Topology-defined bioactive properties of porous Ti-6Al-4V scaffolds produced by laser powder bed fusion
•Porous Ti6Al4V scaffolds with varied design are additively manufactured.•Bioinspired TPMS and a strut models forming porous structures are considered.•Bioactive properties of scaffolds are studied in vitro using multipotent MMSCs.•TPMS models are superior to a strut model by osteoinductive activity...
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| Published in: | Materials letters Vol. 377; p. 137528 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier B.V
15-12-2024
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| Abstract | •Porous Ti6Al4V scaffolds with varied design are additively manufactured.•Bioinspired TPMS and a strut models forming porous structures are considered.•Bioactive properties of scaffolds are studied in vitro using multipotent MMSCs.•TPMS models are superior to a strut model by osteoinductive activity.•Sheet Gyroid and Diamond models are promising for developing 3D-printed scaffolds.
The effect of the design of additively printed Ti porous structures on their bioactive properties is elucidated by in vitro testing. 3D-printed scaffolds with pores defined by several bioinspired triply periodic minimal surfaces as well as by a strut model have been engineered. Cell proliferation, angiogenesis and osteogenesis have been studied with the help of multipotent mesenchymal stromal cells. The elementary unit size and pore design can notably modify bioactive properties of porous structures. The models providing maximal bioactive activity of developed scaffolds are discussed. |
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| AbstractList | •Porous Ti6Al4V scaffolds with varied design are additively manufactured.•Bioinspired TPMS and a strut models forming porous structures are considered.•Bioactive properties of scaffolds are studied in vitro using multipotent MMSCs.•TPMS models are superior to a strut model by osteoinductive activity.•Sheet Gyroid and Diamond models are promising for developing 3D-printed scaffolds.
The effect of the design of additively printed Ti porous structures on their bioactive properties is elucidated by in vitro testing. 3D-printed scaffolds with pores defined by several bioinspired triply periodic minimal surfaces as well as by a strut model have been engineered. Cell proliferation, angiogenesis and osteogenesis have been studied with the help of multipotent mesenchymal stromal cells. The elementary unit size and pore design can notably modify bioactive properties of porous structures. The models providing maximal bioactive activity of developed scaffolds are discussed. |
| ArticleNumber | 137528 |
| Author | Abramova, Marina M. Novruzov, Keryam M. Kapustin, Alexei V. Anisimova, Natalia Yu Ryzhkin, Alexander A. Enikeev, Nariman A. Kiselevskiy, Mikhail V. |
| Author_xml | – sequence: 1 givenname: Mikhail V. surname: Kiselevskiy fullname: Kiselevskiy, Mikhail V. organization: N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, 115478 Moscow, Russia – sequence: 2 givenname: Natalia Yu surname: Anisimova fullname: Anisimova, Natalia Yu organization: N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, 115478 Moscow, Russia – sequence: 3 givenname: Keryam M. surname: Novruzov fullname: Novruzov, Keryam M. organization: N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, 115478 Moscow, Russia – sequence: 4 givenname: Alexei V. orcidid: 0009-0006-8094-0036 surname: Kapustin fullname: Kapustin, Alexei V. organization: Laboratory for Metals and Alloys under Extreme Impacts, Ufa University of Science and Technology, 450076 Ufa, Russia – sequence: 5 givenname: Alexander A. orcidid: 0009-0002-6003-4184 surname: Ryzhkin fullname: Ryzhkin, Alexander A. organization: Laboratory for Metals and Alloys under Extreme Impacts, Ufa University of Science and Technology, 450076 Ufa, Russia – sequence: 6 givenname: Marina M. orcidid: 0000-0003-2691-6335 surname: Abramova fullname: Abramova, Marina M. organization: Laboratory for Metals and Alloys under Extreme Impacts, Ufa University of Science and Technology, 450076 Ufa, Russia – sequence: 7 givenname: Nariman A. orcidid: 0000-0002-7503-8949 surname: Enikeev fullname: Enikeev, Nariman A. email: nariman.enikeev@gmail.com organization: Laboratory for Metals and Alloys under Extreme Impacts, Ufa University of Science and Technology, 450076 Ufa, Russia |
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| SubjectTerms | Additive manufacturing Bioactive properties Porous scaffolds Ti alloys Triply periodic minimized surfaces |
| Title | Topology-defined bioactive properties of porous Ti-6Al-4V scaffolds produced by laser powder bed fusion |
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