DIPG-48. DIPG THROUGH THE LOOKING GLASS

• Published in: Neuro-oncology (Charlottesville, Va.) Vol. 25; no. Supplement_1; p. i24
• Main Author: Senga, Sasi S
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 12-06-2023
• Subjects: Final Category: Diffuse Intrinsic Pontine Glioma/Diffuse Midline Gliomas - DPIG
• DOI: 10.1093/neuonc/noad073.095
• EISSN: 1523-5866
• ISSN: 1522-8517

Diffuse intrinsic pontine glioma (DIPG) has a peculiar pathogenesis with canonical Histone variants H3.1/H3.2 wherein Lysine 27 (H3K27) is substituted to methionine (H3K27M). It is restricted to pons and affects young children whereas non canonical H3.3 mutations result in tumours across the midline and affects older children. This discrepancy in the spatiotemporal distribution provides cues to target DIPG. Based on altered neuronal signalling which is a hallmark of cancer, a deeper understanding of neuron tumour interaction may unravel numerous new targets. One such target is light. The restriction of specific spectrum of light may hinder the progression and even the development of tumours in young children. It provides a lucrative therapeutic option which can be implemented merely by blocking a certain spectrum of light with glasses in an otherwise baffling disease. It warrants a deeper understanding of the light exposure on DIPG tumour progression.