Microviscosity of erythrocyte membranes during chronic heart failure in patients of middle and senior age groups

• Published in: Advances in gerontology Vol. 5; no. 2; pp. 89 - 93
• Main Authors: Rebrova, T. Yu, Afanasiev, S. A., Putrova, O. D., Repin, A. N.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01-04-2015; Springer Nature B.V
• Subjects: Age groups; Cardiovascular disease; Geriatrics/Gerontology; Lipids; Medicine; Medicine & Public Health; Membranes; erythrocyte membrane microviscosity; chronic ischemic heart disease; pyrene; age
• ISSN: 2079-0570; 2079-0589
• DOI: 10.1134/S2079057015020101

Microviscosity coefficients were studied in the area of integrated and annular lipids of erythrocyte membranes in the peripheral blood of patients aged 35–50 and 60–75 with chronic coronary heart disease (CHD), as well as healthy donors of corresponding age. It was found in healthy donors that the microviscosity coefficients in the area of integrated and of annular lipids are significantly higher in the senior age group (60–75 years). In CHD, both an increase and a decrease in the microviscosity parameters in the area of lipid–lipid interactions can be characteristic for erythrocyte membranes, regardless of the patient age. In the protein–lipid contacts, an increase in microviscosity parameters is characteristic for patients aged 35–50 and, in contrast, a decrease in the microviscosity coefficient was observed in 60- to 75-year-old patients. It was concluded that the indicators of erythrocyte membrane microviscosity in patients of different age groups reflect both the implementation of general mechanisms of adaptive changes in cell membranes and the individual characteristics determined by their lipid and protein composition during the development of chronic CHD.