A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance Via Blocking Receptor Auto-Induction and BIM/Bmf Expression in ALL

▪ Despite improvements in chemotherapy that have increased the 5-year survival rates of pediatric ALL to close to 90%, 15-20% of patients may relapse with a very poor prognosis. Pediatric ALL patients, particularly those in relapse can harbor a specific point mutation (E1099K) in NSD2 (nuclear recep...

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Bibliographic Details

Published in:	Blood Vol. 134; no. Supplement_1; p. 3758
Main Authors:	Li, Jianping, Troche, Catalina, Zhang, Julia Hlavka, Shrimp, Jonathan, Roth, Jacob S., Jing, Duohui, Swaroop, Alok, Kulis, Marta, Oyer, Jon, Will, Christine, Dupere-Richer, Daphne, Riva, Alberto, Pipe, Crissandra, Sobn, Amin, Norton, Sharon, Bennett, Richard Lynn, Shen, Min, Hall, Matthew D., Lock, Richard B., Licht, Jonathan D.
Format:	Journal Article
Language:	English
Published:	Elsevier Inc 13-11-2019
Online Access:	Get full text
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