Structure of Francisella tularensis AcpA
AcpA is a respiratory burst-inhibiting acid phosphatase from the Centers for Disease Control and Prevention Category A bioterrorism agent Francisella tularensis and prototype of a superfamily of acid phosphatases and phospholipases C. We report the 1.75-Å resolution crystal structure of AcpA complex...
Saved in:
| Published in: | The Journal of biological chemistry Vol. 281; no. 40; pp. 30289 - 30298 |
|---|---|
| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier Inc
06-10-2006
American Society for Biochemistry and Molecular Biology |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | AcpA is a respiratory burst-inhibiting acid phosphatase from the Centers for Disease Control and Prevention Category A bioterrorism agent Francisella tularensis and prototype of a superfamily of acid phosphatases and phospholipases C. We report the 1.75-Å resolution crystal structure of AcpA complexed with the inhibitor orthovanadate, which is the first structure of any F. tularensis protein and the first for any member of this superfamily. The core domain is a twisted 8-stranded β-sheet flanked by three α-helices on either side, with the active site located above the carboxyl-terminal edge of the β-sheet. This architecture is unique among acid phosphatases and resembles that of alkaline phosphatase. Unexpectedly, the active site features a serine nucleophile and metal ion with octahedral coordination. Structure-based sequence analysis of the AcpA superfamily predicts that the hydroxyl nucleophile and metal center are also present in AcpA-like phospholipases C. These results imply a phospholipase C catalytic mechanism that is radically different from that of zinc metallophospholipases. |
|---|---|
| AbstractList | AcpA is a respiratory burst-inhibiting acid phosphatase from the Centers for Disease Control and Prevention Category A bioterrorism
agent Francisella tularensis and prototype of a superfamily of acid phosphatases and phospholipases C. We report the 1.75-Ã
resolution crystal structure
of AcpA complexed with the inhibitor orthovanadate, which is the first structure of any F. tularensis protein and the first for any member of this superfamily. The core domain is a twisted 8-stranded β-sheet flanked by three
α-helices on either side, with the active site located above the carboxyl-terminal edge of the β-sheet. This architecture
is unique among acid phosphatases and resembles that of alkaline phosphatase. Unexpectedly, the active site features a serine
nucleophile and metal ion with octahedral coordination. Structure-based sequence analysis of the AcpA superfamily predicts
that the hydroxyl nucleophile and metal center are also present in AcpA-like phospholipases C. These results imply a phospholipase
C catalytic mechanism that is radically different from that of zinc metallophospholipases. AcpA is a respiratory burst-inhibiting acid phosphatase from the Centers for Disease Control and Prevention Category A bioterrorism agent Francisella tularensis and prototype of a superfamily of acid phosphatases and phospholipases C. We report the 1.75-Å resolution crystal structure of AcpA complexed with the inhibitor orthovanadate, which is the first structure of any F. tularensis protein and the first for any member of this superfamily. The core domain is a twisted 8-stranded β-sheet flanked by three α-helices on either side, with the active site located above the carboxyl-terminal edge of the β-sheet. This architecture is unique among acid phosphatases and resembles that of alkaline phosphatase. Unexpectedly, the active site features a serine nucleophile and metal ion with octahedral coordination. Structure-based sequence analysis of the AcpA superfamily predicts that the hydroxyl nucleophile and metal center are also present in AcpA-like phospholipases C. These results imply a phospholipase C catalytic mechanism that is radically different from that of zinc metallophospholipases. |
| Author | Felts, Richard L. Reilly, Thomas J. Tanner, John J. |
