Once-Monthly Administration of Darbepoetin Alfa for the Treatment of Patients with Chronic Heart Failure and Anemia: A Pharmacokinetic and Pharmacodynamic Investigation

In patients with chronic heart failure (CHF), anemia is associated with more severe symptoms and worse prognosis. Erythropoiesis-stimulating proteins (ESPs) increase hemoglobin and may be of therapeutic benefit. We investigated the pharmacokinetics and pharmacodynamics of the long-acting ESP, darbep...

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Bibliographic Details
Published in:	Journal of cardiovascular pharmacology Vol. 46; no. 2; pp. 155 - 161
Main Authors:	Cleland, John G. F, Sullivan, John T, Ball, Stephen, Horowitz, John D, Agoram, Balaji, Rosser, Dylan, Yates, Wayne, Tin, Lwin, Fuentealba, Paulina, Burton, Paul B. J
Format:	Journal Article
Language:	English
Published:	United States Lippincott Williams & Wilkins, Inc 01-08-2005
Subjects:	Aged Anemia - blood Anemia - complications Anemia - drug therapy Biological Availability Cardiac Output, Low - blood Cardiac Output, Low - complications Cardiac Output, Low - drug therapy Chronic Disease Cross-Over Studies Darbepoetin alfa Double-Blind Method Drug Administration Schedule Erythropoietin - administration & dosage Erythropoietin - analogs & derivatives Erythropoietin - pharmacokinetics Erythropoietin - pharmacology Erythropoietin - therapeutic use Female Hemoglobins - analysis Humans Injections, Intravenous Injections, Subcutaneous Male Middle Aged
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