The genome-wide analysis of the vitamin D receptor binding sites evidences a wide range of potential therapeutic applications of vitamin D

• Published in: Medicinskij sovet Vol. 1; no. 1; pp. 12 - 21
• Main Authors: Gromova, O. A., Torshin, I. Y., Spirichev, V. B.
• Format: Journal Article
• Language: English
• Published: Remedium Group LLC 30-12-2016
• Subjects: children; epigenetics; genomic effects of vitamin d; prevention of vitamin d deficiency; геномные эффекты витамина d; дети; профилактика дефицита витамина d; эпигенетика
• ISSN: 2079-701X; 2658-5790
• DOI: 10.21518/2079-701X-2016-1-12-21

The article presents the results of the genome-wide bioinformatic analysis of the vitamin D receptor interactions with the human genome DNA. Using a biological system assay, biological roles of proteins were analyzed that are specifically associated with the impact of VDR receptor. Systematization of the biological roles of vitamin D opens broad and previously unexplored perspectives for pediatric applications of vitamin D preparations for the prevention and treatment of a wide range of diseases starting from the fetal stage and early childhood.