| Author_xml | – sequence: 1 givenname: Richard L. surname: Felts fullname: Felts, Richard L. organization: Department of Chemistry, University of Missouri, Columbia, Missouri 65211 – sequence: 2 givenname: Thomas J. surname: Reilly fullname: Reilly, Thomas J. organization: Department of Veterinary Pathobiology and Veterinary Medical Diagnostic Laboratory, University of Missouri, Columbia, Missouri 65211 – sequence: 3 givenname: John J. surname: Tanner fullname: Tanner, John J. email: tannerjj@missouri.edu organization: Department of Chemistry, University of Missouri, Columbia, Missouri 65211 |
| BookMark | eNp1jz1PwzAQhi1URD9gZc7AwJLi79hjVVFAKmIAJDbLvjjUVZpUdgri32NUJCZuuRve5-6eKRp1fecRuiR4TnDFb7YO5o8SS6YJxfgETQhWrGSCvI3QBGNKSk2FGqNpSluci2tyhsZEKq25YBN0_TzEAwyH6Iu-KVbRdhCSb1tbDIfWRt-lkIoF7Bfn6LSxbfIXv32GXle3L8v7cv1097BcrEugmOKyAgWOeisbKRpFmcMgGLfOcWhcJSVlUMmKEyo0tVXtBSWq5lx4B3nShM3Q_LgXYp9S9I3Zx7Cz8csQbH6UTVY2f8oZuDoCm_C--QzRGxd62PidoYoYjg3DVOkcU8eYz89_BB9NguA78HVGYDB1H_678A1NQWa4 |
| CitedBy_id | crossref_primary_10_1074_jbc_M112_426049 crossref_primary_10_1021_acs_joc_5b02229 crossref_primary_10_1074_jbc_M109_039511 crossref_primary_10_1039_d0mt00044b crossref_primary_10_1128_IAI_02060_14 crossref_primary_10_1371_journal_ppat_1000420 crossref_primary_10_1016_j_jbiosc_2013_10_004 crossref_primary_10_2217_fmb_12_103 crossref_primary_10_1007_s10499_024_01523_2 crossref_primary_10_1128_IAI_06245_11 crossref_primary_10_1194_jlr_M012591 crossref_primary_10_1039_C9NJ02495F crossref_primary_10_3389_fmicb_2017_02592 crossref_primary_10_1007_s40828_018_0064_1 crossref_primary_10_1016_j_ccr_2021_214344 crossref_primary_10_1021_ja807418b crossref_primary_10_1016_j_jbiosc_2014_07_005 crossref_primary_10_1016_j_jinorgbio_2011_09_009 crossref_primary_10_1002_pmic_200600833 crossref_primary_10_1016_j_mgene_2019_100547 crossref_primary_10_1128_iai_00217_24 crossref_primary_10_1128_MMBR_00082_15 crossref_primary_10_1186_s12864_017_4370_6 crossref_primary_10_1016_j_bbrc_2024_149784 crossref_primary_10_1016_j_ica_2014_02_010 crossref_primary_10_3390_molecules28031289 crossref_primary_10_1016_j_ccr_2021_214192 crossref_primary_10_1128_IAI_00965_09 crossref_primary_10_1002_cbic_201402597 crossref_primary_10_1016_j_ccr_2015_03_016 crossref_primary_10_1016_j_ccr_2015_03_018 crossref_primary_10_1016_j_plipres_2012_09_001 crossref_primary_10_1016_j_pep_2012_11_005 crossref_primary_10_1107_S1744309111031551 crossref_primary_10_1038_s41598_019_46731_6 crossref_primary_10_1016_j_jmb_2009_10_009 crossref_primary_10_1002_2211_5463_12131 crossref_primary_10_1021_ic9008575 crossref_primary_10_1128_IAI_00262_08 crossref_primary_10_1099_jmm_0_2008_001826_0 crossref_primary_10_4061_2011_561841 crossref_primary_10_1128_JB_01688_07 crossref_primary_10_1016_j_ccr_2014_12_012 crossref_primary_10_3389_fchem_2019_00462 crossref_primary_10_4049_jimmunol_0903413 crossref_primary_10_1016_j_pep_2020_105663 crossref_primary_10_1111_j_1365_2958_2010_07425_x crossref_primary_10_31482_mmsl_2012_004 crossref_primary_10_1021_cg200236d crossref_primary_10_1016_j_jinorgbio_2015_04_005 crossref_primary_10_1016_j_jinorgbio_2016_04_029 crossref_primary_10_1038_s41467_023_35915_4 |
| Cites_doi | 10.1093/bioinformatics/15.4.305 10.1016/j.pep.2005.05.001 10.1146/annurev.bb.21.060192.002301 10.1128/IAI.73.12.8345-8352.2005 10.1002/prot.10286 10.1016/0968-0004(92)90246-6 10.1016/j.micpath.2004.07.002 10.1016/0968-0004(90)90179-F 10.1046/j.1365-2958.1998.00926.x 10.1111/j.1462-5822.2005.00526.x 10.1073/pnas.0307690101 10.1001/jama.285.21.2763 10.1074/jbc.271.18.10973 10.1006/jmbi.1993.1489 10.1107/S0907444999001031 10.1107/S0907444901006394 10.1038/ng1499 10.1107/S0907444903017694 10.1107/S0907444902005462 10.1107/S0907444904019158 10.1074/jbc.274.13.8351 10.1107/S0907444998003254 10.1016/S0076-6879(03)74014-2 10.1128/mr.57.2.347-366.1993 10.1107/S0108767391001071 10.1021/bi963094r 10.1107/S0021889898010504 10.1016/S0076-6879(97)76066-X 10.1002/1615-9861(200104)1:4<508::AID-PROT508>3.0.CO;2-K 10.1128/jb.172.10.5915-5923.1990 10.1007/s000180050212 10.1002/prot.1152 10.1093/nar/28.1.235 10.1016/S0162-0134(03)00176-4 10.1021/bi9821216 10.1038/nrmicro1045 10.1021/bi9714924 10.1074/jbc.M300932200 10.1016/S0022-2836(05)80360-2 10.1046/j.1365-2958.2002.03009.x 10.1046/j.1365-2958.2002.03194.x 10.1016/j.bbapap.2005.05.005 10.1016/S0955-0674(00)00240-4 10.1016/S0021-9258(18)52245-6 10.1146/annurev.bi.49.070180.004305 10.1016/S1369-5274(03)00002-X 10.1128/iai.57.5.1369-1373.1989 |
| ContentType | Journal Article |
