Neurospecific Proteins as Transdiagnostic Markers of Affective Disorders

Neurospecific Proteins as Transdiagnostic Markers of Affective Disorders

—Mental disorders have many different pathogenesis and clinical symptoms; however, they involve general neurobiological processes that occur with damage of nervous tissue, disturbance of the blood–brain barrier, triggering of autoimmune mechanisms, neurodegenerative processes, and release of neurosp...

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Bibliographic Details
Published in:Neurochemical journal Vol. 17; no. 1; pp. 25 - 29
Main Authors: Levchuk, L. A., Bokhan, N. A., Ivanova, S. A.
Format: Journal Article
Language:English
Published: Moscow Pleiades Publishing 01-03-2023
Subjects:
Biomedical and Life Sciences
Biomedicine
Neurosciences
Review Articles
affective disorders
neurospecific proteins
damage of CNS
Online Access:Get full text
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Summary:—Mental disorders have many different pathogenesis and clinical symptoms; however, they involve general neurobiological processes that occur with damage of nervous tissue, disturbance of the blood–brain barrier, triggering of autoimmune mechanisms, neurodegenerative processes, and release of neurospecific proteins into the liquor and into the blood. We presented a review of the current literature devoted to studies of the role of neurospecific proteins in the pathogenesis of affective disorders. Glial fibrillar acidic protein (GFAP), S-100 protein, myelin basic protein (MBP), and neuron specific enolase (NSE) reflect damage to neurons, astrocytes, and oligodendrocytes in depressive disorders and they could be considered as transdiagnostic nonspecific markers of affective disorders.
ISSN:1819-7124
1819-7132
DOI:10.1134/S1819712423010117