Neurological Aspects of Systemic Lupus Erythematosus in Individuals with Late Ontogenetic Debut

• Published in: Advances in gerontology Vol. 12; no. 4; pp. 396 - 406
• Main Authors: Odin, V. I., Yurkina, E. A., Yurkin, A. K., Toporkov, M. M., Shvartsman, G. I., Pervova, E. M.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01-12-2022; Springer Nature B.V
• Subjects: Age groups; Antibodies; Antigens; Autoimmune diseases; Brain; Geriatrics/Gerontology; Hypotheses; Lupus; Lymphocytes; Medical research; Medicine; Medicine & Public Health; Nervous system; Neurological disorders; Pathogenesis; Pathology; Population; Rheumatic diseases; autoimmune diseases; systemic lupus erythematosus; diagnostics; late debut; myelitis; ontogenesis; cramps; cognitive dysfunction; clinical pattern; psychosis
• ISSN: 2079-0570; 2079-0589
• DOI: 10.1134/S2079057022040129

The review presents the analysis of publications about the peculiarities of the manifestation of systemic lupus erythematosus (SLE) in individuals of older age groups. The probable reasons and mechanisms of the development of neurological manifestations of the disease are reflected in the work. The clinical pattern in elderly patients is described in detail and the peculiarities of immune indices are noted. This article considers different variants of nervous-system damage with SLE that differ in a wide spectrum of clinical manifestations. Neurobehavioral disorders with SLE are one of the least studied aspects and can be both a manifestation of the main disease (including those coinciding with the processes of immunoaging) and adverse events during the treatment. At the same time, knowledge of the peculiarities of neurological manifestations with SLE with its onset in late ontogenesis in comparison with the data of laboratory and instrumental methods of examination allow early diagnosis to be carried out and adequate therapy for elderly patients to be established in a timely manner.