| Copyright | 2006 © 2006 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. |
| Copyright_xml | – notice: 2006 © 2006 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. |
| DBID | 6I. AAFTH AAYXX CITATION |
| DOI | 10.1074/jbc.M606391200 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Chemistry |
| EISSN | 1083-351X |
| EndPage | 30298 |
| ExternalDocumentID | 10_1074_jbc_M606391200 281_40_30289 S0021925819339341 |
| GroupedDBID | --- -DZ -ET -~X .55 .GJ 0SF 186 18M 2WC 34G 39C 3O- 4.4 53G 5BI 5GY 5RE 5VS 6I. 79B 85S AAEDW AAFTH AAFWJ AARDX AAXUO ABDNZ ABOCM ABPPZ ABRJW ACGFO ACNCT ADBBV ADIYS ADNWM AENEX AEXQZ AFFNX AFMIJ AFOSN AFPKN AI. ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS BTFSW C1A CJ0 CS3 DIK DU5 E3Z EBS EJD F20 F5P FA8 FDB FRP GROUPED_DOAJ GX1 HH5 HYE IH2 KQ8 L7B MVM N9A OHT OK1 P-O P0W P2P R.V RHF RHI RNS ROL RPM SJN TBC TN5 TR2 UHB UKR UPT UQL VH1 VQA W8F WH7 WHG WOQ X7M XFK XSW Y6R YQT YSK YWH YZZ ZA5 ZE2 ~02 ~KM - 02 55 AAWZA ABFLS ABPTK ABUFD ABZEH ADACO ADCOW AEILP AIZTS DL DZ ET FH7 GJ H13 KM LI MYA O0- X XHC 0R~ 29J 41~ 6TJ AALRI AAYJJ AAYOK AAYXX ABFSI ABTAH ACSFO ACYGS ADVLN AITUG AKRWK BAWUL CITATION E.L J5H NHB QZG XJT YYP ZGI ZY4 |
| ID | FETCH-LOGICAL-c2020-7c8cb2ea6f65f823b0c534abb4cfb76623c767412592a7de5218d445ebc218913 |
| ISSN | 0021-9258 |
| IngestDate | Thu Nov 21 21:16:27 EST 2024 Tue Jan 05 14:52:06 EST 2021 Fri Feb 23 02:44:05 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 40 |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c2020-7c8cb2ea6f65f823b0c534abb4cfb76623c767412592a7de5218d445ebc218913 |
| OpenAccessLink | https://dx.doi.org/10.1074/jbc.M606391200 |
| PMID | 16899453 |
| PageCount | 10 |
| ParticipantIDs | crossref_primary_10_1074_jbc_M606391200 highwire_biochem_281_40_30289 elsevier_sciencedirect_doi_10_1074_jbc_M606391200 |
| ProviderPackageCode | RHF RHI |
| PublicationCentury | 2000 |
| PublicationDate | 20061006 |
| PublicationDateYYYYMMDD | 2006-10-06 |
| PublicationDate_xml | – month: 10 year: 2006 text: 20061006 day: 06 |
| PublicationDecade | 2000 |
| PublicationTitle | The Journal of biological chemistry |
| PublicationYear | 2006 |
| Publisher | Elsevier Inc American Society for Biochemistry and Molecular Biology |
| Publisher_xml | – name: Elsevier Inc – name: American Society for Biochemistry and Molecular Biology |
| References | Turro, Fu, Bradley (bib29) 2003; 40 Reilly, Felts, Henzl, Calcutt, Tanner (bib6) 2006; 45 Simonsen, Wurmser, Emr, Stenmark (bib47) 2001; 13 Kleywegt, Jones (bib22) 1999; 55 Morris, Perrakis, Lamzin (bib24) 2002; 58 Martin, Hergenrother (bib41) 1999; 38 Sjostedt (bib3) 2003; 6 Ostroff, Wretlind, Vasil (bib12) 1989; 57 Baggiolini, Wymann (bib48) 1990; 15 Weeks, Miller (bib19) 1999; 32 Hendry, Sargeson (bib39) 1990; 38 Galperin, Jedrzejas (bib32) 2001; 45 Berman, Westbrook, Feng, Gilliland, Bhat, Weissig, Shindyalov, Bourne (bib27) 2000; 28 Levitt (bib21) 2001; 57 Holtz, Stec, Kantrowitz (bib34) 1999; 274 Lohse, Denu, Santoro, Dixon (bib30) 1997; 36 Vincent, Crowder (bib8) 1995 Baron, Nano (bib42) 1998; 29 Reilly, Baron, Nano, Kuhlenschmidt (bib5) 1996; 271 Stonehouse, Cota-Gomez, Parker, Martin, Hankin, Murphy, Chen, Lim, Hackett, Vasil, Vasil (bib11) 2002; 46 Vincent, Crowder, Averill (bib37) 1992; 17 Krissinel, Henrick (bib28) 2005 Twine, Bystrom, Chen, Forsman, Golovliov, Johansson, Kelly, Lindgren, Svensson, Zingmark, Conlan, Sjostedt (bib46) 2005; 73 Van Etten, Davidson, Stevis, MacArthur, Moore (bib7) 1991; 266 Raynaud, Guilhot, Rauzier, Bordat, Pelicic, Manganelli, Smith, Gicquel, Jackson (bib13) 2002; 45 Emsley, Cowtan (bib25) 2004; 60 Ostroff, Vasil, Vasil (bib14) 1990; 172 Felts, Reilly, Tanner (bib17) 2005; 1752 Larsson, Oyston, Chain, Chu, Duffield, Fuxelius, Garcia, Halltorp, Johansson, Isherwood, Karp, Larsson, Liu, Michell, Prior, Prior, Malfatti, Sjostedt, Svensson, Thompson, Vergez, Wagg, Wren, Lindler, Andersson, Forsman, Titball (bib4) 2005; 37 Santic, Molmeret, Klose, Jones, Kwaik (bib45) 2005; 7 Lukatela, Krauss, Theis, Selmer, Gieselmann, von Figura, Saenger (bib33) 1998; 37 Knowles (bib38) 1980; 49 Altschul, Gish, Miller, Myers, Lipman (bib35) 1990; 215 Luberto, Stonehouse, Collins, Marchesini, El-Bawab, Vasil, Vasil, Hannun (bib15) 2003; 278 Winn, Murshudov, Papiz (bib26) 2003; 374 Gouet, Courcelle, Stuart, Metoz (bib49) 1999; 