Synthesis and Characterization of Dimeric Thio-Schiff Bases by Nano Cerium Oxide and Examination of Their Antimicrobial Activities

• Published in: Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol. 25; no. 2; pp. 364 - 378
• Main Authors: DALMAZ, Aslıhan, DURMUŞ, Sefa, DULGER, Gorkem, DÜLGER, Başaran
• Format: Journal Article
• Language: English
• Published: Sakarya Üniversitesi 15-04-2021
• Subjects: Mühendislik; Türkiye; Sakarya; Anti-bacterial; Anti-candidal; Disulphide-Schiff bases; Nano-catalyst; Ceria
• ISSN: 2147-835X; 1301-1043; 2147-835X
• DOI: 10.16984/saufenbilder.737671

In this work, firstly, CeO2 nanoparticles, which can be used as catalysts in many reactions, were synthesized by preparing aqueous solution of cerium(III) nitrate hexahydrate in basic medium. In the second step, the synthesis of dimeric thio Schiff bases was carried out using two different methods. Effect of catalyst on some parameters such as reaction time and yield of product were investigated. The antimicrobial activities of the ligands have been screened in vitro against the organisms Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae (Gram negative bacteria), Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Bacillus cereus (Gram positive bacteria) and Candida albicans, C. tropicalis, C. guilliermondii, C. glabrata by Disc Diffusion and Microdilution methods. At the same time, antimicrobial activities of ligands were compared to standard antibiotics (Cefotaxime, Amoxicillin/clavulanic acid, Posacanazole, Nystatin and Gentamicin). Generally, the results obtained in this research showed that all tested ligands exhibited more effect towards Gram positive bacteria and Candida species as compared to standard antibiotics.