Contribution of Adipokine Gene Expression in Mesenteric Adipose Tissue to the Pathogenesis of Insulin Resistance in Obese Patients
Mesenteric adipose tissue, being a component of visceral adipose tissue, has a high lipolytic activity. Excessive accumulation of visceral adipose tissue increases the risk of metabolic disorders leading to severe consequences. Therefore, the aim of the presented study was to estimate the production...
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| Published in: | Human physiology Vol. 44; no. 4; pp. 474 - 480 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
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| Abstract | Mesenteric adipose tissue, being a component of visceral adipose tissue, has a high lipolytic activity. Excessive accumulation of visceral adipose tissue increases the risk of metabolic disorders leading to severe consequences. Therefore, the aim of the presented study was to estimate the production of adipokine and proinflammatory molecules by the adipose tissue of small intestine mesentery evaluating its contribution to the formation of insulin resistance in obesity. The role of the activity of
LEP
,
SERPINA
12,
RARRES
2, and
TNF
α genes encoding leptin, vaspin, chemerin, and
TNF
α in adipose tissue of small intestinal mesentery in patients with abdominal obesity with a different state of carbohydrate metabolism was studied. The changes in serum/plasma content of the examined mediators that we detected are closely associated with their production in the adipose tissue of small intestinal mesentery. The revealed interrelations between the production of mediators (adipokines, proinflammatory molecules) studied with the parameters of carbohydrate metabolism indicate an important role of mesenteric adipose tissue in the formation of insulin resistance in obesity. |
|---|---|
| AbstractList | Mesenteric adipose tissue, being a component of visceral adipose tissue, has a high lipolytic activity. Excessive accumulation of visceral adipose tissue increases the risk of metabolic disorders leading to severe consequences. Therefore, the aim of the presented study was to estimate the production of adipokine and proinflammatory molecules by the adipose tissue of small intestine mesentery evaluating its contribution to the formation of insulin resistance in obesity. The role of the activity of
LEP
,
SERPINA
12,
RARRES
2, and
TNF
α genes encoding leptin, vaspin, chemerin, and
TNF
α in adipose tissue of small intestinal mesentery in patients with abdominal obesity with a different state of carbohydrate metabolism was studied. The changes in serum/plasma content of the examined mediators that we detected are closely associated with their production in the adipose tissue of small intestinal mesentery. The revealed interrelations between the production of mediators (adipokines, proinflammatory molecules) studied with the parameters of carbohydrate metabolism indicate an important role of mesenteric adipose tissue in the formation of insulin resistance in obesity. Mesenteric adipose tissue, being a component of visceral adipose tissue, has a high lipolytic activity. Excessive accumulation of visceral adipose tissue increases the risk of metabolic disorders leading to severe consequences. Therefore, the aim of the presented study was to estimate the production of adipokine and proinflammatory molecules by the adipose tissue of small intestine mesentery evaluating its contribution to the formation of insulin resistance in obesity. The role of the activity of LEP, SERPINA12, RARRES2, and TNFα genes encoding leptin, vaspin, chemerin, and TNFα in adipose tissue of small intestinal mesentery in patients with abdominal obesity with a different state of carbohydrate metabolism was studied. The changes in serum/plasma content of the examined mediators that we detected are closely associated with their production in the adipose tissue of small intestinal mesentery. The revealed interrelations between the production of mediators (adipokines, proinflammatory molecules) studied with the parameters of carbohydrate metabolism indicate an important role of mesenteric adipose tissue in the formation of insulin resistance in obesity. |
| Author | Skuratovskaia, D. A. Kirienkova, E. V. Zatolokin, P. A. Mironyuk, N. I. Vulf (Vasilenko), M. A. Litvinova, L. S. |
| Author_xml | – sequence: 1 givenname: M. A. surname: Vulf (Vasilenko) fullname: Vulf (Vasilenko), M. A. email: mary-jean@yandex.ru organization: Baltic Federal University – sequence: 2 givenname: D. A. surname: Skuratovskaia fullname: Skuratovskaia, D. A. organization: Baltic Federal University – sequence: 3 givenname: E. V. surname: Kirienkova fullname: Kirienkova, E. V. organization: Baltic Federal University – sequence: 4 givenname: P. A. surname: Zatolokin fullname: Zatolokin, P. A. organization: Baltic Federal University, Regional Clinical Hospital of the Kaliningrad region – sequence: 5 givenname: N. I. surname: Mironyuk fullname: Mironyuk, N. I. organization: Regional Clinical Hospital of the Kaliningrad region – sequence: 6 givenname: L. S. surname: Litvinova fullname: Litvinova, L. S. organization: Baltic Federal University |
