Auto-Abs neutralizing type I IFNs in patients with severe Powassan, Usutu, or Ross River virus disease

• Published in: The Journal of experimental medicine Vol. 221; no. 12
• Main Authors: Gervais, Adrian, Bastard, Paul, Bizien, Lucy, Delifer, Céline, Tiberghien, Pierre, Rodrigo, Chaturaka, Trespidi, Francesca, Angelini, Micol, Rossini, Giada, Lazzarotto, Tiziana, Conti, Francesca, Cassaniti, Irene, Baldanti, Fausto, Rovida, Francesca, Ferrari, Alessandro, Mileto, Davide, Mancon, Alessandro, Abel, Laurent, Puel, Anne, Cobat, Aurélie, Rice, Charles M, Cadar, Dániel, Schmidt-Chanasit, Jonas, Scheid, Johannes F, Lemieux, Jacob E, Rosenberg, Eric S, Agudelo, Marianna, Tangye, Stuart G, Borghesi, Alessandro, Durand, Guillaume André, Duburcq-Gury, Emilie, Valencia, Braulio M, Lloyd, Andrew R, Nagy, Anna, MacDonald, Margaret M, Simonin, Yannick, Zhang, Shen-Ying, Casanova, Jean-Laurent
• Format: Journal Article
• Language: English
• Published: United States 02-12-2024
• Subjects: Adult; Aged; Alphavirus Infections - immunology; Antibodies, Neutralizing - immunology; Autoantibodies - immunology; Encephalitis Viruses, Tick-Borne - immunology; Encephalitis, Tick-Borne - immunology; Encephalitis, Tick-Borne - virology; Female; Flavivirus; Humans; Interferon Type I - immunology; Male; Middle Aged; Ross River virus - immunology; Ross River Virus Infection
• ISSN: 1540-9538
• DOI: 10.1084/jem.20240942

Arboviral diseases are a growing global health concern. Pre-existing autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) can underlie encephalitis due to West Nile virus (WNV) (∼40% of patients) and tick-borne encephalitis (TBE, due to TBE virus [TBEV]) (∼10%). We report here that these auto-Abs can also underlie severe forms of rarer arboviral infections. Auto-Abs neutralizing high concentrations of IFN-α2, IFN-β, and/or IFN-ω are present in the single case of severe Powassan virus (POWV) encephalitis studied, two of three cases of severe Usutu virus (USUV) infection studied, and the most severe of 24 cases of Ross River virus (RRV) disease studied. These auto-Abs are not found in any of the 137 individuals with silent or mild infections with these three viruses. Thus, auto-Abs neutralizing type I IFNs underlie an increasing list of severe arboviral diseases due to Flaviviridae (WNV, TBEV, POWV, USUV) or Togaviridae (RRV) viruses transmitted to humans by mosquitos (WNV, USUV, RRV) or ticks (TBEV, POWV).