Synthesis of glutamate agonists and anatagonists by a ring switching strategy

Synthesis of glutamate agonists and anatagonists by a ring switching strategy

Our ring switching strategy for synthesis of compounds with structural features consistent with activity at glutamate receptors has been modified to prepare L-alanine derivative substituted at the β-carbon atom with six-membered heteroaromatic rings. The pyrimidinone ( 11, R = R 1 = R 2 = H ) has be...

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Bibliographic Details
Published in:Tetrahedron letters Vol. 36; no. 41; pp. 7503 - 7506
Main Authors: Dinsmore, Andrew, Doyle, Paul M., Young, Douglas W.
Format: Journal Article
Language:English
Published: Elsevier Ltd 09-10-1995
Online Access:Get full text
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Summary:Our ring switching strategy for synthesis of compounds with structural features consistent with activity at glutamate receptors has been modified to prepare L-alanine derivative substituted at the β-carbon atom with six-membered heteroaromatic rings. The pyrimidinone ( 11, R = R 1 = R 2 = H ) has been shown to be a glutamate agonist and the compound ( 13) to be an antagonist. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(95)01517-5