15 Engh, Huber (bib50) 1991; 47 Oyston, Sjostedt, Titball (bib1) 2004; 2 Titball (bib16) 1993; 57 Otwinowski, Minor (bib18) 1997; 276 Hernychova, Stulik, Halada, Macela, Kroca, Johansson, Malina (bib10) 2001; 1 Chruszcz, Laidler, Monkiewicz, Ortlund, Lebioda, Lewinski (bib40) 2003; 96 Rossolini, Schippa, Riccio, Berlutti, Macaskie, Thaller (bib9) 1998; 54 Bricogne, Vonrhein, Flensburg, Schiltz, Paciorek (bib20) 2003; 59 Lauriano, Barker, Yoon, Nano, Arulanandam, Hassett, Klose (bib43) 2004; 101 Dennis, Inglesby, Henderson, Bartlett, Ascher, Eitzen, Fine, Friedlander, Hauer, Layton, Lillibridge, McDade, Osterholm, O'Toole, Parker, Perl, Russell, Tonat (bib2) 2001; 285 Coleman (bib36) 1992; 21 Holm, Sander (bib31) 1993; 233 Brünger, Adams, Clore, DeLano, Gros, Grosse-Kunstleve, Jiang, Kuszewski, Nilges, Pannu, Read, Rice, Simonson, Warren (bib23) 1998; 54 Lai, Golovliov, Sjostedt (bib44) 2004; 37 Lovell, Davis, Arendall, de Bakker, Word, Prisant, Richardson, Richardson (bib51) 2003; 50 Otwinowski (10.1074/jbc.M606391200_bib18) 1997; 276 Turro (10.1074/jbc.M606391200_bib29) 2003; 40 Oyston (10.1074/jbc.M606391200_bib1) 2004; 2 Gouet (10.1074/jbc.M606391200_bib49) 1999; 15 Baron (10.1074/jbc.M606391200_bib42) 1998; 29 Van Etten (10.1074/jbc.M606391200_bib7) 1991; 266 Reilly (10.1074/jbc.M606391200_bib5) 1996; 271 Altschul (10.1074/jbc.M606391200_bib35) 1990; 215 Santic (10.1074/jbc.M606391200_bib45) 2005; 7 Vincent (10.1074/jbc.M606391200_bib8) 1995 Knowles (10.1074/jbc.M606391200_bib38) 1980; 49 Simonsen (10.1074/jbc.M606391200_bib47) 2001; 13 Sjostedt (10.1074/jbc.M606391200_bib3) 2003; 6 Larsson (10.1074/jbc.M606391200_bib4) 2005; 37 Titball (10.1074/jbc.M606391200_bib16) 1993; 57 Chruszcz (10.1074/jbc.M606391200_bib40) 2003; 96 Luberto (10.1074/jbc.M606391200_bib15) 2003; 278 Bricogne (10.1074/jbc.M606391200_bib20) 2003; 59 Kleywegt (10.1074/jbc.M606391200_bib22) 1999; 55 Lai (10.1074/jbc.M606391200_bib44) 2004; 37 Berman (10.1074/jbc.M606391200_bib27) 2000; 28 Winn (10.1074/jbc.M606391200_bib26) 2003; 374 Krissinel (10.1074/jbc.M606391200_bib28) 2005 Twine (10.1074/jbc.M606391200_bib46) 2005; 73 Stonehouse (10.1074/jbc.M606391200_bib11) 2002; 46 Lauriano (10.1074/jbc.M606391200_bib43) 2004; 101 Hernychova (10.1074/jbc.M606391200_bib10) 2001; 1 Weeks (10.1074/jbc.M606391200_bib19) 1999; 32 Brünger (10.1074/jbc.M606391200_bib23) 1998; 54 Ostroff (10.1074/jbc.M606391200_bib12) 1989; 57 Rossolini (10.1074/jbc.M606391200_bib9) 1998; 54 Lohse (10.1074/jbc.M606391200_bib30) 1997; 36 Raynaud (10.1074/jbc.M606391200_bib13) 2002; 45 Engh (10.1074/jbc.M606391200_bib50) 1991; 47 Emsley (10.1074/jbc.M606391200_bib25) 2004; 60 Lovell (10.1074/jbc.M606391200_bib51) 2003; 50 Galperin (10.1074/jbc.M606391200_bib32) 2001; 45 Baggiolini (10.1074/jbc.M606391200_bib48) 1990; 15 Hendry (10.1074/jbc.M606391200_bib39) 1990; 38 Holtz (10.1074/jbc.M606391200_bib34) 1999; 274 Ostroff (10.1074/jbc.M606391200_bib14) 1990; 172 Morris (10.1074/jbc.M606391200_bib24) 2002; 58 Levitt (10.1074/jbc.M606391200_bib21) 2001; 57 Holm (10.1074/jbc.M606391200_bib31) 1993; 233 Coleman (10.1074/jbc.M606391200_bib36) 1992; 21 Dennis (10.1074/jbc.M606391200_bib2) 2001; 285 Lukatela (10.1074/jbc.M606391200_bib33) 1998; 37 Vincent (10.1074/jbc.M606391200_bib37) 1992; 17 Martin (10.1074/jbc.M606391200_bib41) 1999; 38 Felts (10.1074/jbc.M606391200_bib17) 2005; 1752 Reilly (10.1074/jbc.M606391200_bib6) 2006; 45 |
| References_xml | – volume: 45 start-page: 203 year: 2002 end-page: 217 ident: bib13 publication-title: Mol. Microbiol. contributor: fullname: Jackson – volume: 38 start-page: 4403 year: 1999 end-page: 4408 ident: bib41 publication-title: Biochemistry contributor: fullname: Hergenrother – start-page: 163 year: 2005 end-page: 174 ident: bib28 publication-title: Computational Life Sciences: First International Symposium contributor: fullname: Henrick – volume: 49 start-page: 877 year: 1980 end-page: 919 ident: bib38 publication-title: Annu. Rev. Biochem. contributor: fullname: Knowles – volume: 7 start-page: 969 year: 2005 end-page: 979 ident: bib45 publication-title: Cell. Microbiol. contributor: fullname: Kwaik – volume: 57 start-page: 347 year: 1993 end-page: 366 ident: bib16 publication-title: Microbiol. Rev. contributor: fullname: Titball – volume: 54 start-page: 