An insight into deltamethrin induced apoptotic calcium, p53 and oxidative stress signalling pathways

• Published in: Toxicology and environmental health sciences Vol. 7; no. 1; pp. 25 - 34
• Main Authors: Kumar, Anoop, Sasmal, Dinakar, Sharma, Neelima
• Format: Journal Article
• Language: English
• Published: Springer Korean Society of Environmental Risk Assessment and Health Science 01-03-2015
• Subjects: Biomedical and Life Sciences; Biomedicine; Environmental Health; Mini Review; Pharmacology/Toxicology; Signalling pathways; Oxidative stress; Calcium; Deltamethrin; p53; Apoptosis
• ISSN: 2005-9752; 2233-7784
• DOI: 10.1007/s13530-015-0217-1

Deltamethrin (DLM), a type 2 synthetic pyrethroid insecticide, is widely used in home and agricultural pest control. Humans are exposed to DLM by various modes like air, water, vegetables, etc. at low concentrations. DLM has been considered as safe for humans at low concentrations. At present, its exposure has been increased due to restriction on the sale of organophosphate insecticides. Increasing use of DLM products arise the attention towards its toxicity. It has been demonstrated that DLM at high concentration cause apoptosis in the mammalian cells. However, the mechanism of DLM mediated apoptotic signaling pathways are still an open question to be explored. In the present investigation, various pathways by which DLM induces chaos to different normal cellular activities have been compiled. Possibilities of DLM induced other apoptotic signalling pathways have also been discussed which could be considered for the future studies for better understanding of its mechanism of toxicity. This review provides the detailed study of all the existing and possible apoptogenic signalling pathways induced by DLM which could be helpful for the development of various antidotes for its toxicity.