BnSP-7 toxin, a basic phospholipase A2 from Bothrops pauloensis snake venom, interferes with proliferation, ultrastructure and infectivity of Leishmania (Leishmania) amazonensis

This paper reports the effects of BnSP-7 toxin, a catalytically inactive phospholipase A2 from Bothrops pauloensis snake venom, on Leishmania (Leishmania) amazonensis. BnSP-7 presented activity against promastigote parasite forms both in the MTT assay, with IC50 of 58.7 μg mL(-1) of toxin, and a gro...

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Bibliographic Details
Published in:	Parasitology Vol. 140; no. 7; p. 844
Main Authors:	Nunes, Débora C O, Figueira, Márcia M N R, Lopes, Daiana S, De Souza, Dayane L Naves, Izidoro, Luiz Fernando M, Ferro, Eloísa A V, Souza, Maria A, Rodrigues, Renata S, Rodrigues, Veridiana M, Yoneyama, Kelly A G
Format:	Journal Article
Language:	English
Published:	England 01-06-2013
Subjects:	Animals Bothrops - immunology Cell Differentiation - drug effects Cell Differentiation - immunology Crotalid Venoms - enzymology Crotalid Venoms - pharmacology Leishmania - immunology Leishmaniasis - drug therapy Leishmaniasis - immunology Leishmaniasis - parasitology Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - immunology Macrophages, Peritoneal - parasitology Male Mice Mice, Inbred BALB C Microscopy, Electron, Transmission Phospholipases A2 - pharmacology
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