Isolation and characterization of ICO-160 monoclonal antibodies to CD95(Fas/APO-1) antigen that mediates apoptosis

Isolation and characterization of ICO-160 monoclonal antibodies to CD95(Fas/APO-1) antigen that mediates apoptosis

Isotype IgG2a monoclonal antibodies ICO-160, detecting CD95(Fas/APO-1) antigen, were isolated and characterized. They react with 26.8±15.6% donor lymphocytes in the indirect immunofluorescence test, do not react with granulocytes, erythrocytes, and platelets, and stain part of monocytes. Monoclonal...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine Vol. 125; no. 6; pp. 594 - 596
Main Authors: Polosukhina, E. R., Zabotina, T. N., Shishkin, Yu. V., Kadagidze, Z. G., Baryshnikov, A. Yu
Format: Journal Article
Language:English
Published: New York Springer Nature B.V 01-06-1998
Subjects:
Apoptosis
Monoclonal antibodies
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Summary:Isotype IgG2a monoclonal antibodies ICO-160, detecting CD95(Fas/APO-1) antigen, were isolated and characterized. They react with 26.8±15.6% donor lymphocytes in the indirect immunofluorescence test, do not react with granulocytes, erythrocytes, and platelets, and stain part of monocytes. Monoclonal antibodies ICO-160 induce apoptosis in CD95(Fas/APO-1)-positive cells.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02445250