Confocal imaging of Bim translocation to endoplasmic reticulum during DHA-induced ASTC-a-1 cell apoptosis

Confocal imaging of Bim translocation to endoplasmic reticulum during DHA-induced ASTC-a-1 cell apoptosis

Bim, a proapoptotic member of Bcl-2 family, plays an important role in cell apoptosis. It is generally thought that Bim translocates to mitochondria in response to apoptotic stimuli. We use confocal microscopy to image the temporal-spatial dynamics of Bim during dihydroartemisinin （DHA） induced huma...

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Bibliographic Details
Published in:Chinese optics letters no. 10; pp. 950 - 952
Main Author: 陈敏 卢盈颖 陈同生 屈军乐
Format: Journal Article
Language:English
Published: 10-10-2010
Subjects:
DHA
共焦成像
共聚焦显微镜
内质网
双氢青蒿素
细胞凋亡
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Summary:Bim, a proapoptotic member of Bcl-2 family, plays an important role in cell apoptosis. It is generally thought that Bim translocates to mitochondria in response to apoptotic stimuli. We use confocal microscopy to image the temporal-spatial dynamics of Bim during dihydroartemisinin （DHA） induced human lung adenocarcinoma （ASTC-a-1） cell apoptosis. Interestingly, we find that DHA induces Bim translocation to endoplasmic reticulum （ER） rather than mitochondria, implying that Bim-ER pathway might be involved in the DHA-induced ASTC-a-1 cell apoptosis.
Bibliography:Q255
31-1890/O3
TS225.24
ISSN:1671-7694
DOI:10.3788/COL20100810.0950