IgE Antibody Binding Sites On Mite Group I Allergens Defined By X-ray Crystallography And Site-directed Mutagenesis

Site-directed mutagenesis analysis of residues from epitopes identified by X-ray crystallography allows the location of amino acids important for allergen-antibody interaction and reveals mechanisms of protein interaction and the basis of allergenic cross-reactivity.

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 127; no. 2; p. AB265
Main Authors:	Pomés, A, Glesner, J, Vailes, L.D, Minor, W, Chruszcz, M, Chapman, M.D
Format:	Journal Article
Language:	English
Published:	St. Louis Mosby, Inc 01-02-2011 Elsevier Limited
Subjects:	Allergies Allergy and Immunology Binding sites Mutagenesis Mutation
Online Access:	Get full text
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Description
Summary:	Site-directed mutagenesis analysis of residues from epitopes identified by X-ray crystallography allows the location of amino acids important for allergen-antibody interaction and reveals mechanisms of protein interaction and the basis of allergenic cross-reactivity.
ISSN:	0091-6749 1097-6825
DOI:	10.1016/j.jaci.2010.12.1055