RISK OF RECURRENT THROMBOTIC EVENTS IN PATIENTS WITH ACUTE CORONARY SYNDROME AND HIGH PLASMA LEVELS OF D-DIMER

• Published in: Kardiovaskuli͡a︡rnai͡a︡ terapii͡a︡ i profilaktika Vol. 12; no. 4; pp. 26 - 31
• Main Authors: Panina, A. V., Puchinyan, N. F., Dovgalevskyi, Ya. P., Furman, N. V., Dolotovskaya, P. V., Malinova, L. I.
• Format: Journal Article
• Language: English
• Published: SILICEA-POLIGRAF» LLC 20-08-2013
• Subjects: atherothrombosis; coronary heart disease; d-dimer; high coronary risk
• ISSN: 1728-8800; 2619-0125
• DOI: 10.15829/1728-8800-2013-4-26-31

Aim.
To study the association of plasma D-dimer levels and the risk of thrombotic events in patients hospitalised with acute coronary syndrome (ACS).
Material and methods.
The study included 70 patients, aged 34-88 years, who were admitted to the Acute Coronary Care Unit with the ACS diagnosis.
Results.
During the follow-up period, thrombotic events were registered in 12 patients (17%). Three patients with myocardial infarction (MI) suffered recurrent MI. Nine patients were rehospitalised with the unstable angina (UA) diagnosis. All participants were divided into quartiles by the levels of D-dimer (25% percentile 136 ng/ml; median 1250 ng/ml; and 75% percentile 2930 ng/ml). High plasma levels of D-dimer (third quartile) were associated with a 1,5-fold increase in the risk of recurrent thrombotic events among ACS patients.
Conclusion.
In ACS patients, plasma D-dimer levels could be regarded as one of the additional risk factors of thrombotic events.