Effects of milk from goat fed Crotalaria spectabilis seeds on growing rats

Seeds of Crotalaria spectabilis, containing the pyrrolizidine alkaloid (PA) monocrotaline (MCT), were fed to a lactating dairy goat. Milk from this goat was fed to rats for 8 weeks to determine whether MCT or its toxic metabolites are transferred into the goat’s milk. Rats from the experimental grou...

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Bibliographic Details
Published in:	Brazilian journal of veterinary research and animal science Vol. 36; no. 2
Main Authors:	MEDEIROS, Rosane Maria Trindade de, GÓRNIAK, Silvana Lima, GUERRA, José Luis
Format:	Journal Article
Language:	English
Published:	Faculdade de Medicina Veterinária e Zootecnia / Universidade de São Paulo 1999
Subjects:	AGRICULTURE, DAIRY & ANIMAL SCIENCE VETERINARY SCIENCES Intoxicação Crotalaria spectabilis Alcalóides de pirrolizidina Poisoning Pyrrolizidine alkaloids Milk Leite
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Summary:	Seeds of Crotalaria spectabilis, containing the pyrrolizidine alkaloid (PA) monocrotaline (MCT), were fed to a lactating dairy goat. Milk from this goat was fed to rats for 8 weeks to determine whether MCT or its toxic metabolites are transferred into the goat’s milk. Rats from the experimental group showed significantly higher (p<0.05) serum levels of ALT, AST, GGT and LDH and less weight gains (p<0.05) than control rats. The most significant lesions in rats consuming the experimental ration were mild to moderate interstitial pneumonia and a vacuolar degeneration and occasionally necrosis of periportal hepatocytes. The results of this study indicate that the PA and/or its metabolites are eliminated in milk.
ISSN:	1413-9596 1678-4456
DOI:	10.1590/S1413-95961999000200008