MICUs protect the heart by regulating mitochondrial calcium

Regulation of mitochondrial calcium uptake by the mitochondrial calcium uniporter (mtCU) complex is crucial for heart function. In a recent study, Hasan et al. demonstrated that mitochondrial calcium uptake (MICU)1 and MICU2, regulatory subunits of the complex, help maintain calcium homeostasis in c...

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Bibliographic Details
Published in:	Trends in pharmacological sciences (Regular ed.) Vol. 45; no. 11; pp. 950 - 952
Main Authors:	Ozkurede, Ulas, Pakkiriswami, Shanmugasundaram, Liu, Julia C.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-11-2024
Subjects:	calcium EMRE heart MCU MICU1 MICU2 mitochondria calcium mitochondria EMRE MICU2 MICU1 heart MCU
Online Access:	Get full text
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Summary:	Regulation of mitochondrial calcium uptake by the mitochondrial calcium uniporter (mtCU) complex is crucial for heart function. In a recent study, Hasan et al. demonstrated that mitochondrial calcium uptake (MICU)1 and MICU2, regulatory subunits of the complex, help maintain calcium homeostasis in cardiac mitochondria, providing potential targets for therapies aimed at improving mitochondrial function in heart disease. Regulation of mitochondrial calcium uptake by the mitochondrial calcium uniporter (mtCU) complex is crucial for heart function. In a recent study, Hasan et al. demonstrated that mitochondrial calcium uptake (MICU)1 and MICU2, regulatory subunits of the complex, help maintain calcium homeostasis in cardiac mitochondria, providing potential targets for therapies aimed at improving mitochondrial function in heart disease.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0165-6147 1873-3735 1873-3735
DOI:	10.1016/j.tips.2024.09.010