Nucleosomes play a dual role in regulating transcription dynamics

Transcription has a mechanical component, as the translocation of the transcription machinery or RNA polymerase (RNAP) on DNA or chromatin is dynamically coupled to the chromatin torsion. This posits chromatin mechanics as a possible regulator of eukaryotic transcription, however, the modes and mech...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 121; no. 28; p. e2319772121
Main Authors:	Brahmachari, Sumitabha, Tripathi, Shubham, Onuchic, José N, Levine, Herbert
Format:	Journal Article
Language:	English
Published:	United States 09-07-2024
Subjects:	Chromatin - genetics Chromatin - metabolism DNA - chemistry DNA - genetics DNA - metabolism DNA, Superhelical - chemistry DNA, Superhelical - genetics DNA, Superhelical - metabolism DNA-Directed RNA Polymerases - genetics DNA-Directed RNA Polymerases - metabolism Nucleosomes - genetics Nucleosomes - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Transcription, Genetic transcription nucleosomes supercoiling
Online Access:	Get full text
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