TRIM65 regulates innate immune signaling by enhancing K6-linked ubiquitination of IRF3 and its chromatin recruitment

Viral infection triggers a rapid and effective cellular response primarily mediated by interferon β (IFNβ), which induces an antiviral state through complex signaling cascades. To maintain a robust antiviral response while preventing excessive activation, the induction of IFNβ and downstream signali...

Full description

Bibliographic Details

Published in:	Cell reports (Cambridge) Vol. 43; no. 12; p. 114960
Main Authors:	Fonseca, Danae, Pisanelli, Giuseppe, Seoane, Rocío, Miorin, Lisa, García-Sastre, Adolfo
Format:	Journal Article
Language:	English
Published:	Elsevier Inc 01-12-2024 Elsevier
Subjects:	chromatin CP: Immunology IFNβ promoter innate immunity IRF3 K6-linked ubiquitination TRIM65 CP: Immunology IRF3 innate immunity K6-linked ubiquitination IFNβ promoter chromatin TRIM65
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!