The synthesis and antitumor activity of novel 1-alkyl-3-phenyland 3-alkyl-1-phenylimidazothiazolotriazines

• Published in: Chemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 60; no. 3-4; pp. 196 - 204
• Main Authors: Izmest’ev, Alexei N., Isakov, Sergey S., Kravchenko, Angelina N., Gazieva, Galina A.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-04-2024; Springer Nature B.V
• Subjects: Cancer; Chemistry; Chemistry and Materials Science; Leukemia; Organic Chemistry; Pharmacy; oxindoles; isatins; thiazolidin-4-ones; aldol condensation; antiproliferative activity
• ISSN: 0009-3122; 1573-8353
• DOI: 10.1007/s10593-024-03318-y

Two groups of isomeric imidazothiazolo[1,2,4]triazines and their oxindolylidene derivatives were obtained from 1-alkyl-3-aryl-4,5-dihydroxyimidazolidin-2-(thi)ones. One of the synthesized imidazo[4,5-
e
]thiazolo[2,3-
c
][1,2,4]triazine derivatives showed high cytostatic activity at a concentration of 10 μmol/l against four lines of tumor cells: HL-60(TB) (leukemia, –16.1% growth rate), SF-539 (CNS cancer, –2.6% growth rate), MDA-MB-435 (melanoma, –21.2% growth rate), and RXF 393 (kidney cancer, –6.1 % growth rate).