ident: 10.1016/j.neuropharm.2004.05.006_BIB18 article-title: Allosteric transitions of the acetylcholine receptor publication-title: Advance Proteine Chemistry doi: 10.1016/S0065-3233(08)60652-X contributor: fullname: Edelstein – volume: 21 start-page: 959 year: 1998 ident: 10.1016/j.neuropharm.2004.05.006_BIB10 article-title: Allosteric receptors after 30 years publication-title: Neuron doi: 10.1016/S0896-6273(00)80616-9 contributor: fullname: Changeux – volume: 29 start-page: 183 year: 2002 ident: 10.1016/j.neuropharm.2004.05.006_BIB20 article-title: Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123i]5-i-A-85380 in healthy human subjects publication-title: European Journal of Nuclear Medicine Molecular Imaging doi: 10.1007/s00259-001-0695-z contributor: fullname: Fujita – volume: 45 start-page: 563 year: 1994 ident: 10.1016/j.neuropharm.2004.05.006_BIB2 article-title: Epibatidine, a potent analgetic and nicotinic agonist publication-title: Molecular Pharmacology contributor: fullname: Badio – volume: 45 start-page: 142 year: 1994 ident: 10.1016/j.neuropharm.2004.05.006_BIB35 article-title: Partial agonist properties of cytisine on neuronal nicotinic receptors containing the beta 2 subunit publication-title: Molecular Pharmacology contributor: fullname: Papke – volume: 125 start-page: 751 year: 1998 ident: 10.1016/j.neuropharm.2004.05.006_BIB4 article-title: Properties of neuronal nicotinic acetylcholine receptor mutants from humans suffering from autosomal dominant nocturnal frontal lobe epilepsy publication-title: British Journal of Pharmacology doi: 10.1038/sj.bjp.0702154 contributor: fullname: Bertrand – volume: 250 start-page: R13 year: 1993 ident: 10.1016/j.neuropharm.2004.05.006_BIB39 article-title: Epibatidine is a nicotinic analgesic publication-title: European Journal of Pharmacology doi: 10.1016/0014-2999(93)90043-H contributor: fullname: Qian – volume: 21 start-page: 1819 year: 2001 ident: 10.1016/j.neuropharm.2004.05.006_BIB8 article-title: Chronic exposure to nicotine upregulates the human (alpha)4(beta)2 nicotinic acetylcholine receptor function publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.21-06-01819.2001 contributor: fullname: Buisson – volume: 45 start-page: 95 year: 2002 ident: 10.1016/j.neuropharm.2004.05.006_BIB26 article-title: Pharmacological evaluation of a Br-76 analog of epibatidine: a potent ligand for studying brain nicotinic acetylcholine receptors publication-title: Synapse doi: 10.1002/syn.10087 contributor: fullname: Kassiou – volume: 43 start-page: 112 year: 2002 ident: 10.1016/j.neuropharm.2004.05.006_BIB3 article-title: How mutations in the nAChRs can cause ADNFLE epilepsy publication-title: Epilepsia doi: 10.1046/j.1528-1157.43.s.5.16.x contributor: fullname: Bertrand – volume: 53 start-page: 199 year: 1997 ident: 10.1016/j.neuropharm.2004.05.006_BIB22 article-title: Human neuronal nicotinic receptors publication-title: Progress in Neurobiology doi: 10.1016/S0301-0082(97)00034-8 contributor: fullname: Gotti – volume: 275 start-page: 1030 year: 1995 ident: 10.1016/j.neuropharm.2004.05.006_BIB37 article-title: [3H]epibatidine labels nicotinic receptors in rat brain: an autoradiographic study publication-title: Journal of Pharmacology and Experimental Therapeutics contributor: fullname: Perry – volume: 31 start-page: 656 year: 1988 ident: 10.1016/j.neuropharm.2004.05.006_BIB49 article-title: Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists publication-title: Journal of Medicine Chemistry doi: 10.1021/jm00398a028 contributor: fullname: Young – volume: 26 start-page: 139 year: 1999 ident: 10.1016/j.neuropharm.2004.05.006_BIB17 article-title: Comparative studies of epibatidine derivatives [18F]NFEP and [18F]N-methyl-NFEP: kinetics, nicotine effect, and toxicity publication-title: Nuclear Medicine Biology doi: 10.1016/S0969-8051(98)00070-5 contributor: fullname: Ding – volume: 48 start-page: 25 year: 2003 ident: 10.1016/j.neuropharm.2004.05.006_BIB12 article-title: Graphical analysis of 2-[18F]FA binding to nicotinic acetylcholine receptors in rhesus monkey brain publication-title: Synapse doi: 10.1002/syn.10180 contributor: fullname: Chefer – volume: 53 start-page: 447 year: 2002 ident: 10.1016/j.neuropharm.2004.05.006_BIB28 article-title: The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences publication-title: Journal of Neurobiology doi: 10.1002/neu.10153 contributor: fullname: Le Novere – volume: 285 start-page: 377 year: 1998 ident: 10.1016/j.neuropharm.2004.05.006_BIB32 article-title: Differential agonist inhibition identifies multiple epibatidine binding sites in mouse brain publication-title: Journal of Pharmacology and Experimental Therapeutics contributor: fullname: Marks – volume: 63 start-page: PL13, 18 year: 1998 ident: 10.1016/j.neuropharm.2004.05.006_BIB25 article-title: Pharmacological evaluation of [11C]A-84543: an enantioselective ligand for in vivo studies of neuronal nicotinic acetylcholine receptors publication-title: Life Science doi: 10.1016/S0024-3205(98)00240-9 contributor: fullname: Kassiou – volume: 11 start-page: 5333 year: 2003 ident: 10.1016/j.neuropharm.2004.05.006_BIB41 article-title: Synthesis of a [2-Pyridinyl-18F]-labelled fluoro derivative of (−)-Cytisine as a candidate radioligand for brain nicotinic alpha4beta2 receptor imaging with PET publication-title: Bioorganical Medicine Chemistry doi: 10.1016/j.bmc.2003.09.042 contributor: fullname: Roger – volume: 271 start-page: 624 year: 1994 ident: 10.1016/j.neuropharm.2004.05.006_BIB48 article-title: (+/−)-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors publication-title: Journal of Pharmacology and Experimental Therapeutics contributor: fullname: Sullivan – volume: 27 start-page: 2337 year: 1988 ident: 10.1016/j.neuropharm.2004.05.006_BIB27 article-title: Photoaffinity labeling of the acetylcholine binding sites on the nicotinic receptor by an aryldiazonium derivative publication-title: Biochemistry doi: 10.1021/bi00407a015 contributor: fullname: Langenbuch-Cachat – volume: 34 start-page: 1316 year: 1995 ident: 10.1016/j.neuropharm.2004.05.006_BIB29 article-title: Differential binding of nicotine and alpha-bungarotoxin to residues 173–204 of the nicotinic acetylcholine receptor alpha 1 subunit publication-title: Biochemistry doi: 10.1021/bi00004a026 contributor: fullname: Lentz – volume: 18 start-page: 4461 year: 1998 ident: 10.1016/j.neuropharm.2004.05.006_BIB50 article-title: Identification of four classes of brain nicotinic receptors using beta2 mutant mice publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.18-12-04461.1998 contributor: fullname: Zoli – volume: 83 start-page: 1257 year: 1994 ident: 10.1016/j.neuropharm.2004.05.006_BIB1 article-title: Hydrogen bonding. 33. Factors that influence the distribution of solutes between blood and brain publication-title: Journal of Pharmacological Science doi: 10.1002/jps.2600830915 contributor: fullname: Abraham – volume: 48 start-page: 774 year: 1995 ident: 10.1016/j.neuropharm.2004.05.006_BIB21 article-title: Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors publication-title: Molecular Pharmacology contributor: fullname: Gerzanich – volume: 136 start-page: 97 year: 1993 ident: 10.1016/j.neuropharm.2004.05.006_BIB16 article-title: Functional architecture of the nicotinic acetylcholine receptor: a prototype of ligand-gated ion channels publication-title: Journal of Membrane Biology doi: 10.1007/BF02505755 contributor: fullname: Devillers-Thiery – volume: 411 start-page: 269 year: 2001 ident: 10.1016/j.neuropharm.2004.05.006_BIB6 article-title: Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors publication-title: Nature doi: 10.1038/35077011 contributor: fullname: Brejc – volume: 280 start-page: 346 year: 1997 ident: 