αEβ7 Expression Increases With the Extent of Cutaneous Involvement in Mycosis Fungoides
Cell adhesion molecules are essential to lymphocyte migration in neoplastic and inflammatory skin diseases. Our aim was to investigate possible differences in cell adhesion molecule expression between mycosis fungoides (MF) and inflammatory skin diseases (drug reactions and allergic contact dermatit...
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| Published in: | The American journal of dermatopathology Vol. 41; no. 9; pp. 630 - 636 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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01-09-2019
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| Abstract | Cell adhesion molecules are essential to lymphocyte migration in neoplastic and inflammatory skin diseases. Our aim was to investigate possible differences in cell adhesion molecule expression between mycosis fungoides (MF) and inflammatory skin diseases (drug reactions and allergic contact dermatitis).
We selected 33 biopsies from patients with MF and 10 biopsies of patients with inflammatory skin diseases from Department of Pathology-Universidade Federal de São Paulo (UNIFESP) from January 1997 to December 2013. Expression of α4β1 integrin and αEβ7 integrin was assessed by immunohistochemistry in intraepidermal lymphocytes by counting 4 microscopic epidermal fields (×400) and comparing those between the 2 groups.
We observed increased expression of integrin αEβ7 in intraepidermal lymphocytes in advanced stages of MF (T3 and T4). αEβ7 expression was detected in intraepidermal dendritic cells of MF and inflammatory diseases samples. The expression of E-cadherin in epidermal cells in MF outlined Pautrier microabscesses, whereas in inflammatory diseases, spongiosis reduced its expression in keratinocytes.
The findings presented here support the idea that the lymphocyte migratory mechanism observed in neoplasms is similar to that of inflammatory processes of the skin. |
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| AbstractList | Background:
Cell adhesion molecules are essential to lymphocyte migration in neoplastic and inflammatory skin diseases. Our aim was to investigate possible differences in cell adhesion molecule expression between mycosis fungoides (MF) and inflammatory skin diseases (drug reactions and allergic contact dermatitis).
Methods:
We selected 33 biopsies from patients with MF and 10 biopsies of patients with inflammatory skin diseases from Department of Pathology—Universidade Federal de São Paulo (UNIFESP) from January 1997 to December 2013. Expression of α4β1 integrin and αEβ7 integrin was assessed by immunohistochemistry in intraepidermal lymphocytes by counting 4 microscopic epidermal fields (×400) and comparing those between the 2 groups.
Results:
We observed increased expression of integrin αEβ7 in intraepidermal lymphocytes in advanced stages of MF (T3 and T4). αEβ7 expression was detected in intraepidermal dendritic cells of MF and inflammatory diseases samples. The expression of E-cadherin in epidermal cells in MF outlined Pautrier microabscesses, whereas in inflammatory diseases, spongiosis reduced its expression in keratinocytes.
