TNF-alpha Down-Regulates Filaggrin and Loricrin Through c-Jun N-Terminal Kinase: Role for TNF Antagonists to Improve Skin Barrier

TNF-alpha Down-Regulates Filaggrin and Loricrin Through c-Jun N-Terminal Kinase: Role for TNF Antagonists to Improve Skin Barrier

Psoriasis is characterized by over-expression of TNF-alpha and impaired skin barrier. [...]we investigated whether skin barrier proteins are modulated by TNF-alpha, and determined the effect of clinical treatment with a TNF-alpha antagonist on barrier protein expression.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology Vol. 127; no. 2; p. AB148
Main Authors: Kim, B.E, Howell, M.D, Guttman, E, Gilleaudeau, P, Cardinale, I, Boguniewicz, M, Krueger, J.G, Leung, D.Y
Format: Journal Article
Language:English
Published: St. Louis Mosby, Inc 01-02-2011
Elsevier Limited
Subjects:
Allergy and Immunology
Biopsy
Drug therapy
Protein expression
Proteins
Psoriasis
Online Access:Get full text
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Description
Summary:Psoriasis is characterized by over-expression of TNF-alpha and impaired skin barrier. [...]we investigated whether skin barrier proteins are modulated by TNF-alpha, and determined the effect of clinical treatment with a TNF-alpha antagonist on barrier protein expression.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2010.12.588