833 year: 1998 end-page: 850 ident: bib9 publication-title: Cell. Mol. Life Sci. contributor: fullname: Thaller – volume: 57 start-page: 1369 year: 1989 end-page: 1373 ident: bib12 publication-title: Infect. Immun. contributor: fullname: Vasil – volume: 285 start-page: 2763 year: 2001 end-page: 2773 ident: bib2 publication-title: J. Am. Med. Assoc. contributor: fullname: Tonat – volume: 96 start-page: 386 year: 2003 end-page: 392 ident: bib40 publication-title: J. Inorg. Biochem. contributor: fullname: Lewinski – volume: 37 start-page: 153 year: 2005 end-page: 159 ident: bib4 publication-title: Nat. Genet. contributor: fullname: Titball – year: 1995 ident: bib8 publication-title: Phosphatases in Cell Metabolism and Signal Transduction: Structure, Function, and Mechanism of Action contributor: fullname: Crowder – volume: 37 start-page: 225 year: 2004 end-page: 230 ident: bib44 publication-title: Microb. Pathog. contributor: fullname: Sjostedt – volume: 55 start-page: 941 year: 1999 end-page: 944 ident: bib22 publication-title: Acta Crystallogr. Sect. D Biol. Crystallogr. contributor: fullname: Jones – volume: 38 start-page: 201 year: 1990 end-page: 258 ident: bib39 publication-title: Progress in Inorganic Chemistry: Bioinorganic Chemistry contributor: fullname: Sargeson – volume: 15 start-page: 305 year: 1999 end-page: 308 ident: bib49 publication-title: Bioinformatics contributor: fullname: Metoz – volume: 59 start-page: 2023 year: 2003 end-page: 2030 ident: bib20 publication-title: Acta Crystallogr. Sect. D Biol. Crystallogr. contributor: fullname: Paciorek – volume: 101 start-page: 4246 year: 2004 end-page: 4249 ident: bib43 publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Klose – volume: 17 start-page: 105 year: 1992 end-page: 110 ident: bib37 publication-title: Trends Biochem. Sci. contributor: fullname: Averill – volume: 58 start-page: 968 year: 2002 end-page: 975 ident: bib24 publication-title: Acta Crystallogr. Sect. D Biol. Crystallogr. contributor: fullname: Lamzin – volume: 50 start-page: 437 year: 2003 end-page: 450 ident: bib51 publication-title: Proteins contributor: fullname: Richardson – volume: 57 start-page: 1013 year: 2001 end-page: 1019 ident: bib21 publication-title: Acta Crystallogr. Sect. D Biol. Crystallogr. contributor: fullname: Levitt – volume: 36 start-page: 4568 year: 1997 end-page: 4575 ident: bib30 publication-title: Biochemistry contributor: fullname: Dixon – volume: 46 start-page: 661 year: 2002 end-page: 676 ident: bib11 publication-title: Mol. Microbiol. contributor: fullname: Vasil – volume: 15 start-page: 69 year: 1990 end-page: 72 ident: bib48 publication-title: Trends Biochem. Sci. contributor: fullname: Wymann – volume: 45 start-page: 318 year: 2001 end-page: 324 ident: bib32 publication-title: Proteins contributor: fullname: Jedrzejas – volume: 1 start-page: 508 year: 2001 end-page: 515 ident: bib10 publication-title: Proteomics contributor: fullname: Malina – volume: 278 start-page: 32733 year: 2003 end-page: 32743 ident: bib15 publication-title: J. Biol. Chem. contributor: fullname: Hannun – volume: 266 start-page: 2313 year: 1991 end-page: 2319 ident: bib7 publication-title: J. Biol. Chem. contributor: fullname: Moore – volume: 274 start-page: 8351 year: 1999 end-page: 8354 ident: bib34 publication-title: J. Biol. Chem. contributor: fullname: Kantrowitz – volume: 374 start-page: 300 year: 2003 end-page: 321 ident: bib26 publication-title: Methods Enzymol. contributor: fullname: Papiz – volume: 60 start-page: 2126 year: 2004 end-page: 2132 ident: bib25 publication-title: Acta Crystallogr. Sect. D Biol. Crystallogr. contributor: fullname: Cowtan – volume: 172 start-page: 5915 year: 1990 end-page: 5923 ident: bib14 publication-title: J. Bacteriol. contributor: fullname: Vasil – volume: 54 start-page: 905 year: 1998 end-page: 921 ident: bib23 publication-title: Acta Crystallogr. Sect. D Biol. Crystallogr. contributor: fullname: Warren – volume: 233 start-page: 123 year: 1993 end-page: 138 ident: bib31 publication-title: J. Mol. Biol. contributor: fullname: Sander – volume: 47 start-page: 392 year: 1991 end-page: 400 ident: bib50 publication-title: Acta Crystallogr. Sect. A contributor: fullname: Huber – volume: 6 start-page: 66 year: 2003 end-page: 71 ident: bib3 publication-title: