Interaction study of moxifloxacin with Cu(II) ion using square-wave voltammetry and its application in the determination in tablets

• Published in: Eclética química Vol. 31; no. 1; pp. 31 - 38
• Main Authors: Trindade, Magno Aparecido Gonçalves, Cunha, Patrícia Alessandra da Cruz, De Araujo, Tatiane Alfonso, Da Silva, Glaucia Maria, Ferreira, Valdir Souza
• Format: Journal Article
• Language: English
• Published: Universidade Estadual Paulista 01-09-2018
• ISSN: 1678-4618; 1678-4618
• DOI: 10.26850/1678-4618eqj.v31.1.2006.p31-38

This work presents an electroanalytical method for the determination of moxifloxacin(MOXI) in tablets by its interaction with Cu(II) ion and subsequent electrochemical reduction at hang-ing mercury drop electrode (HMDE). A well-defined reduction peak at -0.21 V vs. Ag/AgCl inPhosphate buffer 0.04 mol L -1 pH 8.0 was observed for the complex reduction MOXI-Cu(II), usingsquare-wave voltammetry (SWV). Using a 10 s of accumulation time at -0.40 V was found a limitdetection of 3.60x10 -8 mol l -1 . The obtained results have shown good agreement with those obtained byspectrophotometric method.