Fatal SARS-CoV-2-Associated Panton-Valentine Leukocidin-producing Staphylococcal Bacteremia: A Nationwide Multicenter Cohort Study

• Published in: The Pediatric infectious disease journal Vol. 41; no. 4; pp. e142 - e145
• Main Authors: Nygaard, Ulrikka, Petersen, Andreas, Larsen, Anders Rhod, Rytter, Maren Johanne Heilskov, Hartling, Ulla, Kirkby, Nikolai, Hansen, Rikke Nymark, Nielsen, Allan Bybeck, Lundstrøm, Kaare, Holm, Mette, Vissing, Nadja Hawwa
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 01-04-2022
• Subjects: Adolescent; Bacteremia; Bacterial Toxins - biosynthesis; Child; Child, Preschool; Coinfection; Comorbidity; COVID-19 - complications; COVID-19 - virology; Denmark - epidemiology; Exotoxins - biosynthesis; Female; Humans; Infant; Leukocidins - biosynthesis; Male; Methicillin-Resistant Staphylococcus aureus - genetics; Methicillin-Resistant Staphylococcus aureus - metabolism; Public Health Surveillance; SARS-CoV-2; Severity of Illness Index; Staphylococcal Infections - diagnosis; Staphylococcal Infections - etiology; Staphylococcal Infections - mortality; Staphylococcal Infections - therapy; Staphylococcus aureus - drug effects; Staphylococcus aureus - genetics; Staphylococcus aureus - metabolism; Denmark
• ISSN: 0891-3668; 1532-0987
• DOI: 10.1097/INF.0000000000003476

We reviewed all cases of Panton-Valentine leukocidin-producing Staphylococcus aureus (PVL-SA) bacteremia in Danish children between 2016 and 2021. We found 2 fatal cases with preceding viral prodrome due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given the usual benign course of SARS-CoV-2 infection in children, awareness of possible superinfection with PVL-SA in a child with rapid deterioration is crucial to ensure adequate treatment, including antimicrobial drugs with antitoxin effect.