Familial Cases of PENS: A Review of the Literature

Papular epidermal nevus with "skyline" basal cell layer (PENS) is a keratinocytic nevus that can occur sporadically or has a familial transmission. There are 5 families reported with PENS, in which there are 2 family members affected with each case. We present the sixth familial case, with...

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Bibliographic Details
Published in:	The American journal of dermatopathology Vol. 42; no. 8; pp. 593 - 596
Main Authors:	Santos Silva, Leandro F., Miroux-Catarino, Alexandre, Pimentel, Bernardo V., Amaro, Cristina S., Viana, Isabel F.
Format:	Journal Article
Language:	English
Published:	United States The American Journal of Dermatopathology 01-08-2020
Online Access:	Get full text
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Summary:	Papular epidermal nevus with "skyline" basal cell layer (PENS) is a keratinocytic nevus that can occur sporadically or has a familial transmission. There are 5 families reported with PENS, in which there are 2 family members affected with each case. We present the sixth familial case, with the peculiarity of being the first time in which there are 3 family members with PENS, while reviewing the other cases described until now. In addition, we present a new histopathological finding, an inflammatory lichenoid infiltrate on the upper dermis in PENS lesions. This finding could be the result of trauma to the biopsied lesion, or it may represent a new inflammatory histological variant.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Review-3 content type line 23 ObjectType-Feature-5 ObjectType-Article-4 ObjectType-Report-1
ISSN:	0193-1091 1533-0311
DOI:	10.1097/DAD.0000000000001625