Antinociceptive activity of Ipomoea imperati (Vahl) Griseb., Convolvulaceae

Antinociceptive activity of Ipomoea imperati (Vahl) Griseb., Convolvulaceae

Ipomoea imperati (Vahl) Griseb., Convolvulaceae, is used in folk medicine for the treatment of inflammation, swelling and wounds, as well as to treat pains after childbirth and for stomach problems. Administration of ethanol extract, lipid and aqueous fraction of I. imperati(300, 100 and 200 mg/kg)...

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Bibliographic Details
Published in:Revista brasileira de farmacognosia Vol. 20; no. 2; pp. 180 - 185
Main Authors: Paula-Zurron, Ana Claudia B. De, Petraglia, Nilva M. M. A., Aur, Carlos R., Moura, Sérgio H. P., Imamura, Paulo M., Freitas, José C. De, Catanzaro-Guimarães, Sérgio A.
Format: Journal Article
Language:English
Published: Sociedade Brasileira de Farmacognosia 01-05-2010
Subjects:
PHARMACOLOGY & PHARMACY
sistema opioide
pain
Ipomoea imperati
opioid system
dor
atividade analgésica
analgesic activity
Convolvulaceae
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Summary:Ipomoea imperati (Vahl) Griseb., Convolvulaceae, is used in folk medicine for the treatment of inflammation, swelling and wounds, as well as to treat pains after childbirth and for stomach problems. Administration of ethanol extract, lipid and aqueous fraction of I. imperati(300, 100 and 200 mg/kg) significantly inhibited the abdominal constriction in mice induced by acetic acid; increased the sleeping time evoked by pentobarbital sodium and showed a significant activity by inhibiting formalin-induced paw edema in mice. The same dose of I. imperatialso raised the pain of mice in the hot-plate test and increased the latency at all observation times. The pre-treatment of the animals with naloxone (5 mg/kg, i.p.) suggested the participation of the opioid system in the antinociceptive effect of Ipomoea imperati.
ISSN:0102-695X
1981-528X
DOI:10.1590/S0102-695X2010000200008