A pH‐Responsive Cluster Metal–Organic Framework Nanoparticle for Enhanced Tumor Accumulation and Antitumor Effect (Adv. Mater. 42/2022)

Tumor Therapy A pH‐responsive cluster metal–organic framework nanoparticle is developed by Wenguo Cui, Baiyong Shen, Hélder A. Santos, and co‐workers in article number 2203915, based on acid‐induced conversion from hydrophilicity to hydrophobicity, leading to aggregated nanoparticles. These nanopart...

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Published in:	Advanced materials (Weinheim) Vol. 34; no. 42
Main Authors:	Cheng, Ruoyu, Jiang, Lingxi, Gao, Han, Liu, Zehua, Mäkilä, Ermei, Wang, Shiqi, Saiding, Qimanguli, Xiang, Lei, Tang, Xiaomei, Shi, Minmin, Liu, Jia, Pang, Libin, Salonen, Jarno, Hirvonen, Jouni, Zhang, Hongbo, Cui, Wenguo, Shen, Baiyong, Santos, Hélder A.
Format:	Journal Article
Language:	English
Published:	Weinheim Wiley Subscription Services, Inc 01-10-2022
Subjects:	Anticancer properties cancer Clusters Hydrophobicity Materials science Metal-organic frameworks Nanoparticles pH‐responsive targeting targeting
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Abstract	Tumor Therapy A pH‐responsive cluster metal–organic framework nanoparticle is developed by Wenguo Cui, Baiyong Shen, Hélder A. Santos, and co‐workers in article number 2203915, based on acid‐induced conversion from hydrophilicity to hydrophobicity, leading to aggregated nanoparticles. These nanoparticles inhibit tumor growth and reactivate the tumor microenvironment in both pancreatic and breast cancer models.
AbstractList	Tumor Therapy A pH‐responsive cluster metal–organic framework nanoparticle is developed by Wenguo Cui, Baiyong Shen, Hélder A. Santos, and co‐workers in article number 2203915, based on acid‐induced conversion from hydrophilicity to hydrophobicity, leading to aggregated nanoparticles. These nanoparticles inhibit tumor growth and reactivate the tumor microenvironment in both pancreatic and breast cancer models. Tumor TherapyA pH‐responsive cluster metal–organic framework nanoparticle is developed by Wenguo Cui, Baiyong Shen, Hélder A. Santos, and co‐workers in article number 2203915, based on acid‐induced conversion from hydrophilicity to hydrophobicity, leading to aggregated nanoparticles. These nanoparticles inhibit tumor growth and reactivate the tumor microenvironment in both pancreatic and breast cancer models.
Author	Shi, Minmin Liu, Zehua Salonen, Jarno Wang, Shiqi Santos, Hélder A. Zhang, Hongbo Cheng, Ruoyu Mäkilä, Ermei Jiang, Lingxi Pang, Libin Gao, Han Saiding, Qimanguli Tang, Xiaomei Liu, Jia Hirvonen, Jouni Cui, Wenguo Xiang, Lei Shen, Baiyong
Author_xml	– sequence: 1 givenname: Ruoyu surname: Cheng fullname: Cheng, Ruoyu organization: University of Helsinki – sequence: 2 givenname: Lingxi surname: Jiang fullname: Jiang, Lingxi organization: Shanghai Jiaotong University School of Medicine – sequence: 3 givenname: Han surname: Gao fullname: Gao, Han organization: University of Helsinki – sequence: 4 givenname: Zehua surname: Liu fullname: Liu, Zehua organization: University of Helsinki – sequence: 5 givenname: Ermei surname: Mäkilä fullname: Mäkilä, Ermei organization: University of Turku – sequence: 6 givenname: Shiqi surname: Wang fullname: Wang, Shiqi organization: University of Helsinki – sequence: 7 givenname: Qimanguli surname: Saiding fullname: Saiding, Qimanguli organization: Shanghai Jiao Tong University School of Medicine – sequence: 8 givenname: Lei surname: Xiang fullname: Xiang, Lei organization: Shanghai Jiao Tong University School of Medicine – sequence: 9 givenname: Xiaomei surname: Tang fullname: Tang, Xiaomei organization: Shanghai Jiaotong University School of Medicine – sequence: 10 givenname: Minmin surname: Shi fullname: Shi, Minmin organization: Shanghai Jiaotong University School of Medicine – sequence: 11 givenname: Jia surname: Liu fullname: Liu, Jia organization: Shanghai Jiaotong University School of Medicine – sequence: 12 givenname: Libin surname: Pang fullname: Pang, Libin organization: Shanghai Jiao Tong University School of Medicine – sequence: 13 givenname: Jarno surname: Salonen fullname: Salonen, Jarno organization: University of Turku – sequence: 14 givenname: Jouni surname: Hirvonen fullname: Hirvonen, Jouni organization: University of Helsinki – sequence: 15 givenname: Hongbo surname: Zhang fullname: Zhang, Hongbo organization: University of Turku and Åbo Akademi University – sequence: 16 givenname: Wenguo surname: Cui fullname: Cui, Wenguo organization: Shanghai Jiao Tong University School of Medicine – sequence: 17 givenname: Baiyong surname: Shen fullname: Shen, Baiyong organization: Shanghai Jiaotong University School of Medicine – sequence: 18 givenname: Hélder A. surname: Santos fullname: Santos, Hélder A. organization: University of Helsinki
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Snippet	Tumor Therapy A pH‐responsive cluster metal–organic framework nanoparticle is developed by Wenguo Cui, Baiyong Shen, Hélder A. Santos, and co‐workers in... Tumor TherapyA pH‐responsive cluster metal–organic framework nanoparticle is developed by Wenguo Cui, Baiyong Shen, Hélder A. Santos, and co‐workers in article...
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SubjectTerms	Anticancer properties cancer Clusters Hydrophobicity Materials science Metal-organic frameworks Nanoparticles pH‐responsive targeting targeting
Title	A pH‐Responsive Cluster Metal–Organic Framework Nanoparticle for Enhanced Tumor Accumulation and Antitumor Effect (Adv. Mater. 42/2022)
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