Acute hypoxic hypoxia alters GABAA receptor modulation by allopregnanolone and pentobarbital in embryonic chick optic lobe
Using a previously developed model of acute normobaric hypoxic hypoxia on chick embryos, here we studied at embryonic day 12 the in vitro effect of two positive allosteric modulators of GABA binding, the barbiturate sodium pentobarbital and the neurosteroid allopregnanolone. In both cases an increas...
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| Published in: | Brain research Vol. 954; no. 2; pp. 294 - 299 |
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| Abstract | Using a previously developed model of acute normobaric hypoxic hypoxia on chick embryos, here we studied at embryonic day 12 the in vitro effect of two positive allosteric modulators of GABA binding, the barbiturate sodium pentobarbital and the neurosteroid allopregnanolone. In both cases an increase in Emax values in membranes obtained from hypoxic embryos was observed. Studies of GABA-gated chloride influx showed that there were no differences in maximal chloride uptake between hypoxic and control membranes. We have already demonstrated that maximal density of GABA binding sites was decreased after hypoxia, suggesting that each of the remaining GABAA receptors display a greater chloride flux than controls. To further characterize GABAA receptor alterations, GABA-gated chloride influx modulated by the above barbiturate and neurosteroid was determined, finding that Emax values were increased 60% and 42%, respectively. The increase in Cl super(-) influx per receptor subsequent to hypoxic trauma, and the enhancement in the modulatory properties studied, may mediate neuronal damage by potential changes in subunit interaction at the GABAA receptor level. |
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| AbstractList | Using a previously developed model of acute normobaric hypoxic hypoxia on chick embryos, here we studied at embryonic day 12 the in vitro effect of two positive allosteric modulators of GABA binding, the barbiturate sodium pentobarbital and the neurosteroid allopregnanolone. In both cases an increase in Emax values in membranes obtained from hypoxic embryos was observed. Studies of GABA-gated chloride influx showed that there were no differences in maximal chloride uptake between hypoxic and control membranes. We have already demonstrated that maximal density of GABA binding sites was decreased after hypoxia, suggesting that each of the remaining GABAA receptors display a greater chloride flux than controls. To further characterize GABAA receptor alterations, GABA-gated chloride influx modulated by the above barbiturate and neurosteroid was determined, finding that Emax values were increased 60% and 42%, respectively. The increase in Cl super(-) influx per receptor subsequent to hypoxic trauma, and the enhancement in the modulatory properties studied, may mediate neuronal damage by potential changes in subunit interaction at the GABAA receptor level. |
| Author | RODRIGUEZ GIL, D. J MITRIDATE DE NOVARA, A DE PLAZAS, S. Fiszer |
| Author_xml | – sequence: 1 givenname: D. J surname: RODRIGUEZ GIL fullname: RODRIGUEZ GIL, D. J organization: Instituto de Biología Celular y Neurosciencias, Professor E. De Robertis, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires, Argentina – sequence: 2 givenname: A surname: MITRIDATE DE NOVARA fullname: MITRIDATE DE NOVARA, A organization: Instituto de Biología Celular y Neurosciencias, Professor E. De Robertis, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires, Argentina – sequence: 3 givenname: S. Fiszer surname: DE PLAZAS fullname: DE PLAZAS, S. Fiszer organization: Instituto de Biología Celular y Neurosciencias, Professor E. De Robertis, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires, Argentina |
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| Keywords | Embryonic development Oxygen Embryo Acute Barbiturate Environmental factor CNS Neurosteroid Pregnanolone Optic lobe Vertebrata Pentobarbital Hypoxia Chicken Aves GABAA receptor Gabaergic receptor A |
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| Title | Acute hypoxic hypoxia alters GABAA receptor modulation by allopregnanolone and pentobarbital in embryonic chick optic lobe |
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