Curr. Opin. Microbiol. contributor: fullname: Sjostedt – volume: 21 start-page: 441483 year: 1992 ident: bib36 publication-title: Annu. Rev. Biophys. Biomol. Struct. contributor: fullname: Coleman – volume: 271 start-page: 10973 year: 1996 end-page: 10983 ident: bib5 publication-title: J. Biol. Chem. contributor: fullname: Kuhlenschmidt – volume: 276 start-page: 307 year: 1997 end-page: 326 ident: bib18 publication-title: Methods Enzymol. contributor: fullname: Minor – volume: 13 start-page: 485 year: 2001 end-page: 492 ident: bib47 publication-title: Curr. Opin. Cell Biol. contributor: fullname: Stenmark – volume: 2 start-page: 967 year: 2004 end-page: 978 ident: bib1 publication-title: Nat. Rev. Microbiol. contributor: fullname: Titball – volume: 40 start-page: 323 year: 2003 end-page: 353 ident: bib29 publication-title: Metal Ions in Biological Systems contributor: fullname: Bradley – volume: 73 start-page: 8345 year: 2005 end-page: 8352 ident: bib46 publication-title: Infect. Immun. contributor: fullname: Sjostedt – volume: 37 start-page: 3654 year: 1998 end-page: 3664 ident: bib33 publication-title: Biochemistry contributor: fullname: Saenger – volume: 215 start-page: 403 year: 1990 end-page: 410 ident: bib35 publication-title: J. Mol. Biol. contributor: fullname: Lipman – volume: 45 start-page: 132 year: 2006 end-page: 141 ident: bib6 publication-title: Protein Expr. Purif. contributor: fullname: Tanner – volume: 32 start-page: 120 year: 1999 end-page: 124 ident: bib19 publication-title: J. Appl. Crystallogr. contributor: fullname: Miller – volume: 28 start-page: 235 year: 2000 end-page: 242 ident: bib27 publication-title: Nucleic Acids Res. contributor: fullname: Bourne – volume: 29 start-page: 247 year: 1998 end-page: 259 ident: bib42 publication-title: Mol. Microbiol. contributor: fullname: Nano – volume: 1752 start-page: 107 year: 2005 end-page: 110 ident: bib17 publication-title: Biochim. Biophys. Acta contributor: fullname: Tanner – volume: 15 start-page: 305 year: 1999 ident: 10.1074/jbc.M606391200_bib49 publication-title: Bioinformatics doi: 10.1093/bioinformatics/15.4.305 contributor: fullname: Gouet – volume: 45 start-page: 132 year: 2006 ident: 10.1074/jbc.M606391200_bib6 publication-title: Protein Expr. Purif. doi: 10.1016/j.pep.2005.05.001 contributor: fullname: Reilly – volume: 21 start-page: 441483 year: 1992 ident: 10.1074/jbc.M606391200_bib36 publication-title: Annu. Rev. Biophys. Biomol. Struct. doi: 10.1146/annurev.bb.21.060192.002301 contributor: fullname: Coleman – volume: 73 start-page: 8345 year: 2005 ident: 10.1074/jbc.M606391200_bib46 publication-title: Infect. Immun. doi: 10.1128/IAI.73.12.8345-8352.2005 contributor: fullname: Twine – volume: 50 start-page: 437 year: 2003 ident: 10.1074/jbc.M606391200_bib51 publication-title: Proteins doi: 10.1002/prot.10286 contributor: fullname: Lovell – volume: 17 start-page: 105 year: 1992 ident: 10.1074/jbc.M606391200_bib37 publication-title: Trends Biochem. Sci. doi: 10.1016/0968-0004(92)90246-6 contributor: fullname: Vincent – volume: 37 start-page: 225 year: 2004 ident: 10.1074/jbc.M606391200_bib44 publication-title: Microb. Pathog. doi: 10.1016/j.micpath.2004.07.002 contributor: fullname: Lai – volume: 15 start-page: 69 year: 1990 ident: 10.1074/jbc.M606391200_bib48 publication-title: Trends Biochem. Sci. doi: 10.1016/0968-0004(90)90179-F contributor: fullname: Baggiolini – volume: 29 start-page: 247 year: 1998 ident: 10.1074/jbc.M606391200_bib42 publication-title: Mol. Microbiol. doi: 10.1046/j.1365-2958.1998.00926.x contributor: fullname: Baron – volume: 7 start-page: 969 year: 2005 ident: 10.1074/jbc.M606391200_bib45 publication-title: Cell. Microbiol. doi: 10.1111/j.1462-5822.2005.00526.x contributor: fullname: Santic – volume: 101 start-page: 4246 year: 2004 ident: 10.1074/jbc.M606391200_bib43 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0307690101 contributor: fullname: Lauriano – volume: 285 start-page: 2763 year: 2001 ident: 10.1074/jbc.M606391200_bib2 publication-title: J. Am. Med. Assoc. doi: 10.1001/jama.285.21.2763 contributor: fullname: Dennis – volume: 271 start-page: 10973 year: 1996 ident: 10.1074/jbc.M606391200_bib5 publication-title: J. Biol. Chem. doi: 10.1074/jbc.271.18.10973 contributor: fullname: Reilly – volume: 233 start-page: 