Activation of protein kinase C by oxytocin inhibits the biological activity of the human myometrial corticotropin-releasing hormone receptor at term

The role of placental CRH in human pregnancy is currently unknown. The myometrium expresses CRH receptors that during pregnancy become coupled to adenylate cyclase. Oxytocin (OT) is one of the main regulators of uterine activity, acting via activation of the inositol triphosphate pathway. In view of...

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Bibliographic Details
Published in:	Endocrinology (Philadelphia) Vol. 140; no. 2; p. 585
Main Authors:	Grammatopoulos, D K, Hillhouse, E W
Format:	Journal Article
Language:	English
Published:	United States 01-02-1999
Subjects:	Corticotropin-Releasing Hormone - metabolism Corticotropin-Releasing Hormone - pharmacology Cyclic AMP - biosynthesis Delivery, Obstetric Drug Interactions Enzyme Activation - physiology Female Humans In Vitro Techniques Myometrium - enzymology Myometrium - metabolism Oxytocin - pharmacology Pregnancy - metabolism Protein Kinase C - metabolism Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors Receptors, Corticotropin-Releasing Hormone - drug effects Receptors, Corticotropin-Releasing Hormone - metabolism
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