Conclusions:
The findings presented here support the idea that the lymphocyte migratory mechanism observed in neoplasms is similar to that of inflammatory processes of the skin. Cell adhesion molecules are essential to lymphocyte migration in neoplastic and inflammatory skin diseases. Our aim was to investigate possible differences in cell adhesion molecule expression between mycosis fungoides (MF) and inflammatory skin diseases (drug reactions and allergic contact dermatitis). We selected 33 biopsies from patients with MF and 10 biopsies of patients with inflammatory skin diseases from Department of Pathology-Universidade Federal de São Paulo (UNIFESP) from January 1997 to December 2013. Expression of α4β1 integrin and αEβ7 integrin was assessed by immunohistochemistry in intraepidermal lymphocytes by counting 4 microscopic epidermal fields (×400) and comparing those between the 2 groups. We observed increased expression of integrin αEβ7 in intraepidermal lymphocytes in advanced stages of MF (T3 and T4). αEβ7 expression was detected in intraepidermal dendritic cells of MF and inflammatory diseases samples. The expression of E-cadherin in epidermal cells in MF outlined Pautrier microabscesses, whereas in inflammatory diseases, spongiosis reduced its expression in keratinocytes. The findings presented here support the idea that the lymphocyte migratory mechanism observed in neoplasms is similar to that of inflammatory processes of the skin. BACKGROUNDCell adhesion molecules are essential to lymphocyte migration in neoplastic and inflammatory skin diseases. Our aim was to investigate possible differences in cell adhesion molecule expression between mycosis fungoides (MF) and inflammatory skin diseases (drug reactions and allergic contact dermatitis). METHODSWe selected 33 biopsies from patients with MF and 10 biopsies of patients with inflammatory skin diseases from Department of Pathology-Universidade Federal de São Paulo (UNIFESP) from January 1997 to December 2013. Expression of α4β1 integrin and αEβ7 integrin was assessed by immunohistochemistry in intraepidermal lymphocytes by counting 4 microscopic epidermal fields (×400) and comparing those between the 2 groups. RESULTSWe observed increased expression of integrin αEβ7 in intraepidermal lymphocytes in advanced stages of MF (T3 and T4). αEβ7 expression was detected in intraepidermal dendritic cells of MF and inflammatory diseases samples. The expression of E-cadherin in epidermal cells in MF outlined Pautrier microabscesses, whereas in inflammatory diseases, spongiosis reduced its expression in keratinocytes. CONCLUSIONSThe findings presented here support the idea that the lymphocyte migratory mechanism observed in neoplasms is similar to that of inflammatory processes of the skin. |
| Author | Teixeira, Solange Pistori Silva, Maria Regina Regis Batista, Mariana Dias Landman, Gilles Tomimori, Jane Barata, Mariangela Crispino |
| Author_xml | – sequence: 1 givenname: Mariangela Crispino surname: Barata fullname: Barata, Mariangela Crispino organization: Department of Pathology, Escola Paulista de Medicina, UNIFESP, São Paulo, Brazil – sequence: 2 givenname: Solange Pistori surname: Teixeira fullname: Teixeira, Solange Pistori organization: Department of Dermatology, Escola Paulista de Medicina, UNIFESP, São Paulo, Brazil – sequence: 3 givenname: Mariana Dias surname: Batista fullname: Batista, Mariana Dias organization: Department of Dermatology, Escola Paulista de Medicina, UNIFESP, São Paulo, Brazil – sequence: 4 givenname: Jane surname: Tomimori fullname: Tomimori, Jane organization: Department of Dermatology, Escola Paulista de Medicina, UNIFESP, São Paulo, Brazil – sequence: 5 givenname: Gilles surname: Landman fullname: Landman, Gilles organization: Department of Pathology, Escola Paulista de Medicina, UNIFESP, São Paulo, Brazil – sequence: 6 givenname: Maria Regina Regis surname: Silva fullname: Silva, Maria Regina Regis organization: Department of Pathology, Escola Paulista de Medicina, UNIFESP, São Paulo, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30839339$$D View this record in MEDLINE/PubMed |
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| Snippet | Cell adhesion molecules are essential to lymphocyte migration in neoplastic and inflammatory skin diseases. Our aim was to investigate possible differences in... Background: Cell adhesion molecules are essential to lymphocyte migration in neoplastic and inflammatory skin diseases. Our aim was to investigate possible... BACKGROUNDCell adhesion molecules are essential to lymphocyte migration in neoplastic and inflammatory skin diseases. Our aim was to investigate possible... |
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| SubjectTerms | Aged Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Biopsy, Needle Brazil Cell Adhesion Molecules - analysis Cross-Sectional Studies Dermatitis - genetics Dermatitis - pathology Disease Progression Female Hospitals, University Humans Immunohistochemistry Integrins - metabolism Male Middle Aged Mycosis Fungoides - genetics Mycosis Fungoides - pathology Prognosis Retrospective Studies Risk Assessment Severity of Illness Index Skin Neoplasms - genetics Skin Neoplasms - pathology |
| Title | αEβ7 Expression Increases With the Extent of Cutaneous Involvement in Mycosis Fungoides |
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