10.1016/j.neuropharm.2004.05.006_BIB11 article-title: Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes publication-title: Journal of Pharmacology and Experimental Therapeutics contributor: fullname: Chavez-Noriega – volume: 67 start-page: 145 year: 1996 ident: 10.1016/j.neuropharm.2004.05.006_BIB40 article-title: Similarity between rat brain nicotinic alpha-bungarotoxin receptors and stably expressed alpha-bungarotoxin binding sites publication-title: Journal of Neurochemistry doi: 10.1046/j.1471-4159.1996.67010145.x contributor: fullname: Quik – volume: 32 start-page: 847 year: 1993 ident: 10.1016/j.neuropharm.2004.05.006_BIB30 article-title: Multiple binding sites for nicotine receptor antagonists in inhibiting [3H](−)-nicotine binding in rat cortex publication-title: Neuropharmacology doi: 10.1016/0028-3908(93)90139-T contributor: fullname: Loiacono – volume: 18 start-page: 648 year: 1998 ident: 10.1016/j.neuropharm.2004.05.006_BIB14 article-title: Critical elements determining diversity in agonist binding and desensitization of neuronal nicotinic acetylcholine receptors publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.18-02-00648.1998 contributor: fullname: Corringer – volume: 93 start-page: 1427 year: 1999 ident: 10.1016/j.neuropharm.2004.05.006_BIB45 article-title: Alpha subunit composition of nicotinic acetylcholine receptors in the rat autonomic ganglia neurons as determined with subunit-specific anti-alpha(181–192) peptide antibodies publication-title: Neuroscience doi: 10.1016/S0306-4522(99)00160-8 contributor: fullname: Skok – volume: 225 start-page: 215 year: 1999 ident: 10.1016/j.neuropharm.2004.05.006_BIB15 article-title: Molecular basis of the charge selectivity of nicotinic acetylcholine receptor and related ligand-gated ion channels publication-title: Novartis Foundation Symposium contributor: fullname: Corringer – volume: 82 start-page: 468 year: 2002 ident: 10.1016/j.neuropharm.2004.05.006_BIB38 article-title: Measuring nicotinic receptors with characteristics of alpha4beta2, alpha3beta2 and alpha3beta4 subtypes in rat tissues by autoradiography publication-title: Journal of Neurochemistry doi: 10.1046/j.1471-4159.2002.00951.x contributor: fullname: Perry – volume: 41 start-page: 1552 year: 2000 ident: 10.1016/j.neuropharm.2004.05.006_BIB19 article-title: Measurement of alpha4beta2 nicotinic acetylcholine receptors with [123I]5-I-A-85380 SPECT publication-title: Journal of Nuclear Medicine contributor: fullname: Fujita – volume: 5 start-page: 1307 year: 1985 ident: 10.1016/j.neuropharm.2004.05.006_BIB13 article-title: Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-alpha-bungarotoxin publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.05-05-01307.1985 contributor: fullname: Clarke – volume: 27 start-page: 239 year: 2000 ident: 10.1016/j.neuropharm.2004.05.006_BIB46 article-title: Comparison of N-[(11)C]methyl-norchloroepibatidine and N-[(11)C]methyl-2-(2-pyridyl)-7-azabicyclo[2.2.1]heptane with N-[(11)C]methyl-epibatidine in small animal PET studies publication-title: Nuclear Medicine Biology doi: 10.1016/S0969-8051(00)00080-9 contributor: fullname: Spang – volume: 16 start-page: 189 year: 2002 ident: 10.1016/j.neuropharm.2004.05.006_BIB42 article-title: Evaluation of radioiodinated 5-iodo-3-(2(S)-azetidinylmethoxy)pyridine as a ligand for SPECT investigations of brain nicotinic acetylcholine receptors publication-title: Annual Nuclear Medicine doi: 10.1007/BF02996300 contributor: fullname: Saji – volume: 57 start-page: 521 year: 1995 ident: 10.1016/j.neuropharm.2004.05.006_BIB33 article-title: Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons publication-title: Annual Revue Physiology doi: 10.1146/annurev.ph.57.030195.002513 contributor: fullname: McGehee – volume: 176 start-page: 27 year: 2000 ident: 10.1016/j.neuropharm.2004.05.006_BIB44 article-title: Ligands for in