American Cockroach Allergen rPer a 3 Expressed in Pichia pastoris

American Cockroach Allergen rPer a 3 Expressed in Pichia pastoris

Per a 3, an American cockroach (Periplaneta americana) allergen shows homology to hemocyanin superfamily proteins and is reported to show skin test reactivity in ~80% of cockroach allergic patients. Since neither the natural or recombinant allergen is available, we expressed rPer a 3 in Pichia pasto...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology Vol. 125; no. 2; p. AB146
Main Authors: Glesner, J, Arruda, L.K, Chapman, M.D, Pomés, A
Format: Journal Article
Language:English
Published: St. Louis Mosby, Inc 01-02-2010
Elsevier Limited
Subjects:
Allergy and Immunology
Fungi
Online Access:Get full text
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Summary:Per a 3, an American cockroach (Periplaneta americana) allergen shows homology to hemocyanin superfamily proteins and is reported to show skin test reactivity in ~80% of cockroach allergic patients. Since neither the natural or recombinant allergen is available, we expressed rPer a 3 in Pichia pastoris for allergenicity studies.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2009.12.574