123 year: 1993 ident: 10.1074/jbc.M606391200_bib31 publication-title: J. Mol. Biol. doi: 10.1006/jmbi.1993.1489 contributor: fullname: Holm – volume: 55 start-page: 941 year: 1999 ident: 10.1074/jbc.M606391200_bib22 publication-title: Acta Crystallogr. Sect. D Biol. Crystallogr. doi: 10.1107/S0907444999001031 contributor: fullname: Kleywegt – volume: 57 start-page: 1013 year: 2001 ident: 10.1074/jbc.M606391200_bib21 publication-title: Acta Crystallogr. Sect. D Biol. Crystallogr. doi: 10.1107/S0907444901006394 contributor: fullname: Levitt – volume: 37 start-page: 153 year: 2005 ident: 10.1074/jbc.M606391200_bib4 publication-title: Nat. Genet. doi: 10.1038/ng1499 contributor: fullname: Larsson – volume: 59 start-page: 2023 year: 2003 ident: 10.1074/jbc.M606391200_bib20 publication-title: Acta Crystallogr. Sect. D Biol. Crystallogr. doi: 10.1107/S0907444903017694 contributor: fullname: Bricogne – volume: 58 start-page: 968 year: 2002 ident: 10.1074/jbc.M606391200_bib24 publication-title: Acta Crystallogr. Sect. D Biol. Crystallogr. doi: 10.1107/S0907444902005462 contributor: fullname: Morris – volume: 60 start-page: 2126 year: 2004 ident: 10.1074/jbc.M606391200_bib25 publication-title: Acta Crystallogr. Sect. D Biol. Crystallogr. doi: 10.1107/S0907444904019158 contributor: fullname: Emsley – volume: 274 start-page: 8351 year: 1999 ident: 10.1074/jbc.M606391200_bib34 publication-title: J. Biol. Chem. doi: 10.1074/jbc.274.13.8351 contributor: fullname: Holtz – year: 1995 ident: 10.1074/jbc.M606391200_bib8 contributor: fullname: Vincent – volume: 54 start-page: 905 year: 1998 ident: 10.1074/jbc.M606391200_bib23 publication-title: Acta Crystallogr. Sect. D Biol. Crystallogr. doi: 10.1107/S0907444998003254 contributor: fullname: Brünger – volume: 374 start-page: 300 year: 2003 ident: 10.1074/jbc.M606391200_bib26 publication-title: Methods Enzymol. doi: 10.1016/S0076-6879(03)74014-2 contributor: fullname: Winn – volume: 57 start-page: 347 year: 1993 ident: 10.1074/jbc.M606391200_bib16 publication-title: Microbiol. Rev. doi: 10.1128/mr.57.2.347-366.1993 contributor: fullname: Titball – volume: 47 start-page: 392 year: 1991 ident: 10.1074/jbc.M606391200_bib50 publication-title: Acta Crystallogr. Sect. A doi: 10.1107/S0108767391001071 contributor: fullname: Engh – volume: 36 start-page: 4568 year: 1997 ident: 10.1074/jbc.M606391200_bib30 publication-title: Biochemistry doi: 10.1021/bi963094r contributor: fullname: Lohse – volume: 32 start-page: 120 year: 1999 ident: 10.1074/jbc.M606391200_bib19 publication-title: J. Appl. Crystallogr. doi: 10.1107/S0021889898010504 contributor: fullname: Weeks – volume: 276 start-page: 307 year: 1997 ident: 10.1074/jbc.M606391200_bib18 publication-title: Methods Enzymol. doi: 10.1016/S0076-6879(97)76066-X contributor: fullname: Otwinowski – volume: 1 start-page: 508 year: 2001 ident: 10.1074/jbc.M606391200_bib10 publication-title: Proteomics doi: 10.1002/1615-9861(200104)1:4<508::AID-PROT508>3.0.CO;2-K contributor: fullname: Hernychova – start-page: 163 year: 2005 ident: 10.1074/jbc.M606391200_bib28 contributor: fullname: Krissinel – volume: 172 start-page: 5915 year: 1990 ident: 10.1074/jbc.M606391200_bib14 publication-title: J. Bacteriol. doi: 10.1128/jb.172.10.5915-5923.1990 contributor: fullname: Ostroff – volume: 54 start-page: 833 year: 1998 ident: 10.1074/jbc.M606391200_bib9 publication-title: Cell. Mol. Life Sci. doi: 10.1007/s000180050212 contributor: fullname: Rossolini – volume: 45 start-page: 318 year: 2001 ident: 10.1074/jbc.M606391200_bib32 publication-title: Proteins doi: 10.1002/prot.1152 contributor: fullname: Galperin – volume: 28 start-page: 235 year: 2000 ident: 10.1074/jbc.M606391200_bib27 publication-title: Nucleic Acids Res. doi: 10.1093/nar/28.1.235 contributor: fullname: Berman – volume: 96 start-page: 386 year: 2003 ident: 10.1074/jbc.M606391200_bib40 publication-title: J. Inorg. Biochem. doi: 10.1016/S0162-0134(03)00176-4 contributor: fullname: Chruszcz – volume: 38 start-page: 4403 year: 1999 ident: 10.1074/jbc.M606391200_bib41 publication-title: Biochemistry doi: 10.1021/bi9821216 contributor: fullname: Martin – volume: 2 start-page: 967 year: 2004 ident: 10.1074/jbc.M606391200_bib1 publication-title: Nat. Rev. Microbiol. doi: 10.1038/nrmicro1045 contributor: fullname: