Description of a New Allergenic Member of the Glutathione Transferase (GST) Family from Ascaris with Omega-Class Features

Description of a New Allergenic Member of the Glutathione Transferase (GST) Family from Ascaris with Omega-Class Features

Affinity binding to Glutathione Agarose was also assessed and compared with different allergenic GSTs. rGSTO-specific IgE was determined by ELISA in 174 subjects from an A. lumbricoides endemic rural area (infection rate: 66%) and 74 asthmatic patients from Cartagena, Colombia. Positive correlation...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology Vol. 141; no. 2; p. AB176
Main Authors: Lozano, Ana M., Kong, Yoon, López, Juan F., Bustillo, Juana, Caraballo, Luis, Zakzuk, Josefina
Format: Journal Article
Language:English
Published: St. Louis Elsevier Inc 01-02-2018
Elsevier Limited
Subjects:
Ascaris
Ascaris suum
Asthma
Glutathione transferase
Rural areas
Colombia
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Summary:Affinity binding to Glutathione Agarose was also assessed and compared with different allergenic GSTs. rGSTO-specific IgE was determined by ELISA in 174 subjects from an A. lumbricoides endemic rural area (infection rate: 66%) and 74 asthmatic patients from Cartagena, Colombia. Positive correlation between specific-IgE levels to rGSTO and Asc s 13 (Spearman-rho: 0.59, p=0.01), but anti-Asc s 13 mouse pAbs did not recognize rGSTO.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.560