Systematic Analysis of Homologous Recombination Deficiency Testing in Ovarian Cancer—Development of Recommendations for Optimal Assay Performance

Homologous recombination deficiency (HRD) assays are an important element of personalized oncology in ovarian carcinomas, but the optimal tissue requirements for these complex molecular assays remain unclear. As a result, a considerable percentage of assays are not successful, leading to suboptimal...

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Bibliographic Details
Published in:	Modern pathology Vol. 37; no. 4; p. 100445
Main Authors:	Romey, Marcel, Rodepeter, Fiona, Hattesohl, Akira, Kaiser, Kristin, Teply-Szymanski, Julia, Heitz, Florian, Staebler, Annette, Serra, Violeta, Grass, Albert, Marmé, Frederik, Timms, Kirsten M., Harter, Philipp, Llop-Guevara, Alba, Kommoss, Stefan, Boekhoff, Jelena, Denkert, Carsten
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-04-2024
Subjects:	BRCA BRCA1 Protein - genetics BRCA2 Protein - genetics Female Genomic Instability histology Homologous Recombination homologous recombination deficiency Humans Mutation ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology BRCA histology ovarian cancer homologous recombination deficiency
Online Access:	Get full text
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