Oyston – volume: 37 start-page: 3654 year: 1998 ident: 10.1074/jbc.M606391200_bib33 publication-title: Biochemistry doi: 10.1021/bi9714924 contributor: fullname: Lukatela – volume: 278 start-page: 32733 year: 2003 ident: 10.1074/jbc.M606391200_bib15 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M300932200 contributor: fullname: Luberto – volume: 40 start-page: 323 year: 2003 ident: 10.1074/jbc.M606391200_bib29 contributor: fullname: Turro – volume: 215 start-page: 403 year: 1990 ident: 10.1074/jbc.M606391200_bib35 publication-title: J. Mol. Biol. doi: 10.1016/S0022-2836(05)80360-2 contributor: fullname: Altschul – volume: 45 start-page: 203 year: 2002 ident: 10.1074/jbc.M606391200_bib13 publication-title: Mol. Microbiol. doi: 10.1046/j.1365-2958.2002.03009.x contributor: fullname: Raynaud – volume: 46 start-page: 661 year: 2002 ident: 10.1074/jbc.M606391200_bib11 publication-title: Mol. Microbiol. doi: 10.1046/j.1365-2958.2002.03194.x contributor: fullname: Stonehouse – volume: 1752 start-page: 107 year: 2005 ident: 10.1074/jbc.M606391200_bib17 publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbapap.2005.05.005 contributor: fullname: Felts – volume: 38 start-page: 201 year: 1990 ident: 10.1074/jbc.M606391200_bib39 contributor: fullname: Hendry – volume: 13 start-page: 485 year: 2001 ident: 10.1074/jbc.M606391200_bib47 publication-title: Curr. Opin. Cell Biol. doi: 10.1016/S0955-0674(00)00240-4 contributor: fullname: Simonsen – volume: 266 start-page: 2313 year: 1991 ident: 10.1074/jbc.M606391200_bib7 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)52245-6 contributor: fullname: Van Etten – volume: 49 start-page: 877 year: 1980 ident: 10.1074/jbc.M606391200_bib38 publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev.bi.49.070180.004305 contributor: fullname: Knowles – volume: 6 start-page: 66 year: 2003 ident: 10.1074/jbc.M606391200_bib3 publication-title: Curr. Opin. Microbiol. doi: 10.1016/S1369-5274(03)00002-X contributor: fullname: Sjostedt – volume: 57 start-page: 1369 year: 1989 ident: 10.1074/jbc.M606391200_bib12 publication-title: Infect. Immun. doi: 10.1128/iai.57.5.1369-1373.1989 contributor: fullname: Ostroff |
| SSID | ssj0000491 |
| Score | 1.8667916 |
| Snippet | AcpA is a respiratory burst-inhibiting acid phosphatase from the Centers for Disease Control and Prevention Category A bioterrorism agent Francisella... AcpA is a respiratory burst-inhibiting acid phosphatase from the Centers for Disease Control and Prevention Category A bioterrorism agent Francisella... |
| SourceID | crossref highwire elsevier |
| SourceType | Aggregation Database Publisher |
| StartPage | 30289 |
| Title | Structure of Francisella tularensis AcpA |
| URI | https://dx.doi.org/10.1074/jbc.M606391200 http://www.jbc.org/content/281/40/30289.abstract |
| Volume | 281 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LS8NAEF58HPQiPrG-yEFUKKlNdvM6Fq2IqBcreFt2NxsQtBVaD_57Z7K72SgKKngJIaFpOvN19mNn5htCDqlm2GFdhTqJy5DljIaCCRVKbIMsYUWWFPudL--y24f8fMiGviDTX_tXT8M18DV2zv7C281D4QKcg8_hCF6H44_8flcLwmJaAGigG5sBvu7OsOAUy9Wn3YF6GbRZqe8Pq5mpEWYy0iFuHpynjE-zaasjv3vda3I2-tHOrTZVR92r5tZIuAlfdaWOveE3GzBVnvodMNcF86FI05R5xEaCvadNIAVqh10CD-1IG5vpLBZSRqbJBk6KGc_WKkxRGv7LEA-cB0O8VL2bFPlVZKROP8tmYxY6wpcChkoLitoGizEEI-p2dNxqzexURfsbnLBnxk4_fsd3xKXRlW7xktEqWbFuCwYGCWtkTo_XycZgLGaT57fgKKhLfOvcyTpZOnPu3CAnDVCCSRW0gBJ4oAQIlE1yfzEcnV2GdmxGqGLcDMhUrmSsRVqlSZXHVPZVQpmQkqlKZinwXYUKTsBsi1hkJfxJo7xkLNFSwVkR0S2yMJ6M9TYJkkjkBXDIIhUFo7ovKWOV6Oe6hNit06xDjp1N-ItRR-F1VUPGOFiPe-t1SORMxi23M5yNg1-__cy-sy0H5CPiOUCIsz6v4bLzh2fukmWP6z2yAKbW-2R-Wr4e1Lh4B23AcdY |
| link.rule.ids | 315,782,786,27933,27934 |
| linkProvider | National Library of Medicine |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Structure+of+Francisella+tularensis+AcpA&rft.jtitle=The+Journal+of+biological+chemistry&rft.au=Felts%2C+Richard+L.&rft.au=Reilly%2C+Thomas+J.&rft.au=Tanner%2C+John+J.&rft.date=2006-10-06&rft.pub=Elsevier+Inc&rft.issn=0021-9258&rft.eissn=1083-351X&rft.volume=281&rft.issue=40&rft.spage=30289&rft.epage=30298&rft_id=info:doi/10.1074%2Fjbc.M606391200&rft.externalDocID=S0021925819339341 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9258&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9258&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9258&client=summon |