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| Cites_doi | 10.1016/S1471-4914(02)02396-1 10.1016/S2468-1253(16)30026-7 10.1016/j.bbadis.2013.05.017 10.1111/jcmm.12282 10.3389/fendo.2016.00030 10.4239/wjd.v5.i5.606 10.1038/s41598-017-01517-6 10.1042/CS20160005 10.1038/nri2921 10.1016/j.nut.2011.09.009 10.2337/db09-0277 10.1371/journal.pone.0134613 10.1007/s00125-012-2644-8 10.1016/j.cmet.2013.05.010 10.4049/jimmunol.1001269 10.1053/j.gastro.2008.01.070 10.1016/j.cmet.2013.05.008 10.1155/2015/823481 10.1155/2012/379024 10.1155/2017/4875026 |
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| Keywords | mesenteric adipose tissue enzyme immunoassay type 2 diabetes mellitus (DM) adipokines PCR obesity |
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| References | Choe, Huh, Hwang (CR3) 2016; 7 Blüher (CR11) 2016; 130 Ouchi, Parker, Lugus, Walsh (CR4) 2011; 11 Borer (CR18) 2014; 5 Lee (CR13) 2014; 1842 Dalamaga, Chou, Shields (CR17) 2013; 18 Camp, Ren, Leff (CR19) 2002; 8 He, Sun, Zeng (CR2) 2017; 7 Magnusson, Liblau, Boehmer (CR7) 2008; 134 Drouet, Dubuquoy, Desreumaux, Bertin (CR6) 2012; 28 Zúñiga, Shen, Joyce-Shaikh (CR21) 2010; 185 Yang, Li, Tian, Wang (CR23) 2017 Glantz (CR9) 1997 Badoud, Lam, Perreault (CR10) 2015; 10 Karrasch, Schaeffler (CR1) 2016; 29 Mathis (CR15) 2013; 17 Copps, White (CR16) 2012; 55 Hirabara, Gorjão, Vinolo (CR12) 2012 Sell, Laurencikiene, Taube (CR22) 2009; 58 Fülöp, Seres, Lorincz (CR20) 2014; 18 Coffey, O’Leary (CR5) 2016; 1 Jung, Choi (CR14) 2014; 15 Vandesompele, De Preter, Pattyn (CR8) 2002; 18 Dimova, Tankova (CR24) 2015 T. Karrasch (7119_CR1) 2016; 29 U.J. Jung (7119_CR14) 2014; 15 B.C. Lee (7119_CR13) 2014; 1842 M. Dalamaga (7119_CR17) 2013; 18 H. Sell (7119_CR22) 2009; 58 H. He (7119_CR2) 2017; 7 K.D. Copps (7119_CR16) 2012; 55 P. Fülöp (7119_CR20) 2014; 18 W. Yang (7119_CR23) 2017 F.C. Magnusson (7119_CR7) 2008; 134 S.M. Hirabara (7119_CR12) 2012 K.T. Borer (7119_CR18) 2014; 5 S.A. Glantz (7119_CR9) 1997 F. Badoud (7119_CR10) 2015; 10 N. Ouchi (7119_CR4) 2011; 11 S.S. Choe (7119_CR3) 2016; 7 J.C. Coffey (7119_CR5) 2016; 1 M. Blüher (7119_CR11) 2016; 130 H.S. Camp (7119_CR19) 2002; 8 R. Dimova (7119_CR24) 2015 D. Mathis (7119_CR15) 2013; 17 M. Drouet (7119_CR6) 2012; 28 J. Vandesompele (7119_CR8) 2002; 18 L.A. Zúñiga (7119_CR21) 2010; 185 |
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He – volume: 130 start-page: 1603 issue: 18 year: 2016 ident: 7119_CR11 publication-title: Clin. Sci. doi: 10.1042/CS20160005 contributor: fullname: M. Blüher – volume: 28 start-page: 113 issue: 2 year: 2012 ident: 7119_CR6 publication-title: Nutrition doi: 10.1016/j.nut.2011.09.009 contributor: fullname: M. Drouet – volume-title: BioMed Res. Int. year: 2015 ident: 7119_CR24 doi: 10.1155/2015/823481 contributor: fullname: R. Dimova – volume: 18 start-page: 1313 issue: 7 year: 2014 ident: 7119_CR20 publication-title: J. Cell. Mol. Med. doi: 10.1111/jcmm.12282 contributor: fullname: P. Fülöp – volume: 15 start-page: 6184 issue: 4 year: 2014 ident: 7119_CR14 publication-title: inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease, Int. J. Mol. Sci. contributor: fullname: U.J. Jung – volume: 17 start-page: 851 issue: 6 year: 2013 ident: 7119_CR15 publication-title: Cell Metab. doi: 10.1016/j.cmet.2013.05.008 contributor: fullname: D. 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Yang – volume: 55 start-page: 2565 issue: 10 year: 2012 ident: 7119_CR16 publication-title: Diabetologia doi: 10.1007/s00125-012-2644-8 contributor: fullname: K.D. Copps – volume: 18 start-page: 29 issue: 1 year: 2013 ident: 7119_CR17 publication-title: Cell Metab. doi: 10.1016/j.cmet.2013.05.010 contributor: fullname: M. Dalamaga – volume: 185 start-page: 6947 issue: 11 year: 2010 ident: 7119_CR21 publication-title: J. Immunol. doi: 10.4049/jimmunol.1001269 contributor: fullname: L.A. Zúñiga – volume: 1 start-page: 238 issue: 3 year: 2016 ident: 7119_CR5 publication-title: Lancet Gastroenterol. Hepatol. doi: 10.1016/S2468-1253(16)30026-7 contributor: fullname: J.C. Coffey |
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| SubjectTerms | Adipose tissue Biomedical and Life Sciences Biomedicine Carbohydrate metabolism Gene expression Human Physiology Inflammation Insulin Insulin resistance Leptin Life Sciences Mesentery Metabolic disorders Metabolism Obesity Small intestine Tumor necrosis factor-α |
| Title | Contribution of Adipokine Gene Expression in Mesenteric Adipose Tissue to the Pathogenesis of Insulin Resistance in Obese Patients |
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