Diimidazo[1,2-c :4', 5'-e]pyrimidines : N6-N1 conformationally restricted adenosines

Tethering the N6-substituents of N6-substituted adenosines to N1 has resulted in a series of conformationally restricted adenosine analogues. The resultant diimidazo[1,2-c:4',5'-e]pyrimidines were shown to be adenosine A1 selective.

Saved in:

Bibliographic Details
Published in:	Bioorganic & medicinal chemistry letters Vol. 8; no. 6; pp. 695 - 698
Main Authors:	CAMP, D, YING LI, MCCLUSKEY, A, MONI, R. W, QUINN, R. J
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier 17-03-1998
Subjects:	Animals Biological and medical sciences Brain - metabolism Cells, Cultured Corpus Striatum - metabolism Humans Medical sciences Models, Chemical Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Phenylisopropyladenosine - analogs & derivatives Phenylisopropyladenosine - metabolism Purinergic P1 Receptor Agonists Pyrimidines - chemical synthesis Pyrimidines - metabolism Rats Receptors, Purinergic P1 - metabolism Rat Angular nitrogen heterocycle Ligand Rodentia Central nervous system A1 Adenosine receptor Steric hindrance Selectivity Tricyclic compound In vitro Vertebrata Biological fixation Mammalia Structure activity relation Animal Affinity Benzenic compound Ribonucleoside Chemical synthesis Brain (vertebrata)
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Tethering the N6-substituents of N6-substituted adenosines to N1 has resulted in a series of conformationally restricted adenosine analogues. The resultant diimidazo[1,2-c:4',5'-e]pyrimidines were shown to be adenosine A1 selective.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(98)00101-2