vivo imaging of nicotinic receptor subtypes in Alzheimer brain publication-title: Acta Neurologica Scandinavica Supplementum doi: 10.1034/j.1600-0404.2000.00304.x contributor: fullname: Sihver – volume: 231 start-page: 563 year: 1995 ident: 10.1016/j.neuropharm.2004.05.006_BIB7 article-title: Prolonged half-life in the circulation of a chemical conjugate between a pro-urokinase derivative and human serum albumin publication-title: European Journal of Biochemistry doi: 10.1111/j.1432-1033.1995.tb20733.x contributor: fullname: Breton – volume: 97 start-page: 386 year: 1974 ident: 10.1016/j.neuropharm.2004.05.006_BIB43 article-title: Identification of amino acids in picomole amounts as their 5-dibutylaminonaphthalene-1-sulphonyl derivatives publication-title: Journal of Chromatography doi: 10.1016/S0021-9673(00)95610-3 contributor: fullname: Seiler – volume: 24 start-page: 305 year: 1997 ident: 10.1016/j.neuropharm.2004.05.006_BIB5 article-title: Radioiodinated methylene blue for melanoma targeting: chemical characterisation and tumour selectivity of labelled components publication-title: Nuclear Medicine Biology doi: 10.1016/S0969-8051(97)00040-1 contributor: fullname: Blower – volume: 32 start-page: 99 year: 2002 ident: 10.1016/j.neuropharm.2004.05.006_BIB24 article-title: Mutations of the neuronal nicotinic acetylcholine receptors and their association with ADNFLE publication-title: Neurophysiologie Clinique doi: 10.1016/S0987-7053(02)00294-0 contributor: fullname: Itier |
| SSID | ssj0004818 |
| Score | 1.8269439 |
| Snippet | Imaging the living brain and the distribution of the ligand gated channels that participate in the neurotransmission is one of the challenges that is hoped to... |
| SourceID | crossref elsevier |
| SourceType | Aggregation Database Publisher |
| StartPage | 538 |
| SubjectTerms | Autoradiography Brain Electrophysiology Imaging Neuronal nicotinic receptors Radiolabeling |
| Title | A-186253, a specific antagonist of the α4β2 nAChRs: its properties and potential to study brain nicotinic acetylcholine receptors |
| URI | https://dx.doi.org/10.1016/j.neuropharm.2004.05.006 |
| Volume | 47 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lj9MwELa63TPiKZaXfGD3kgbFidskcOqWoi4HtKIF9RbZjrMPrZKqmz3smV8EP2R_EzN2nARYCRDiklZuk1Ser-PxZL5vCHmJbI845Lk_EYH0OePaT2Qq_TzlLNVcqjRAvvNiGX9YJ2_nfD4YuJ5t3dh_tTSMga2ROfsX1m4vCgPwHmwOR7A6HP_I7lOfwfYBu0zMPOEhkRKLgTyYQHFSoUyuqwrYn833Dxk3L2HoldPZ6UdTH4ePEjaYo9-i2KpVEqhqrCrCwvTKKtJ6EntLeCUAqUZupSeUrq8v0Jli3Ap-VG-wkU8_-DVCIJtOK7vN5h_BjQxyPosL--R-e9YCbqlOcexwUkrzGVdtw-aq6T9icw_bM4lZkLqpVhNdwcCiamg9fZKAS3Xwtparyb85Dk5X8GT5CIkfpYH14tq68SSO_Diw-ujOz1tlzwbPvOe0x1HSW__HVjD7l6XFZjnOX5XtXJnsgtF9DX5S8zbxwdL0gYIfhn4SAu31DtkNwR2Oh2R3ejRfv-_4uwlLnFo4ntBUnNk6xNvvd3sY1QuNVnfJnWZPQ6cWjPfIQJf3ycGxNfT1iK46jt_liB7Q4x4EHpAvDrEjKqjDK-3wSquCAl7pzVd-8y2kFqevKaCUdiiF7-e0RSmtK2pQSg1KaYtS-gNKaYvSh-TTu_lqtvCb1iC-gg1J7RdKqjiMBBesEHGq0kSGURTC6lNMYIMsQ8nyQqiIFcmE5XHEtEojGIX1K-K6yKNHZFgC9h4TqlQskE6eg7PisWKwIdI6UUXB8jCHNWqPMDfT2cYqwGSuNPI866yDDV15FowzsM4eeeNMkjWRrI1QM0DTb89-8k9nP8XUE-YI8b_zjAzr7ZV-TnYu86sXDe6-AxYPyBY |
| link.rule.ids | 315,782,786,27935,27936 |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A-186253%2C+a+specific+antagonist+of+the+%CE%B14%CE%B22+nAChRs%3A+its+properties+and+potential+to+study+brain+nicotinic+acetylcholine+receptors&rft.jtitle=Neuropharmacology&rft.au=Itier%2C+Val%C3%A9rie&rft.au=Sch%C3%B6nb%C3%A4chler%2C+Roland&rft.au=Tribollet%2C+Eliane&rft.au=Honer%2C+Michael&rft.date=2004-09-01&rft.pub=Elsevier+Ltd&rft.issn=0028-3908&rft.eissn=1873-7064&rft.volume=47&rft.issue=4&rft.spage=538&rft.epage=557&rft_id=info:doi/10.1016%2Fj.neuropharm.2004.05.006&rft.externalDocID=S002839080400139X |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-3908&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-3908&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-3908&client=summon |