Advancements in Therapeutic Approaches for Proliferative Vitreoretinopathy: A Comprehensive Review

• Published in: Curēus (Palo Alto, CA) Vol. 16; no. 7; p. e65893
• Main Authors: Dhawale, Kasturi K, Tidake, Pravin
• Format: Journal Article
• Language: English
• Published: United States 31-07-2024
• Subjects: vitrectomy techniques; gene therapy; pharmacological interventions; biological therapies; proliferative vitreoretinopathy (pvr); retinal detachment
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.65893

Proliferative vitreoretinopathy (PVR) is a significant complication of retinal detachment surgery, characterized by the growth of fibrous membranes that can lead to recurrent retinal detachment and vision loss. This comprehensive review aims to summarize the latest advancements in the therapeutic approaches for PVR, encompassing historical perspectives, current surgical techniques, pharmacological interventions, biological and genetic therapies, and novel experimental treatments. Traditional surgical methods, such as vitrectomy, have been refined with advanced instrumentation and techniques to improve outcomes. Pharmacological treatments, including anti-inflammatory and anti-proliferative agents, are being explored to prevent and manage PVR. Emerging therapies, such as stem cell and gene therapy, offer promising new avenues for treatment. Despite these advancements, challenges remain in preventing recurrence and improving long-term outcomes. This review highlights the progress made and identifies areas for future research, emphasizing the importance of continued innovation to enhance patient care and reduce the burden of PVR.