Synthesis, fluorescence, enzymes effects, and evaluation of tetrahydroxy substituted zinc phthalocyanine as multitarget metabolic enzyme inhibitors with molecular docking: the biochemistry-oriented drug design

• Published in: Journal of the Iranian Chemical Society Vol. 21; no. 9; pp. 2413 - 2424
• Main Authors: Solğun, Derya Güngördü, Sadeghian, Nastaran, Taskin-Tok, Tugba, Ağirtaş, Mehmet Salih, Taslimi, Parham
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-09-2024
• Subjects: Analytical Chemistry; Biochemistry; Chemistry; Chemistry and Materials Science; Inorganic Chemistry; Organic Chemistry; Original Paper; Physical Chemistry; Fluorescence; Enzyme inhibition; Phthalocyanine; Synthesis; Molecular docking
• ISSN: 1735-207X; 1735-2428
• DOI: 10.1007/s13738-024-03079-7

Synthesis and properties of tetrahydroxy substituted zinc phthalocyanine is reported. UV–Visible spectrum for the aggregation properties of the compound and fluorescence properties were examined by excitation, emission spectra. This complex was an inhibitor of butyrylcholinesterase (BChE),
α
-Gly,
α
-Amy, and acetylcholinesterase (AChE) enzymes for tetra- hydroxy phthalocyaninato zinc (II) 3 with IC50 values of 49.18 μM for
α
-Amy, 110.85 μM for BChE, 35.13 μM for
α
-glycosidase and 54.63 μM for AChE, respectively. On the otherside, within the scope of computational study, in vitro activity behavior and states of the related complex, which cannot be explained experimentally, were evaluated at atomic level. The pharmacodynamics properties of the complex (3) were elucidated by molecular docking against four target enzymes, AChE, BChE,
α
-Gly and
α
-Amy. After that, its potential drug candidate was investigated based on its pharmacokinetic properties with help of in silico-ADMET analysis. As a result of all the applications, a desired goal in medicinal chemistry was to develop new, reliable and safe cholinesterase and
α
-glycosidase inhibitors with high efficacy.