Unraveling new players in helminth pathology: extracellular vesicles from Fasciola hepatica and Dicrocoelium dendriticum exert different effects on hepatic stellate cells and hepatocytes

[Display omitted] •Fasciola hepatica extracellular vesicles (HpEVs) induce extracellular matrix secretion.•HpEVs reduce proliferation of hepatic stellate cells (HSCs)•Dicrocoelium dendriticum EVs (DdEVs) trigger a global inflammatory response in HSCs and hepatocytes.•DdEVs have a more potent anti-pr...

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Bibliographic Details
Published in:	International journal for parasitology Vol. 54; no. 12; pp. 617 - 634
Main Authors:	Sánchez-López, Christian M., González-Arce, Aránzazu, Ramírez-Toledo, Víctor, Bernal, Dolores, Marcilla, Antonio
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-10-2024
Subjects:	Animals Dicrocoeliasis - parasitology Dicrocoelium Dicrocoelium dendriticum Extracellular Vesicles - metabolism Fasciola hepatica Fasciola hepatica - physiology Fascioliasis - parasitology Fibrosis Helminth EVs Hepatic stellate cells Hepatic Stellate Cells - metabolism Hepatic Stellate Cells - parasitology Hepatocytes Hepatocytes - parasitology Humans Dicrocoelium dendriticum Fasciola hepatica Hepatic stellate cells Hepatocytes Helminth EVs Fibrosis
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